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General Information

Frequently Asked Questions

Definitions & Symptoms

What is Shigella?

Shigellosis is a diarrheal disease caused by a group of bacteria called Shigella. Shigella causes about 500,000 cases of diarrhea in the United States annually 1. There are four different species of Shigella:

  • Shigella sonnei (the most common species in the United States)
  • Shigella flexneri
  • Shigella boydii
  • Shigella dysenteriae

S. dysenteriae and S. boydii are rare in the United States, though they continue to be important causes of disease in the developing world. Shigella dysenteriae type 1 can cause deadly epidemics 2.

What are the symptoms of Shigella?

Symptoms of shigellosis typically start 1–2 days after exposure and include:

  • Diarrhea (sometimes bloody)
  • Fever
  • Abdominal pain
  • Tenesmus (a painful sensation of needing to pass stools even when bowels are empty)

How long after infection do symptoms appear?

Symptoms of shigellosis generally begin 1 to 2 days after becoming infected with the bacteria.

How long will symptoms last?

In persons with healthy immune systems, symptoms usually last about 5 to 7 days. Persons with diarrhea usually recover completely, although it may be several months before their bowel habits are entirely normal. Once someone has had shigellosis, they are not likely to get infected with that specific type again for at least several years. However, they can still get infected with other types of Shigella.

Can there be any complications from Shigella infections?

Possible complications from Shigella infections include:

  • Post-infectious arthritis. About 2% of persons who are infected with Shigella flexneri later develop pains in their joints, irritation of the eyes, and painful urination. This is called post-infectious arthritis. It can last for months or years, and can lead to chronic arthritis. Post-infectious arthritis is caused by a reaction to Shigella infection that happens only in people who are genetically predisposed to it 2.
  • Blood stream infections. Although rare, blood stream infections are caused either by Shigella organisms or by other germs in the gut that get into the bloodstream when the lining of the intestines is damaged during shigellosis. Blood stream infections are most common among patients with weakened immune systems, such as those with HIV, cancer, or severe malnutrition 2.
  • Seizures. Generalized seizures have been reported occasionally among young children with shigellosis, and usually resolve without treatment. Children who experience seizures while infected with Shigella typically have a high fever or abnormal blood electrolytes (salts), but it is not well understood why the seizures occur 2.
  • Hemolytic-uremic syndrome or HUS. HUS occurs when bacteria enter the digestive system and produce a toxin that destroys red blood cells. Patients with HUS often have bloody diarrhea. HUS is only associated with Shiga-toxin producing Shigella, which is found most commonly in Shigella dysenteriae 2.

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Diagnosis & Testing

How can Shigella infections be diagnosed?

Many different kinds of germs can cause diarrhea, so establishing the cause will help guide treatment. Healthcare providers can order laboratory tests to identify Shigella in the stools of an infected person. The laboratory can also do special tests to determine which antibiotics, if any, would be best to treat the infection.

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Treatment

How can Shigella infections be treated?

Diarrhea caused by Shigella usually resolves without antibiotic treatment in 5 to 7 days. People with mild shigellosis may need only fluids and rest. Bismuth subsalicylate (e.g., Pepto-Bismol®) may be helpful 3, 4, but medications that cause the gut to slow down, such as loperamide (e.g., Imodium®) or diphenoxylate with atropine (e.g., Lomotil®), should be avoided 5. Antibiotics are useful for severe cases of shigellosis because they can reduce the duration of symptoms 6. However, Shigella is often resistant to antibiotics. If you require antibiotic treatment for shigellosis, your healthcare provider can culture your stool and determine which antibiotics are likely to work. Tell your healthcare provider if you do not get better within a couple of days after starting antibiotics. He or she can do additional tests to learn whether your strain of Shigella is resistant to the antibiotic you are taking.

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Antibiotic Resistance

Is antibiotic resistance a problem with Shigella?

In 2013, CDC declared antibiotic-resistant Shigella an urgent threat in the United States 7. Resistance to traditional first-line antibiotics like ampicillin and trimethoprim-sulfamethoxazole is common among Shigella globally, and resistance to some other important antibiotics is increasing 8-13. While travelers to the developing world are at particular risk of acquiring antibiotic-resistant shigellosis, outbreaks of shigellosis resistant to ciprofloxacin or azithromycin—the two antibiotics most commonly used to treat shigellosis—have been reported recently within the United States and other industrialized countries 14-18. About 27,000 Shigella infections in the United States every year are resistant to one or both of these antibiotics 7. When pathogens are resistant to common antibiotic medications, patients may need to be treated with medications that may be less effective, but more toxic and expensive. To learn more about antibiotic resistance, see Antibiotic / Antimicrobial Resistance.

