Case-control study in ALS using the National ALS Registry: lead and agricultural chemicals are potential risk factors
Affiliates | Hiroshi Mitsumoto [1] , Diana C. Garofalo [2], Madison Gilmore [1] , Leslie Andrews [3], Regina M. Santella [4] , Howard Andrews [5] , Martin McElhiney [6] , Jennifer Murphy [7], Jeri W. Nieves [2], Judith Rabkin [6], Jonathan Hupf [1], D. Kevin Horton [8], Paul Mehta [8], and Pam Factor-Litvak [2]
[1] Department of Neurology, Columbia University Irving Medical Center |
Journal | Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration |
Summary | This study examines the relationship between occupational exposure to lead and pesticides as potential causes of amyotrophic lateral sclerosis (ALS). Increased risk of ALS diagnosis was reported among those with occupational exposure to lead and agricultural chemicals. Moreover, increased measures of oxidative stress thought to be resulting from these exposures was more frequently reported amongst cases compared to controls. |
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Page last reviewed: November 18, 2021
Content source: Agency for Toxic Substances and Disease Registry