Symptoms, Diagnosis, & Treatment


  • Initial symptoms can include fever, headache, nausea, vomiting, fatigue, and sometimes rash.
  • Cache Valley virus can cause severe disease, including infection of the brain (encephalitis) or the membranes around the brain and spinal cord (meningitis).
  • Symptoms of severe disease (meningitis or encephalitis) include stiff neck, confusion, loss of coordination, difficulty speaking, or seizures.
  • Some patients with Cache Valley virus infection can die.


  • See your healthcare provider if you develop the symptoms described above.
  • Your healthcare provider can order tests to look for Cache Valley virus infection or other infections that cause similar symptoms.
  • More information on diagnostic testing is available on the “For Healthcare Providers” page.


  • There is no medicine to treat Cache Valley virus infection.
  • Treat the symptoms:
    • Get plenty of rest.
    • Drink fluids to prevent dehydration.
  • Take over-the-counter pain relievers to reduce fever, headaches, or other discomfort.
  • Patients with severe disease may need to be hospitalized for breathing support, staying hydrated, and to reduce swelling of the brain.