Common Respiratory Infections: Do you need antibiotics [for] common cold, chest cold, flu, and COVID-19? Antibiotics DO NOT WORK against viruses that cause the common cold, most chest colds, flu, and COVID-19. Ask your healthcare professional about the best way to feel better while your body fights off the virus. For more information, visit www.cdc.gov/antibiotic-use or call 1-800-CDC-INFO.