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2013 Interpretive Criteria for Neisseria gonorrhoeae Susceptibility Testing

The following are zone diameter interpretive standards and equivalent minimal inhibitory concentration (MIC) breakpoints* for Neisseria gonorrhoeae according to the Clinical and Laboratory Standards Institute (Performance Standards for Antimicrobial Susceptibility Testing; Twenty-Third Informational Supplement, January 2013, M100-S23 Vol 33 No 1::

*At this time, no interpretive criteria exists for Azithromycin and Levofloxacin

 

Antimicrobial Agent Zone Diameter
(nearest whole mm)
Equivalent MIC Breakpoints
(µg/mL)
R I S R S

Penicillins

Penicillin <=26 27-46 >=47 >=2 <=0.06

Cephems (Parenteral)

Cefotaxime - - >=31 - <=0.5
Ceftizoxime - - >=38 - <=0.5
Ceftriaxone - - >=35 - <=0.25

Cefmetazole

<=27 28-32 >=33 >=8 <=2
Cefotetan <=19 20-25 >=26 >=8 <=2
Cefoxitin <=23 24-27 >=28 >=8 <=2
Cefuroxime sodium (parenteral) <=25 26-30 >=31 >=4 <=1

Cefepime

- - >=31 - <=0.5

Ceftazidime

- - >=31 - <=0.5

Cephems (Oral)

Cefixime - - >=31 - <=0.25

Cefpodoxime

- - >=29 - <=0.5

Cefetamet

- - >=29 - <=0.5

Tetracyclines

Tetracycline

<=30 31-37 >=38 >=2 <=0.25

Fluoroquinolones

Ciprofloxacin

<=27 28-40 >=41 >=1 <=0.06
Gatifloxacin <=33 34-37 >=38 >=0.5 <=0.12
Ofloxacin <=24 25-30 >=31 >=2 <=0.25

Enoxacin

<=31 32-35 >=36 >=2 <=0.5

Grepafloxacin

<=27 28-36 >=37 >=1 <=0.06

Lomefloxacin

<=26 27-37 >=38 >=2 <=0.12

Trovafloxacin

- - >=34 - <=0.25

Fleroxacin

<=28 29-34 >=35 >=1 <=0.25

Aminocyclitols

Spectinomycin

<=14 15-17 >=18 >=128 <=32

 
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