Latent TB Infection Resource Hub

This statement from the Advisory Council for the Elimination of Tuberculosis updates the strategy to eliminate TB in the United States. The report provides new recommendations to prevent TB, specifically through focus on identifying individuals at risk and testing and treating latent TB infection.

The U.S. Preventive Services Task Force (USPSTF) makes recommendations about the effectiveness of specific preventive care services for patients without obvious related signs or symptoms.

These updated 2020 latent TB infection treatment guidelines include the NTCA- and CDC-recommended treatment regimens that comprise three preferred rifamycin-based regimens and two alternative monotherapy regimens with daily isoniazid.

Latent Tuberculosis Infection Treatment Regimens

Latent Tuberculosis Infection Treatment Regimens

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CDC continues to recommend 3HP for treatment of latent TB infection in adults and now recommends use of 3HP 1) in persons with latent TB infection aged 2–17 years; 2) in persons with latent TB infection who have HIV infection, including acquired immunodeficiency syndrome (AIDS), and are taking antiretroviral medications with acceptable drug-drug interactions with rifapentine; and 3) by DOT or self-administered therapy (SAT) in persons aged ≥2 years.

These guidelines are intended for clinicians, other health care providers, patients with HIV, and policy makers in the United States.

Information and tools for patients receiving treatment for latent TB infection. Many resources are available in multiple languages.

4R Regimen Medication Tracker

Patients can use this tracker to help them complete the 4R regimen for latent TB infection.

3HP Regimen Medication Tracker

Patients can use this tracker to help complete the 12-dose regimen for latent TB infection.

3HR Regimen Medication Tracker

Patients can use this tracker to help them complete the 3HR regimen for latent TB infection.