ABCs Report: Streptococcus pneumoniae, 2012

January 28, 2014: Content on this page kept for historical reasons.

Active Bacterial Core Surveillance (ABCs): Emerging Infections Program Network

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Surveillance Note

Missing race (n=327) data were multiply imputed using sequential regression imputation methods.

ABCs Areas

California (San Francisco County and children < 5 years in Alameda and Contra Costa counties); Colorado (5 county Denver area); Connecticut; Georgia (20 county Atlanta area); Maryland (6 county Baltimore area); Minnesota; New Mexico; New York (15 county Rochester and Albany areas and children <5 years in Erie county); Oregon (3 county Portland area); Tennessee (20 counties)

ABCs Population

The surveillance areas represent 30,356,544 persons.

Source: National Center for Health Statistics bridged‑race vintage 2012 postcensal file

ABCs Case Definition

Invasive pneumococcal disease: isolation of Streptococcus pneumoniae from normally sterile site in resident of a surveillance area in 2012.

ABCs Methodology

ABCs personnel routinely contacted all microbiology laboratories serving acute care hospitals in their area to identify cases. Standardized case report forms that include information on demographic characteristics, clinical syndrome, and outcome of illness were completed for each identified case. Pneumococcal isolates were collected and sent to reference laboratories for susceptibility testing using CLSI methods and serotyping. Regular laboratory audits assessed completeness of active surveillance and detected additional cases.

Rates of invasive pneumococcal disease were calculated using population estimates for 2012. For national estimates, race‑ and age‑specific rates of disease were applied from the aggregate surveillance area to the age and racial distribution of the 2012 U.S. population. Cases with missing data, excluding ethnicity, were multiply imputed using the sequential regression imputation method.

Reported ABCs Profiles

Reported ABCs Profiles
Race No. (Rate*)
White 2,217 (9.53)
Black 668 (13.5)
Other 154 (7.2)

* Cases per 100,000 population for ABCs areas

Reported ABCs Profiles by age
Age (years) Cases
No. (Rate*)
Deaths
No. (Rate*)
< 1 65 (15.7) 1 (0.24)
1 57 (13.6) 1 (0.24)
2‑4 75 (5.9) 0 (0.00)
5‑17 95 (1.9) 7 (0.14)
18-34 201 (2.8) 7 (0.10)
35-49 468 (7.5) 37 (0.60)
50‑64 942 (15.9) 91 (1.53)
≥ 65 1,136 (29.6) 163 (4.24)
Total 3,039 (10.0) 307 (1.01)

* Cases or deaths per 100,000 population for ABCs areas

Reported ABCs Profiles by syndrome
Syndrome No. (%*)
Meningitis 214 (7.1)
Bacteremia without focus 511 (16.8)
Pneumonia with bacteremia 2,101 (69.1)

* Percent of cases

Reported ABCs Profiles by antibiotic
Antibiotic S* I R
Susceptibility % % %
Penicillin 94.1 3.1 2.8
Cefotaxime 95.6 3.5 0.9
Erythromycin 70.6 0.5 28.9
TMP/Sulfa 80.4 9.3 10.3
Tetracycline 88.7 0.3 11.0
Levofloxacin 99.6 0.0 0.4
Vancomycin 100.0 0.0 0.0

Based on reference lab testing of 2,753 isolates
* Susceptible; Intermediate; Resistant based on year 2012 CLSI definitions

National Estimates of Invasive Disease

Cases: 31,600 (10.1/100,000)
Deaths: 3,300 (1.1/100,000)

Healthy People 2020 Update

Objective: Decrease the incidence of invasive pneumococcal infections to 12 per 100,000 persons less than 5 years of age and to 31 per 100,000 persons aged 65 and older.

Reported ABCs Profiles by objective
Age (year) 2020 Objective 2012 Rate*
< 5 12/100,000 9/100,000
≥ 65 31/100,000 30/100,000

* Cases per 100,000 U.S. population < 5 years or ≥ 65 years

Citation

Centers for Disease Control and Prevention. 2013. Active Bacterial Core Surveillance Report, Emerging Infections Program Network, Streptococcus pneumoniae, 2012.

 

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