ABCs Report: Streptococcus pneumoniae, 2014

May 20, 2016: Content on this page kept for historical reasons.

Active Bacterial Core Surveillance (ABCs): Emerging Infections Program Network

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Surveillance Note

Missing race (n=304) data were multiply imputed using sequential regression imputation methods.

ABCs Areas

California (San Francisco County and children < 18 years in Alameda and Contra Costa counties); Colorado (5 county Denver area); Connecticut; Georgia (20 county Atlanta area); Maryland (6 county Baltimore area); Minnesota; New Mexico; New York (15 county Rochester and Albany areas and children <5 years in Erie county); Oregon (3 county Portland area); Tennessee (20 counties).

ABCs Population

The surveillance areas represent 31,328,211 persons.

Source: National Center for Health Statistics bridged-race vintage 2014 postcensal file

ABCs Case Definition

Invasive pneumococcal disease: isolation of Streptococcus pneumoniae from normally sterile site in resident of a surveillance area in 2014.

ABCs Methodology

ABCs personnel routinely contacted all microbiology laboratories serving acute care hospitals in their area to identify cases. Standardized case report forms that include information on demographic characteristics, clinical syndrome, and outcome of illness were completed for each identified case. Pneumococcal isolates were collected and sent to reference laboratories for susceptibility testing using CLSI methods and serotyping. Regular laboratory audits assessed completeness of active surveillance and detected additional cases.

Rates of invasive pneumococcal disease were calculated using population estimates for 2014 from the bridged-race vintage 2014 postcensal file. For national estimates, race-and age-specific rates of disease were applied from the aggregate surveillance area to the age and racial distribution of the 2014 U.S. population. Cases with missing data, excluding ethnicity, were multiply imputed using sequential regression imputation methods.

Reported ABCs Profiles

Reported ABCs Profiles
Race No. (Rate*)
White 1,977 (8.3)
Black 647 (12.5)
Other 192 (8.0)

* Per 100,000 population for ABCs areas

Reported ABCs Profiles by age, cases, rate, and deaths
Age (years) Cases
No. (Rate*)
Deaths
No. (Rate*)
< 1 66 (15.9) 2 (0.48)
1 43 (10.3) 0 (0.00)
2-4 80 (6.3) 1 (0.08)
5-17 77 (1.4) 3 (0.05)
18-34 193 (2.7) 13 (0.18)
35-49 407 (6.6) 43 (0.70)
50-64 919 (15.1) 100 (1.64)
65-74 458 (19.1) 58 (2.41)
75-84 334 (28.2) 41 (3.46)
≥ 85 239 (42.6) 45 (8.01)
Total 2,816 (9.0) 306 (0.98)

* Per 100,000 population for ABCs areas

Reported ABCs Profiles by syndrome, number, and %
Syndrome No. (%*)
Meningitis 186 (6.6)
Bacteremia without focus 451 (16.0)
Pneumonia with bacteremia 1,983 (70.4)

* Percent of cases

Reported ABCs Profiles by antibiotic
Antibiotic S* I R
Susceptibility % % %
Penicillin 94.8 3.1 2.1
Cefotaxime 96.6 2.8 0.6
Erythromycin 68.3 0.4 31.3
TMP/Sulfa 80.7 9.6 9.8
Tetracycline 88.4 0 11.6
Levofloxacin 99.6 0 0.3
Vancomycin 100 0 0

Based on reference lab testing of 2,485 isolates.
* Susceptible; Intermediate; Resistant based on year 2014 CLSI definitions

National Estimates of Invasive Disease

Cases: 29,100 (9.1/100,000)
Deaths: 3,250 (1.0/100,000)

Healthy People 2020 Update

Objective: Decrease the incidence of invasive pneumococcal infections to 12 per 100,000 persons less than 5 years of age and to 31 per 100,000 persons aged 65 and older.

Reported ABCs Profiles by age, objective, and rate
Age (year) 2020 Objective 2013 Rate*
< 5 12/100,000 8.7/100,000
≥ 65 31/100,000 24.8/100,000

* Per 100,000 U.S. population < 5 years or ≥ 65 years

Citation

Centers for Disease Control and Prevention. 2014. Active Bacterial Core Surveillance Report, Emerging Infections Program Network, Streptococcus pneumoniae, 2014.

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Page last reviewed: May 20, 2016 (archived document)