ABCs Report: Haemophilus influenzae, 2018

June 7, 2020: Content on this page kept for historical reasons.

Active Bacterial Core Surveillance (ABCs): Emerging Infections Program Network

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Surveillance Note

Missing race (n=71) data were multiply imputed using sequential regression imputation methods.

ABCs Areas

California (3 county San Francisco Bay area); Colorado (5 county Denver area); Connecticut; Georgia; Maryland; Minnesota; New Mexico; New York (15 county Rochester and Albany areas); Oregon; Tennessee (20 urban counties)

ABCs Population

The surveillance areas represent 44,817,242 persons.

Source: National Center for Health Statistics bridged‑race vintage 2018 postcensal file

ABCs Case Definition

Invasive Haemophilus influenzae (Hi) disease:  isolation of Hi from normally sterile site in a resident of a surveillance area in 2018.

ABCs Methodology

ABCs personnel routinely contacted all microbiology laboratories serving acute care hospitals in their area to identify cases. Standardized case report forms that include information on demographic characteristics, clinical syndrome, and outcome of illness were completed for each identified case.  Serotyping was done on Hi isolates at CDC and state laboratories. Regular laboratory audits assessed completeness of active surveillance and detected additional cases.

All rates of invasive Hi disease were calculated using population estimates for 2018 from the bridged-race vintage 2018 postcensal file. For national estimates, race‑ and age‑specific rates of disease were applied from the aggregate surveillance areas to the race‑ and age‑specific distribution of the 2018 U.S. population.  Cases with missing data, excluding ethnicity, were multiply imputed using sequential regression imputation methods.

Reported ABCs Profiles

Reported ABCs Profiles table 1
Race No. (Rate*)
White 197 (2.4)
Black 680 (2.1)
Other 56 (1.4)
Total 933 (2.1)

* Per 100,000 population for ABCs areas

 

Reported ABCs Profiles table 2
Syndrome Cases
No. (%*)
Deaths
No. (Rate)
Meningitis 66 (7.1) 1 (1.6)
Bacteremia without focus 234 (25.1) 26 (12)
Pneumonia with bacteremia 495 (53.1) 62 (12.6)

* Percent of cases
Deaths per 100 cases with known outcome

Reported ABCs Profiles table 3
Age (years) Serotype b
No. (Rate*)
Serotype Non‑b
No. (Rate*)
Serotype Non‑Type
No. (Rate*)
Serotype Unknown
No. (Rate*)
< 1 2 (0.39) 17 (3.29) 27 (5.23) 6 (1.16)
  1 0 (0.00) 8 (1.51) 8 (1.52) 0 (0.00)
2‑4 0 (0.00) 9 (0.55) 8 (0.49) 2 (0.12)
5‑17 0 (0.00) 8 (0.11) 14 (0.19) 1 (0.01)
18‑34 0 (0.00) 10 (0.10) 57 (0.54) 10 (0.10)
35‑49 2 (0.02) 15 (0.17) 58 (0.66) 8 (0.09)
50‑64 3 (0.03) 57 (0.65) 127 (1.45) 15 (0.17)
65-74 2 (0.05) 43 (1.05) 109 (2.66) 17 (0.41)
75-84 1 (0.05) 26 (1.32) 123 (6.23) 10 (0.51)
≥85 1 (0.12) 14 (1.66) 101 (12.01) 14 (1.66)
Total 11 (0.02) 207 (0.46) 632 (1.41) 83 (0.19)

* Per 100,000 population for ABCs areas
Non-typeable isolates

National Estimates of Invasive Disease

Cases: 6,840 (2.09/100,000)
Deaths: 810 (0.25/100,000)

Healthy People 2020 Update
Invasive Haemophilus influenzae type b disease

Objective: Decrease the incidence of invasive Haemophilus influenzae type B disease to 0.27 cases per 100,000 persons less than 5 years of age

Reported ABCs Profiles table 4
Age (year) 2020 Objective 2017 Rate*
< 5 0.27/100,000 0.08/100,000

* Per 100,000 U.S. population < 5 years

Citation

Centers for Disease Control and Prevention. 2018. Active Bacterial Core Surveillance Report, Emerging Infections Program Network, Haemophilus influenza 2018.

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