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Volume 29, Number 5—May 2023
CME ACTIVITY - Research

Emergence of Erythromycin-Resistant Invasive Group A Streptococcus, West Virginia, USA, 2020–2021

Lillie M. Powell, Soo Jeon Choi, Chloe E. Chipman, Megan E. Grund, P. Rocco LaSala1, and Slawomir Lukomski1Comments to Author 
Author affiliation: West Virginia University, Morgantown, West Virginia, USA

Main Article

Table 1

Phenotypic antimicrobial susceptibility results in invasive group A Streptococcus isolates, by emm type and resistance determinant, West Virginia, USA, 2020–2021*

emm type Geno, no. No. (%)
Erythromycin
Clindamycin
Tetracycline
Kanamycin
Streptomycin
Gentamicin
S R S iMLSB cMLSB S R S R S R S R
emm92
ermT, 35
0
35 (100)

0
31 
(89)
4 
(11)

0
35 (100)

0
35 (100)

0
35 (100)

35 (100)
0
emm11
ermA, 2 0 2 (100) 0 2 
(100) 0 0 2 (100) 0 2 (100) 2 (100) 0 2 (100) 0
ermB, 6
0
6 (100)

0
3 
(50)
3 
(50)


6 (100)

2 
(33)
4 
(67)

0
6 (100)

6 (100)
0
emm77
ermA, 1 0 1 (100) 0 1 
(100) 0 0 1 (100) 0 1 (100) 1 (100) 0 1 (100) 0
ND, 1
1 (100)
0

1 (100)
0
0

1 (100)
0

0
1 (100)

1 (100)
0

1 (100)
0
emm83
ermA, 3
0
3 (100)

0
3 
(100)
0

0
3 (100)

0
3 (100)

2 
(67)
1 
(33)

3 (100)
0
emm197
ermA, 1
0
1 (100)

0
0
1 
(100)

0
1 (100)

1 (100)
0

1 (100)
0

1 (100)
0
emm82
ermB, 1
0
1 (100)

0
0
1 
(100)

0
1 (100)

1 (100)
0

1 (100)
0

1 (100)
0
emm22
mefA, 1
0
1 (100)

1 (100)
0
0

0
1 (100)

1 (100)
0

1 (100)
0

1 (100)
0
emm89
ND, 5
5 (100)
0

5 (100)
0
0

5 (100)
0

NT


NT

5 (100)
0
emm
ND, 10
10 (100)
0

10 (100)
0
0

9 (90)
1 
(10)

2 
(20)
8 
(80)

9 
(90)
1 
(10)

10 (100)
0
Total = 66
16 (24) 50 (76) 17 (25) 40 
(61) 9 
(14) 15 (23) 51 (77) 7 
(11) 54 (89) 24 (39) 37 (61) 66 (100) 0

*Geno, genotype; ND, resistance gene not detected; NT, not tested; R, resistant; S, susceptible. †One emm11 isolate was not inducible by D-test but showed intermediate clindamycin resistance; other emm types with no erm: emm1 (2), emm2 (1), emm12 (1), emm28 (1), emm75 (1), emm81 (3), emm87 (1).

Main Article

1These senior authors contributed equally to this article.

Page created: March 06, 2023
Page updated: April 14, 2023
Page reviewed: April 14, 2023
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