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ABCs Report: Streptococcus pneumoniae, 2016

This webpage is archived for historical purposes and is no longer being maintained or updated.

April 4, 2018: Content on this page kept for historical reasons.

Active Bacterial Core Surveillance (ABCs): Emerging Infections Program Network

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Surveillance Note

Missing race (n=284) data were multiply imputed using sequential regression imputation methods.

ABCs Areas

California (San Francisco County and children < 18 years, adults ≥ 65 years in Alameda and Contra Costa counties); Colorado (5 county Denver area); Connecticut;  Georgia (20 county Atlanta area); Maryland (6 county Baltimore area); Minnesota; New Mexico; New York (15 county Rochester and Albany areas and children <5 years in Erie county); Oregon (3 county Portland area); Tennessee (20 counties).

ABCs Population

The surveillance areas represent 32,182,579 persons.

Source: National Center for Health Statistics bridged‑race vintage 2016 postcensal file

ABCs Case Definition

Invasive pneumococcal disease: isolation of Streptococcus pneumoniae from normally sterile site in resident of a surveillance area in 2016.

ABCs Methodology

ABCs personnel routinely contacted all microbiology laboratories serving acute care hospitals in their area to identify cases. Standardized case report forms that include information on demographic characteristics, clinical syndrome, and outcome of illness were completed for each identified case. WGS based characterization was conducted on all pneumococcal isolates, which includes deduction of capsular serotype and MIC predictions (including PBP typing system for determining beta lactam antibiotic MICs). Conventional MIC testing is conducted on selected strains.. Regular laboratory audits assessed completeness of active surveillance and detected additional cases.

Rates of  invasive pneumococcal disease were calculated using population estimates for 2016 from the bridged-race vintage 2016 postcensal file. For national estimates, race‑ and age‑specific rates of disease were applied from the aggregate surveillance area to the age and racial distribution of the 2016 U.S. population.  Cases with missing data, excluding ethnicity, were multiply imputed using sequential regression imputation methods.

Reported ABCs Profiles

Race No. (Rate*)
White 2,097 (8.7)
Black 751 (13.9)
Other 209 (7.9)

* Per 100,000 population for ABCs areas

Age (years) Cases
No. (Rate*)
Deaths
No. (Rate*)
< 1 57 (13.6) 2 (0.48)
1 56 (13.3) 1 (0.24)
2-4 67 (5.3) 5 (0.40)
5-17 78 (1.4) 2 (0.04)
18-34 190 (2.6) 14 (0.19)
35-49 427 (7.0) 40 (0.65)
50-64 1014 (16.4) 131 (2.12)
65-74 574 (20.1) 74 (2.60)
75-84 355 (26.4) 44 (3.28)
≥ 85 239 (37.9) 54 (8.56)
Total 3,057 (9.5) 367 (1.14)

* Per 100,000 population for ABCs areas

Syndrome No. (%*)
Meningitis 192 (6.3)
Bacteremia without focus 577 (18.9)
Pneumonia with bacteremia 1,997 (65.3)

* Percent of cases

Antibiotic S* I R
Susceptibility
Penicillin+ 96.0 1.8 2.2
Cefotaxime 97.5 2.0 0.4
Erythromycin 69.3 0.0 30.7
TMP/Sulfa 81.7 12.3 6.0
Tetracycline 87.8 0.0 12.2
Levofloxacin 99.8 0.0 0.2
Vancomycin 100  0.0  0.0

Based on reference lab testing of 2,720 isolates.
* Susceptible; Intermediate; Resistant based on year 2014 CLSI definitions
+ Penicillin CLSI breakpoints changed in 2009

National Estimates of Invasive Disease

Cases: 30,400 (9.4/100,000)
Deaths: 3,690 (1.14/100,000)

Healthy People 2020 Update

Objective: Decrease the incidence of invasive pneumococcal infections to 12 per 100,000 persons less than 5 years of age and to 31 per 100,000 persons aged 65 and older.

Age (year) 2020 Objective 2016 Rate*
< 5 12/100,000 8/100,000
≥ 65 31/100,000 24/100,000

* Per 100,000 U.S. population < 5 years or ≥ 65 years

Citation

Centers for Disease Control and Prevention. 2016. Active Bacterial Core Surveillance Report, Emerging Infections Program Network, Streptococcus pneumoniae, 2016.

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