Important update: Healthcare facilities
CDC has updated select ways to operate healthcare systems effectively in response to COVID-19 vaccination. Learn more
UPDATE
Given new evidence on the B.1.617.2 (Delta) variant, CDC has updated the guidance for fully vaccinated people. CDC recommends universal indoor masking for all teachers, staff, students, and visitors to K-12 schools, regardless of vaccination status. Children should return to full-time in-person learning in the fall with layered prevention strategies in place.
UPDATE
The White House announced that vaccines will be required for international travelers coming into the United States, with an effective date of November 8, 2021. For purposes of entry into the United States, vaccines accepted will include FDA approved or authorized and WHO Emergency Use Listing vaccines. More information is available here.
UPDATE
Travel requirements to enter the United States are changing, starting November 8, 2021. More information is available here.

Different COVID-19 Vaccines

Different COVID-19 Vaccines
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Approved or Authorized Vaccines

Three COVID-19 vaccines are authorized or approved for use in the United States to prevent COVID-19. Pfizer-BioNTech or Moderna (COVID-19 mRNA vaccines) are preferred.  You may get Johnson & Johnson’s Janssen COVID-19 vaccine in some situations.

Pfizer-BioNTech
Moderna
Johnson & Johnson’s Janssen

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Vaccine Brand Name [ 1 ]
Pfizer-BioNTech

Ages Recommended
5+ years old

Primary Series
2 doses
Given 3 weeks (21 days) apart [ 3 ]

Booster Dose
Everyone ages 18 years and older should get a booster dose of either Pfizer-BioNTech or Moderna (COVID-19 vaccines) 5 months after the last dose in their primary series.
Teens 12-17 years old should get a Pfizer-BioNTech COVID-19 Vaccine booster 5 months after the last dose in their primary series.

When Fully Vaccinated4
2 weeks after 2nd dose

Vaccine Brand Name [ 1 ]
Moderna

Ages Recommended
18+ years old

Primary Series
2 doses
Given 4 weeks (28 days) apart [ 3 ]

Booster Dose
Everyone ages 18 years and older should get a booster dose of either Pfizer-BioNTech or Moderna (COVID-19 vaccines) 5 months after the last dose in their primary series.

When Fully Vaccinated4
2 weeks after 2nd dose

Vaccine Brand Name [ 1,2 ]
Johnson & Johnson’s Janssen

Ages Recommended
18+ years

Primary Series
1 dose

Booster Dose
Everyone ages 18 years and older should get a booster dose of either Pfizer-BioNTech or Moderna (mRNA COVID-19 vaccines) at least 2 months after the first dose of J&J/Janssen COVID-19 vaccine. You may get J&J/Janssen in some situations.

When Fully Vaccinated4
2 weeks after 1st dose

Pfizer-BioNTech [ 1 ]

Moderna [ 1 ]

Johnson & Johnson’s Janssen [ 1,2 ]

Pfizer-BioNTech [ 1 ]

Ages Recommended
5+ years old

Moderna [ 1 ]

Ages Recommended
18+ years old

Johnson & Johnson’s Janssen [ 1,2 ]

Ages Recommended
18+ years

Pfizer-BioNTech [ 1 ]

Primary Series
2 doses
Given 3 weeks (21 days) apart [ 3 ]

Moderna [ 1 ]

Primary Series
2 doses
Given 4 weeks (28 days) apart [ 3 ]

Johnson & Johnson’s Janssen [ 1,2 ]

Primary Series
1 dose

Pfizer-BioNTech [ 1 ]

Booster Dose
Everyone ages 18 years and older should get a booster dose of either Pfizer-BioNTech or Moderna (COVID-19 vaccines) 5 months after the last dose in their primary series.

Teens 12-17 years old should get a Pfizer-BioNTech COVID-19 Vaccine booster 5 months after the last dose in their primary series.

Moderna [ 1 ]

Booster Dose
Everyone ages 18 years and older should get a booster dose of either Pfizer-BioNTech or Moderna (COVID-19 vaccines) 5 months after the last dose in their primary series.

Johnson & Johnson’s Janssen [ 1,2 ]

Booster Dose
Everyone ages 18 years and older should get a booster dose of either Pfizer-BioNTech or Moderna (mRNA COVID-19 vaccines) at least 2 months after the first dose of J&J/Janssen COVID-19 vaccine.  You may get J&J/Janssen in some situations.

Pfizer-BioNTech [ 1 ]

When Fully Vaccinated4
2 weeks after 2nd dose

Moderna [ 1 ]

When Fully Vaccinated4
2 weeks after 2nd dose

Johnson & Johnson’s Janssen [ 1,2 ]

When Fully Vaccinated4
2 weeks after 1st dose

1 If you had a severe allergic reaction after a previous dose or if you have a known (diagnosed) allergy to a COVID-19 vaccine ingredient, you should not get that vaccine. If you have been instructed not to get one type of COVID-19 vaccine, you may still be able to get another type.

2 CDC has updated its recommendations for COVID-19 vaccines with a preference for mRNA (Pfizer-BioNTech or Moderna) vaccines. Learn more about the updated guidance on the use of Janssen (Johnson & Johnson) COVID-19 vaccine.

3 You should get your second shot as close to the recommended 3-week or 4-week interval as possible. You should not get the second dose early.

4As with vaccines for other diseases, people who are up to date on their COVID-19 vaccines are optimally protected. Learn more about staying up to date on your COVID-19 vaccines.

Vaccine Types and How They Work

    • Understanding How COVID-19 Vaccines Work
      Learn how the body fights infection and how COVID-19 vaccines protect people by producing immunity. Also see the different types of COVID-19 vaccines that currently are available or are undergoing large-scale (Phase 3) clinical trials in the United States.​
    • COVID-19 mRNA Vaccines (Pfizer-BioNTech and Moderna)
      Information about mRNA vaccines generally and COVID-19 vaccines that use this technology.
    • Viral Vector COVID-19 Vaccines (J&J/Janssen)
      Information about viral vector vaccines generally and COVID-19 vaccines that use this technology.
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For Healthcare and Public Health

COVID-19 Clinical and Professional Resources