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Volume 30, Number 4—April 2024
Research

A One Health Perspective on Salmonella enterica Serovar Infantis, an Emerging Human Multidrug-Resistant Pathogen

Jennifer Mattock1Comments to Author , Marie Anne Chattaway, Hassan Hartman, Timothy J. Dallman2, Anthony M. Smith, Karen Keddy, Liljana Petrovska3, Emma J. Manners4, Sanelisiwe T. Duze, Shannon Smouse, Nomsa Tau, Ruth Timme, Dave J. Baker, Alison E. Mather, John Wain, and Gemma C. Langridge
Author affiliations: University of East Anglia, Norwich, UK (J. Mattock, E.J. Manners, A.E. Mather, J. Wain); UK Health Security Agency, London, UK (M.A. Chattaway, H. Hartman, T.J. Dallman); National Institute for Communicable Diseases, Johannesburg, South Africa (A.M. Smith, S. Smouse, N. Tau); University of Pretoria, Pretoria, South Africa (K. Keddy); Animal and Plant Health Agency, Addlestone, UK (L. Petrovska); University of the Witwatersrand, Johannesburg (S.T. Duze); US Food and Drug Administration, College Park, Maryland, USA (R. Timme); Quadram Institute Bioscience, Norwich (D.J. Baker, A.E. Mather, J. Wain, G.C. Langridge)

Main Article

Figure 2

Core single-nucleotide polymorphism maximum-likelihood phylogeny of 1,288 representatives of 5,283 isolates in One Health–focused analysis of emerging multidrug-resistant pathogen Salmonella enterica serovar Infantis. The inner ring around the phylogeny is annotated with the Bayesian hierarchical clusters found by fastbaps. Cluster A consists of 348 representatives of 1,624 isolates; cluster B consists of 831 representatives of 3,283 isolates; and cluster C consists of 109 representatives of 376 isolates. The outer rings show the percentage of isolates in each 25-SNP cluster that were from each continent and source. Isolate origin was identified for Africa (n = 316), Asia (n = 312), Europe (n = 1,641), North America (n = 2,861), and South America (n = 128); the origin of the remaining isolates was unknown (n = 25). Sources were animal feed (n = 74), environmental (n = 268), food (n = 390), human (n = 3,149), other animals (n = 321), poultry (n = 300), poultry products (n = 684), and unknown (n = 97).

Figure 2. Core single-nucleotide polymorphism maximum-likelihood phylogeny of 1,288 representatives of 5,283 isolates in One Health–focused analysis of emerging multidrug-resistant pathogen Salmonella enterica serovar Infantis. The inner ring around the phylogeny is annotated with the Bayesian hierarchical clusters found by fastbaps. Cluster A consists of 348 representatives of 1,624 isolates; cluster B consists of 831 representatives of 3,283 isolates; and cluster C consists of 109 representatives of 376 isolates. The outer rings show the percentage of isolates in each 25-SNP cluster that were from each continent and source. Isolate origin was identified for Africa (n = 316), Asia (n = 312), Europe (n = 1,641), North America (n = 2,861), and South America (n = 128); the origin of the remaining isolates was unknown (n = 25). Sources were animal feed (n = 74), environmental (n = 268), food (n = 390), human (n = 3,149), other animals (n = 321), poultry (n = 300), poultry products (n = 684), and unknown (n = 97).

Main Article

1Current affiliation: University of Edinburgh, Edinburgh, Scotland, UK.

2Current affiliation: Utrecht University, Utrecht, the Netherlands.

3Current affiliation: UK Health Security Agency, London, UK.

4Current affiliation: European Bioinformatics Institute, Cambridge, UK.

Page created: February 08, 2024
Page updated: March 20, 2024
Page reviewed: March 20, 2024
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