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Table 3. Recommended doses of currently licensed formulations of adolescent and adult hepatitis B vaccines

Sexually Transmitted Diseases Treatment Guidelines, 2010

GroupSingle-antigen vaccineCombination vaccine
Recombivax HBEngerix-BTwinrix*
Dose (µg) Volume (mL)Dose (µg) Volume (mL)Dose (µg) Volume (mL)
Adolescents aged 11–19 years§50.5100.5NANA
Adolescents aged 11–15 years¶101.0NANANANA
Adults (aged ≥20 years)101.0201.0201.0
Hemodialysis patients and other immunocompromised persons aged < 20 years§50.5100.5NANA
Hemodialysis patients and other immunocompromised persons aged ≥20 years40**1.040††2.0NANA


Sources: CDC. A comprehensive immunization strategy to eliminate transmission of hepatitis B virus infection in the United States: recommendations of the Advisory Committee on Immunization Practices (ACIP) Part 1: immunization of infants, children, and adolescents. MMWR 2005;54(No. RR-16). CDC. A comprehensive immunization strategy to eliminate transmission of hepatitis B virus infection in the United States: recommendations of the Advisory Committee on Immunization Practices (ACIP) Part II: immunization of adults. MMWR 2006;55(No. RR-16).
* Combined hepatitis A and hepatitis B vaccine. This vaccine is recommended for persons aged ≥18 years who are at increased risk for both hepatitis B and hepatitis A virus infections.
† Recombinant hepatitis B surface antigen protein dose, in micrograms.
§ Pediatric formulation administered on a 3-dose schedule; higher doses might be more immunogenic, but no specific recommendations have been made.
¶ Adult formulation administered on a 2-dose schedule.
** Dialysis formulation administered on a 3-dose schedule at 0, 1, and 6 months.
†† Two 1.0-mL doses of the adult formulation administered at one site on a 4-dose schedule at 0, 1, 2, and 6 months.

 
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