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Viral hemorrhagic fevers (VHFs)

VHF Virus Families

VHFs are caused by viruses of five distinct families: Arenaviridae, Bunyaviridae, Filoviridae, Flaviviridae, and Paramyxoviridae. Each of these families share a number of features:

  • They are all RNA viruses, and are all covered, or enveloped, in a fatty (lipid) coating.
  • Their survival is dependent on an animal or insect host, called the natural reservoir.
  • The viruses are geographically restricted to the areas where their host species live.
  • Humans are not the natural reservoir for any of these viruses. Humans are infected when they come into contact with infected hosts. However, with some viruses, after the accidental transmission from the host, humans can transmit the virus to one another.
  • Human cases or outbreaks of hemorrhagic fevers caused by these viruses occur sporadically and irregularly. The occurrence of outbreaks cannot be easily predicted.
  • With a few noteworthy exceptions, there is no cure or established drug treatment for VHFs.

In rare cases, other viral and bacterial infections can cause a hemorrhagic fever; scrub typhus is a good example.

Arenaviridae

Transmission electron micrograph depicting eight viral particles of a virus belonging to the Arenavirus genus.

The Arenaviridae are a family of viruses whose members are generally associated with rodent-transmitted diseases in humans.

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Filoviridae

Colorized negative stained transmission electron micrograph depicting a Marburg virus virion, in the filovirus family.

Filoviruses belong to a virus family called Filoviridae and can cause severe hemorrhagic fever in humans and nonhuman primates.

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Bunyaviridae

Negatively stained transmission electron micrograph depicting Sin Nombre virus virions, belonging to the genus Hantavirus within the family Bunyaviridae.

The Bunyaviridae are a very large family of single-strand, enveloped RNA viruses (more than 300 viruses) and consists of five genera of viruses.

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Flaviviridae

Digitally-colorized transmission electron micrograph of the West Nile virus, in the flavivirus family.

The Flaviviridae are a family of positive, single-stranded, enveloped RNA viruses. They are found in arthropods, (primarily ticks and mosquitoes), and can occasionally infect humans.

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Paramyxoviridae

Transmission electron micrograph of Nipah virus nucleocapsid, in the Paramyxoviridae family of viruses.

The Paramyxoviridae are a large family of single-strand, enveloped RNA viruses which causes a number of human and animal diseases.

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