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Federal Tuberculosis Task Force Plan in Response to the Institute
of Medicine Report, Ending Neglect: The Elimination of Tuberculosis
in the United States
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Executive Summary
Introduction
After years of decline in the United States, the number of reported
tuberculosis (TB) cases increased 20% between 1985 and 1992. This
resurgence was associated with a deterioration of the infrastructure
for TB services; the human immunodeficiency virus (HIV) epidemic,
which substantially increases the risk for active TB among persons
with latent TB infection (LTBI); increased immigration of persons
from countries where TB is endemic; TB transmission in congregate
settings (e.g., hospitals and prisons); and development of multidrug-resistant
TB (MDR TB). However, a renewed emphasis on TB control and prevention
and a major commitment of resources in the mid- to late 1990s resulted
in substantial declines in the disease. In 2000, the number of TB
cases decreased for the eighth straight year to an all-time low
of 16,377 cases, a 7% decrease over the 17,531 cases reported in
1999.
In the summer of 2000, the National Academy of Sciences’ Institute
of Medicine (IOM) issued a report, Ending Neglect: The Elimination
of Tuberculosis in the United States.1
The report states that the resurgence of TB in the United States
was the price of neglect reflected in earlier funding reductions
and concludes that, with proper funding, organization of prevention
and control activities, and research for development of new tools,
TB can be eliminated as a public health problem in the United States.
In response, the Federal TB Task Force developed this plan to implement
the IOM recommendations. The plan is organized around the five areas
of IOM recommendations and provides a blueprint for a significant
reduction in the remaining U.S. TB cases. The plan includes domestic
and global strategies — planned for implementation in partnership
with global agencies such as the World Health Organization (WHO)
and the International Organization of Migration — as well as detailed
action steps and specific agency roles.
Chronology in the Development of This Report
In responding to the IOM report, members of the Federal TB Task
Force met to develop a coordinated federal action plan. Two meetings
were convened in Bethesda, Maryland, on December 6-7, 2000, and
February 8-9, 2001, to initiate the development of this plan.
A consensus was reached in determining the lead agencies and collaborating
agencies for each activity. Individual recommendations revolving
around common activities were consolidated, and a consensus was
reached on the resulting list by circulating drafts to the entire
task force. In the next step, lead individuals were identified for
the lead agencies. These persons worked with named co-leads and
collaborating agencies to further develop the strategies by adding
additional action steps where deemed necessary to implement the
strategies. Subsequent drafts of the entire document were shared
with the Federal TB Task Force participants who provided comments,
where appropriate, for the next draft. The final draft was discussed
at a Federal TB Task Force conference call in late August 2001,
where remaining issues were resolved. This was followed by a series
of additional participant reviews accomplished by circulation of
the drafts to participants. Because of the unusual multiagency nature
of this document, this final document went through high-level multiagency
clearance before publication.
Strategies for Eliminating Tuberculosis
The IOM recommended five overarching strategies for eliminating
TB. The first strategy, maintaining control of TB, is a necessary
prerequisite to elimination of the disease and requires strengthening
of labor-intensive activities that make optimal use of available
tools to help find and cure all persons with active TB. The IOM’s
second strategy is to accelerate the decline of TB. Maintaining
control of TB is not sufficient to eliminate TB; individuals can
unknowingly carry live bacteria that cause TB for years without
getting sick (also known as latent TB infection). An estimated 10
to 15 million persons in the United States have latent TB infection,
many of them in identifiable but hard-to-reach populations. Latent
TB infection can suddenly turn active and contagious. Finding and
treating high-risk persons with latent TB infection before they
become sick — and infectious — is absolutely essential to eliminating
TB. High-risk persons include those with recent infection, contacts
of persons with infectious TB, persons with HIV or AIDS, substance
abusers, persons who have immigrated to the United States from areas
of the world with high rates of TB, prisoners, and the homeless.
In addition, persons who reside or work in institutional settings
(e.g., hospitals, homeless shelters, correctional facilities, nursing
homes, and residential homes for patients with AIDS) may have an
ongoing risk for acquiring TB infection and disease.
Thirdly, the IOM recommends the development of new tools. The goal
of TB elimination cannot be reached with the tools that are currently
available. TB elimination will require an increased investment in
TB research to develop a more effective vaccine, as well as new
tools and drugs to more rapidly and reliably diagnose and shorten
treatment for all persons with latent and active TB, including those
afflicted with MDR TB. The fourth IOM strategy calls for increased
global United States actions. The IOM report notes that the proportion
of foreign-born TB cases in the United States has been steadily
increasing and says it benefits the United States to help strengthen
TB control programs globally. Specifically, page 11 of the IOM report
states that "Tuberculosis will not be eliminated in the United
States until the worldwide pandemic is brought under control."
Finally, the IOM recommends an assessment of the impact of actions
taken in response to the IOM report. The Advisory Council for the
Elimination of Tuberculosis (ACET) and the Federal TB Task Force
will monitor the federal response to the IOM report.
In response to these recommendations, the Federal TB Task Force
developed the action steps contained in this document. Specific
tasks and projects are described, and agencies with the lead responsibility
for each step, along with estimated start and completion dates,
are provided.
Conclusion
While the strategies and action steps complement ongoing federal
TB prevention, control, and research activities, they cannot all
be implemented with current funding. Federal TB Task Force agencies
will implement the strategies and action steps contained in this
report as resources become available. Federal TB Task Force members
continue to confer via teleconference on a quarterly basis and remain
ready to provide a coordinated federal response to the IOM recommendations
and to progress toward TB elimination in the United States.
Last Reviewed: 05/18/2008 Content Source: Division of Tuberculosis Elimination
National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention
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