Overall, in the United States, OA affects 13.9% of adults aged 25 years and older and 33.6% (12.4 million) of those 65+ in 2005; an estimated 26.9 million US adults in 2005 up from 21 million in 1990 (believed to be conservative estimate).2
Average annual prevalence of OA in the ambulatory health care system in the United States, from 2001–2005, was estimated to be 3.5% which amounts to 7.7 million with OA.3
OA accounts for 47.4% of all arthritis-related hospitalizations; 3,161,100 hospitalizations for OA as principal diagnosis in 2011.18
Knee and hip joint replacement procedures (usually for OA) accounted for 35% of total arthritis-related procedures during hospitalization.19
Nationally, from 1992 to 2011 the rate (per 100,000) of total knee replacement increased 217% from 203.6 to 645.1. In addition, the rate (per 100,000) of total hip replacement increased 119% from 139.9 to 306.6.18
Non-Hispanic Blacks and persons with low income have lower rates of total knee replacement but higher complications and mortality than Non-Hispanic whites.20,21
Lawrence RC, Felson DT, Helmick CG, et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II. Arthritis Rheum. 2008;58(1):26-35.
Sacks JJ, Luo Y-H, Helmick CG. Prevalence of specific types of arthritis and other rheumatic conditions in the ambulatory health care system in the
United States, 2001–2005. Arthritis Care & Research. 2010;62 (4):460-464.
Dillon CF, Rasch EK, Gu Q, Hirsch R. Prevalence of knee osteoarthritis in the United States: arthritis data from the Third National Health and Nutrition Examination Survey 1991–1994. J Rheumatol, 2006;33(11):2271-2279.
Leyland KM, Hart DJ, Javaid MK, Judge A, et al. The natural history of radiographic knee osteoarthritis: a fourteen-year population-based cohort study. Arthritis Rheum 2012;64(7):2243-51.
Felson DT, Naimark A, Anderson J, Kazis L, Castelli W, Meenan RF. The prevalence of knee osteoarthritis in the elderly. The Framingham Osteoarthritis Study. Arthritis Rheum. 1987;30(8):914-918.
Jordan JM, Helmick CG, Renner JB, et al. Prevalence of knee symptoms and radiographic and symptomatic knee osteoarthritis in African Americans and Caucasians: The Johnston County Osteoarthritis Project. J Rheumatol. 2007;34(1):172-180.
Jordan JM, Helmick CG, Renner JB, et al. Prevalence of hip symptoms and radiographic and symptomatic hip osteoarthritis in African Americans and Caucasians: the Johnston County Osteoarthritis Project. J Rheumatol 2009;36(4):809-15.
Zhang Y, Niu J, Kelly-Hayes M, et al. Prevalence of symptomatic hand osteoarthritis and its impact on functional status among elderly: the Framingham Study. Am J Epidemiol.2002;156:1021-7.
Dillon CF, Hirsch R, Rasch EK, Gu Q. Symptomatic hand osteoarthritis in the United States: prevalence and functional impairment estimates from the third U.S. National Health and Nutrition Examination Survey, 1991–1994. Am J Phys Med Rehabil, 2007;86(1):12-21.
Oliveria SA, Felson DT, Reed JI, et al. Incidence of symptomatic hand, hip, and knee osteoarthritis among patients in a health maintenance organization. Arthritis Rheum. 1995;38(8):1134-1141.
Felson DT, Zhang Y, Hannan MT, et al. The incidence and natural history of knee osteoarthritis in the elderly. The Framingham Osteoarthritis Study. Arthritis Rheum. 1995;38(10):1500-1505.
Cooper C, Snow S, McAlindon TE, et al .Risk factors for the incidence and progression of radiographic knee osteoarthritis. Arthritis Rheum. 2000;43(5):995-1000.
Buckwalter JA, Saltzman C, Brown T. The impact of osteoarthritis. Clin OrthopedRel Res. 2004:427S: S6-S15.
Srikanth VK, Fryer JL, Zhai G, Winzenberg TM, Hosmer D, Jones G. A meta-analysis of sex difference prevalence, incidence and severity of osteoarthritis. Osteoarthritis Cartilage. 2005;13:769-781.
Nüesch E, Dieppe P, Reichenbach S, et al. All cause and disease specific mortality in patients with knee or hip osteoarthritis: population based cohort study. BMJ. 2011;342:d1165.
Sacks JJ, Helmick CG, Langmaid G. Deaths from arthritis and other rheumatic conditions, United States, 1979–1998. J Rheumatol. 2004;31:1823-1828.
Gabriel SE, Crowson CS, Campion ME, et al. Direct medical costs unique to people with arthritis. J Rheumatol. 1997;24(4):719–725.
Mahomed NN, Barrett J, Katz JN Baron JA, Wright J, Losina E. Epidemiology of total knee replacements in the United States Medicare population. J Bone Joint Surg Am. 2005;87(6):1222-1228.
CDC. Racial disparities in total knee replacement among Medicare enrollees--United States, 2000–2006. MMWR. 2009;58(6):133-8.
Hagglund KJ, Clark MJ, Hilton SA, Hewett JE. Access to healthcare services among persons with osteoarthritis and rheumatoid arthritis. Am J Phys Med Rehabil. 2005;84(9):702-711.
Murphy L, Helmick CG.The impact of osteoarthritis in the United States: a population-health perspective. Am J Nurs. 2012;112(3 Suppl 1):S13-9.
Maetzel A, Li LC, Pencharz J, Tomlinson F Bombardier C. The economic burden associated with osteoarthritis, rheumatoid arthritis, and hypertension: a comparative study. Ann Rheum Dis. 2004;63(4):395-401.
Guccione AA, Felson DT, Anderson JJ, et al. The effects of specific medical conditions on the functional limitations of elders in the Framingham Study. Am J Pub Health. 1994;84(3):351-358.
Michaud CM, McKenna MT, Begg S, et al. The burden of disease and injury in the United States 1996. Popul Health Metr. 2006;4:11. http://www.pophealthmetrics.com/content/4/1/11. Accessed July, 19, 2007.
Felson DT, Zhang Y. An update on the epidemiology of knee and hip osteoarthritis with a view to prevention. Arthritis Rheum. 1998;41(8):1343-1355.