Groups at Higher Risk for BRCA Gene Mutations
Some people have a higher risk for a BRCA gene mutation than others. Certain family history patterns indicate a higher risk for a BRCA1 or BRCA2 gene mutation.
You may be at increased risk for a BRCA1 or BRCA2 mutation if your family history includes—
- Several relatives with breast cancer.
- Any relatives with ovarian cancer.
- Relatives who got breast cancer before age 50.
- A relative with cancer in both breasts.
- A relative who had both breast and ovarian cancers.
- A male relative with breast cancer.
- Ashkenazi Jewish ancestry (Central or Eastern European) and any relative with breast or ovarian cancer.
- A relative with a known BRCA gene mutation.
You may have a higher risk for a mutation if you have had—
- Breast cancer before age 50.
- Triple-negative breast cancer.
- Male breast cancer.
- Breast cancer more than once.
- Ovarian cancer, fallopian tube cancer, or primary peritoneal (lining of the abdomen) cancer at any age.
- Both breast and ovarian cancers.
- Breast cancer or ovarian cancer at any age, and you are of Ashkenazi Jewish ancestry (Central or Eastern European).
- Breast cancer and you have a family member with breast or ovarian cancer.