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2013 Interpretive Criteria for Neisseria gonorrhoeae Susceptibility Testing

The following are zone diameter interpretive standards and equivalent minimal inhibitory concentration (MIC) breakpoints* for Neisseria gonorrhoeae according to the Clinical and Laboratory Standards Institute (Performance Standards for Antimicrobial Susceptibility Testing; Twenty-Third Informational Supplement, January 2013, M100-S23 Vol 33 No 1::

*At this time, no interpretive criteria exists for Azithromycin and Levofloxacin

Antimicrobial Agent Zone Diameter
(nearest whole mm)
Equivalent MIC Breakpoints
(µg/mL)
R I S R S

Penicillins

Penicillin<=2627-46>=47>=2<=0.06

Cephems (Parenteral)

Cefotaxime-->=31-<=0.5
Ceftizoxime-->=38-<=0.5
Ceftriaxone-->=35-<=0.25

Cefmetazole

<=2728-32>=33>=8<=2
Cefotetan<=1920-25>=26>=8<=2
Cefoxitin<=2324-27>=28>=8<=2
Cefuroxime sodium (parenteral)<=2526-30>=31>=4<=1

Cefepime

-->=31-<=0.5

Ceftazidime

-->=31-<=0.5

Cephems (Oral)

Cefixime-->=31-<=0.25

Cefpodoxime

-->=29-<=0.5

Cefetamet

-->=29-<=0.5

Tetracyclines

Tetracycline

<=3031-37>=38>=2<=0.25

Fluoroquinolones

Ciprofloxacin

<=2728-40>=41>=1<=0.06
Gatifloxacin<=3334-37>=38>=0.5<=0.12
Ofloxacin<=2425-30>=31>=2<=0.25

Enoxacin

<=3132-35>=36>=2<=0.5

Grepafloxacin

<=2728-36>=37>=1<=0.06

Lomefloxacin

<=2627-37>=38>=2<=0.12

Trovafloxacin

-->=34-<=0.25

Fleroxacin

<=2829-34>=35>=1<=0.25

Aminocyclitols

Spectinomycin

<=1415-17>=18>=128<=32

 
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