A roadmap to ALS prevention: strategies and priorities

Affiliates Michael Benatar [1], Stephen A Goutman [2], Kim A Staats [3], Eva L Feldman [2], Marc Weisskopf [4], Evelyn Talbott [5], Kuldip D Dave [6], Neil M Thakur [6], Ammar Al-Chalabi [7]


[1] Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA
[2] Neurology, University of Michigan, Ann Arbor, Michigan, USA
[3] Staats Life Sciences Consulting, Los Angeles, California, USA
[4] Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA
[5] Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, USA
[6] ALS Association, Washington, District of Columbia, USA
[7] Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King’s College London, London, UK

Journal Journal of Neurology, Neurosurgery and Psychiatry
Summary This paper lays out a prescriptive roadmap for ASL prevention research. The paper identifies a select number of potential high-risk groups to be prioritized in such research. These groups include: People with genetic risk factors, people with mild motor impairment, relatives of people with ALS or other neurological diseases, people who have already developed frontotemporal dementia, veterans, and people with exposures to environmental risks. The paper additionally identifies a list of priorities to facilitate ALS prevention research.
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