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Volume 25, Number 4—April 2019
Research

Symptoms, Sites, and Significance of Mycoplasma genitalium in Men Who Have Sex with Men

Tim R.H. Read, Gerald L. Murray, Jennifer A. Danielewski, Christopher K. Fairley, Michelle Doyle, Karen Worthington, Jenny Su, Elisa Mokany, L.T. Tan, David Lee, Lenka A. Vodstrcil, Eric P.F. Chow, Suzanne M. Garland, Marcus Y. Chen, and Catriona S. BradshawComments to Author 
Author affiliations: Melbourne Sexual Health Centre, Carlton, Victoria, Australia (T.R.H. Read, C.K. Fairley, M. Doyle, K. Worthington, D. Lee, L.A. Vodstrcil, E.P.F. Chow, M.Y. Chen, C.S. Bradshaw); Monash University, Melbourne, Victoria, Australia (T.R.H. Read, C.K. Fairley, L.A. Vodstrcil, E.P.F. Chow, M.Y. Chen, C.S. Bradshaw); Monash Biomedicine Discovery Institute, Melbourne (G.L. Murray); Murdoch Children’s Research Institute, Parkville, Victoria, Australia (G.L. Murray, J.A. Danielewski, J. Su, S.M. Garland); Royal Women’s Hospital, Melbourne (G.L. Murray, J.A. Danielewski, S.M. Garland); Royal Children’s Hospital, Melbourne (G.L. Murray, S.M. Garland); SpeeDx Pty Ltd, Eveleigh, Sydney, New South Wales, Australia (E. Mokany, L.T. Tan); University of Melbourne, Melbourne (S.M. Garland)

Main Article

Table 2

Detection of urethral or rectal Chlamydia trachomatis or Neisseria gonorrhoeae in asymptomatic men who have sex with men, Australia*

Characteristic
All patients
C. trachomatis not detected
C. trachomatis detected†
N. gonorrhoeae not detected
N. gonorrhoeae detected†
Detected in urine, rectum, or both
STI prevalence 1,001 857 (90.4) 91 (9.6, 7.8–11.7) 888 (93.3) 64 (6.7, 5.2–8.5)
Median age, y (IQR) 28.8 (24.3–34.1) 28.8 (24.3–34.0) 27.6 (23.8–35.2) 28.8 (24.3–34.1) 27.2 (24.1–33.1)
HIV status
Negative‡ 894 782 (91.3) 72 (79.1) 801 (90.2) 55 (85.9)
Positive 107 75 (8.8) 19 (20.9) 87 (9.8) 9 (14.1)
On/commencing PrEP§
No 752 666 (85.2) 57 (79.2) 683 (85.3) 39 (70.9)
Yes
142
116 (14.8)
15 (20.8)
118 (14.7)
16 (29.1)
Detected in urine only
Urine prevalence 958 942 (98.3) 16 (1.7, 1.0–2.7) 951 (99.3) 7 (0.7, 0.3–1.4)
Insertive oral sex partners in previous 3 mo, n = 984¶
<4 431 407 (44.0) 4 (25.0) 408 (43.6) 2 (28.6)
>4 553 519 (56.0) 12 (75.0) 527 (56.4) 5 (71.4)
Insertive anal sex partners in previous 3 mo, n = 941#
<2 428 406 (45.9) 4 (25.0) 409 (45.8) 0
>2 513 479 (54.1) 12 (75.0) 485 (54.2) 7 (100)
Condom use insertive anal sex in previous 3 mo
Always 287 273 (39.1) 5 (31.3) 273 (38.6) 4 (57.1)
Not always
460
425 (60.9)
11 (68.7)
434 (61.4)
3 (42.9)
Detected in rectum only
Rectal prevalence 958–963 877 (91.5) 81 (8.5, 6.8–10.4) 903 (93.8) 60 (6.2, 4.8–7.9)
Receptive anal sex partners in previous 3 mo, n = 945#
<2 367 336 (40.8) 20 (24.7) 342 (40.1) 15 (26.3)
>2 578 488 (59.2) 61 (75.3) 511 (59.9) 42 (73.7)
Condom use receptive anal sex in previous 3 mo
Always 301 270 (37.1) 18 (23.4) 277 (36.7) 11 (20.0)
Not always 540 458 (62.9) 59 (76.6) 477 (63.3) 44 (80.0)

*Values are no. (%) or no. (%, 95% CI) except as indicated. This table should be viewed in conjunction with Table 1. All 1,001 men had urine and rectal swabs tested for Mycoplasma genitalium, but only 948 were tested at both sites for C. trachomatis and 952 for N. gonorrhoeae. IQR, interquartile range; PrEP, preexposure prophylaxis.
†Denominators varied based on numbers tested; 958 men had urine tests for both infections; 948 men were screened at both sites and 958 men had rectal tests for C. trachomatis; and 952 men were screened at both sites and 963 men had rectal tests for N. gonorrhoeae.
‡Includes 5 men of unknown HIV infection status. M. genitalium was detected in 4.7% of HIV-positive men vs. 10.1% of HIV-negative men (p = 0.08).
§HIV-negative men only.
¶Median 4.
#Median 2.

Main Article

Page created: March 18, 2019
Page updated: March 18, 2019
Page reviewed: March 18, 2019
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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