Worldwide, there are at least 580,000 cases of drug-resistant tuberculosis (TB). We must address TB both at home and abroad to ensure a safer, healthier America. To protect Americans from threats like drug-resistant TB, CDC is reinforcing international collaborations and capacities for antibiotic resistance prevention, surveillance, and infection control with countries worldwide. This work includes improving TB infection control (prompt detection and separation of infected patients, airborne precautions, and personal protective equipment for healthcare personnel) in key healthcare facilities. CDC is also strengthening diagnostic and treatment services for TB in the public and private sector, and increasing TB treatment adherence to reduce rates and spread.