Transmission of OXA-23-Producing Carbapenem-Resistant Acinetobacter Baumannii Through Lung Transplantation – 2018
- During 2018, CDC was notified of a rare case of organ-donor derived transmission of a multidrug-resistant bacteria (OXA-23-producing carbapenem-resistant Acinetobacter baumannii) during lung transplantation. As part of the Organ Procurement and Transplantation Network ad hoc Disease Transmission Advisory Committee, CDC conducted an investigation. This case illustrates the potential for multidrug-resistant organisms to move between healthcare facilities though transplantation, facilitating their spread across regions.
- CDC’s Antibiotic Resistance Laboratory Network (AR Lab Network), a tiered laboratory network established in 2016 to support nationwide capacity to rapidly detect antibiotic resistance, tested isolates from the organ donor and recipient using advanced diagnostics to confirm the donor-derived transmission.
- This case highlights the importance of regional collaborations of public health authorities to respond to emerging resistance and prevent the spread of multidrug-resistant organisms. Donor culture results identifying multidrug-resistant organisms should be promptly shared with the Organ Procurement and Transplantation Network so recipient healthcare centers can be notified in order to inform treatment of clinical infections and enable implementation of infection control measures to prevent further spread within the recipients’ healthcare facilities.
“The spread of multidrug-resistant organisms is a public health threat and our investigation highlights how organ transplantation can introduce multidrug-resistant organisms into different healthcare facilities and regions. A systematic public health response to multidrug-resistant organisms, supported by the AR Lab Network, provides an important framework to facilitate outbreak investigations and communication between healthcare facilities and health departments.”
– Ana Bardossy, MD, EIS Class of 2018
CDC Media Relations
Ana Bardossy, MD,
EIS Class of 2018
CDC National Center for Emerging and Zoonotic Infectious Diseases Division of Healthcare Quality Promotion
Education: MD: Universidad Nacional de Cordoba, 2005
Work Experience: Clinical Study Coordinator, Henry
Ford Health System, Detroit, Michigan, 2014-Present;
Staff Infectious Disease Physician and Infection Control
Program Coordinator, Instituto Modelo de
Cardiologia Privado SRL, 2012-2014;
Infectious Disease physician, Hospital Rawson, 2009-2014;
Staff Infectious Disease Physician and Infection Control Program
Coordinator, Hospital Italiano, 2008-2012