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ABCs Report: Streptococcus pneumoniae, 2015

This webpage is archived for historical purposes and is no longer being maintained or updated.

March 8, 2016: Content on this page kept for historical reasons.

Active Bacterial Core Surveillance (ABCs): Emerging Infections Program Network

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Surveillance Note

Missing race (n=304) data were multiply imputed using sequential regression imputation methods.

ABCs Areas

California (San Francisco County and children < 18 years in Alameda and Contra Costa counties); Colorado (5 county Denver area); Connecticut; Georgia (20 county Atlanta area); Maryland (6 county Baltimore area); Minnesota; New Mexico; New York (15 county Rochester and Albany areas and children <5 years in Erie county); Oregon (3 county Portland area); Tennessee (20 counties).

ABCs Population

The surveillance areas represent 31,977,800 persons.

Source: National Center for Health Statistics bridged-race vintage 2015 postcensal file

ABCs Case Definition

Invasive pneumococcal disease: isolation of Streptococcus pneumoniae from normally sterile site in resident of a surveillance area in 2015.

ABCs Methodology

ABCs personnel routinely contacted all microbiology laboratories serving acute care hospitals in their area to identify cases. Standardized case report forms that include information on demographic characteristics, clinical syndrome, and outcome of illness were completed for each identified case. Pneumococcal isolates were collected and sent to reference laboratories for susceptibility testing  using CLSI methods and serotyping. Regular laboratory audits assessed completeness of active surveillance and detected additional cases.

Rates of  invasive pneumococcal disease were calculated using population estimates for 2015 from the bridged-race vintage 2015 postcensal file. For national estimates, race  and age specific rates of disease were applied from the aggregate surveillance area to the age and racial distribution of the 2015 U.S. population.  Cases with missing data, excluding ethnicity, were multiply imputed using sequential regression imputation methods.

Reported ABCs Profiles

Reported ABCs Profile
Race No. (Rate*)
White 2, 089 (8.7)
Black 683 (12.8)
Other 171 (6.6)

* Per 100,000 population for ABCs areas

Reported ABCs Profile
Age (years) Cases
No. (Rate*)
Deaths
No. (Rate*)
< 1 77 (18.4) 1 (0.24)
1 54 (12.9) 1 (0.24)
2-4 65 (5.1) 2 (0.16)
5-17 70 (1.3) 0 (0.00)
18-34 179 (2.5) 6 (0.08)
35-49 416 (6.7) 31 (0.50)
50-64 924 (15.0) 94 (1.53)
65-74 497 (18.2) 63 (2.30)
75-84 379 (29.0) 59 (4.50)
≥ 85 282 (45.3) 72 (11.56)
Total 2,943 (9.2) 329 (1.03)

* Per 100,000 population for ABCs areas

Per 100,000 population for ABCs areas by syndrome and number
Syndrome No. (%*)
Meningitis 208 (7.1)
Bacteremia without focus 500 (17.0)
Pneumonia with bacteremia 2,003 (68.1)

* Percent of cases

Percent of cases
Antibiotic S* I R
Susceptibility % % %
Penicillin+ 95.6 2.0 2.3
Cefotaxime 97.5 2.0 0.5
Erythromycin 69.6 0.2 30.2
TMP/Sulfa 81.3 11.0 7.7
Tetracycline 88.8 0.2 11.0
Levofloxacin 99.6 0.0 0.1
Vancomycin 100

Based on reference lab testing of 2,597 isolates.
* Susceptible; Intermediate; Resistant based on year 2014 CLSI definitions
+ Penicillin CLSI breakpoints changed in 2009

National Estimates of Invasive Disease

Cases: 29,500 (9.2/100,000)
Deaths: 3,350 (1.04/100,000)

Healthy People 2020 Update

Objective: Decrease the incidence of invasive pneumococcal infections to 12 per 100,000 persons less than 5 years of age and to 31 per 100,000 persons aged 65 and older.

Healthy People 2020 Update by age 2015 and 2020
Age (year) 2020 Objective 2015 Rate*
< 5 12/100,000 9/100,000
≥ 65 31/100,000 25/100,000

* Per 100,000 U.S. population < 5 years or ≥ 65 years

Citation

Centers for Disease Control and Prevention. 2015. Active Bacterial Core Surveillance Report, Emerging Infections Program Network, Streptococcus pneumoniae, 2015.

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