How will I know if I have an antibiotic-resistant Shigella infection?

Shigella infections are diagnosed through laboratory testing of stool specimens (feces). Healthcare providers can order tests to check which antibiotics are likely to help treat a particular patient’s infection. If you were treated with antibiotics for shigellosis but do not feel better within a couple of days, tell your healthcare provider. You may need additional tests to check whether your Shigella strain is resistant to the antibiotics.

What should I do if I have an antibiotic-resistant Shigella infection?

Please follow the advice of your healthcare provider. If you do not feel better within a couple of days after beginning treatments, tell your healthcare provider. Protect others by washing your hands carefully with soap after using the toilet, and wait until your diarrhea has stopped before preparing food for others, swimming, or having sex.

How can we reduce the spread of antibiotic-resistant Shigella?

Reducing the spread of antibiotic-resistant Shigella requires a multi-pronged approach: preventing infections, tracking resistance, improving antibiotic use, and developing new treatments 7. For more information, see Antibiotic Resistance Threats in the United States, 2013. [PDF - 114 pages].

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Transmission

How is Shigella spread?

Shigella germs are present in the stools of infected persons while they have diarrhea and for up to a week or two after the diarrhea has gone away. Shigella is very contagious; exposure to even a tiny amount of contaminated fecal matter—too small to see-- can cause infection. Transmission of Shigella occurs when people put something in their mouths or swallow something that has come into contact with stool of a person infected with Shigella. This can happen when:

  • Contaminated hands touch your food or mouth. Hands can become contaminated through a variety of activities, such as touching surfaces (e.g., toys, bathroom fixtures, changing tables, diaper pails) that have been contaminated by stool from an infected person. Hands can also become contaminated with Shigella while changing the diaper of an infected child or caring for an infected person.
  • Eating food contaminated with Shigella. Food may become contaminated if food handlers have shigellosis. Produce can become contaminated if growing fields contain human sewage. Flies can breed in infected feces and then contaminate food when they land on it.
  • Swallowing recreational (for example lake or river water while swimming) or drinking water that was contaminated by infected fecal matter.
  • Exposure to feces through sexual contact.

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Prevention

How can I reduce my risk of getting shigellosis?

Currently, there is no vaccine to prevent shigellosis. However, you can reduce your risk of getting shigellosis by:

  • Carefully washing your hands with soap during key times:
    • Before eating.
    • After changing a diaper or helping to clean another person who has defecated (pooped).
  • If you care for a child in diapers who has shigellosis, promptly discard the soiled diapers in a lidded, lined garbage can, and wash your hands and the child’s hands carefully with soap and water immediately after changing the diapers. Any leaks or spills of diaper contents should be cleaned up immediately.
  • Avoid swallowing water from ponds, lakes, or untreated swimming pools.
  • When traveling internationally, follow food and water precautions strictly and wash hands with soap frequently. For more information, see Travelers' Health - Food and Water Safety.
  • Avoid sexual activity with those who have diarrhea or who recently recovered from diarrhea. For more information, see Shigella Infections among Gay & Bisexual Men.

I was diagnosed with shigellosis. What can I do to avoid giving it to other people?

  • Wash your hands with soap carefully and frequently, especially after using the toilet.
  • Do not prepare food for others while you are sick. After you get better, wash your hands carefully with soap before preparing food for others.
  • For those who work in healthcare, food service, or childcare facilities should not prepare or handle food for others until their local health department has authorized them to return to work. Improvements in worker sick leave policies and providing adequate hygiene facilities and education for food service workers may prevent shigellosis caused by contaminated foods.
  • Avoid swimming until you have fully recovered.
  • Don’t have sex until several days after you no longer have diarrhea.

My child was diagnosed with shigellosis. How can I keep others from catching it?

  • Supervise handwashing of toddlers and small children after they use the toilet. Wash infants’ hands with soap and water after diaper changes.
  • Dispose of soiled diapers properly, and clean diaper changing areas after using them.
  • Keep the child out of childcare and group play settings while ill with diarrhea, and follow the guidance of your local health department about returning your child to his or her childcare facility.
  • Avoid taking your child swimming or to group water play venues until after he or she has fully recovered.

Should an infected person be excluded from school or work?

School and work exclusion policies differ by local jurisdiction. Check with your local or state health department to learn more about the laws where you live. It is critical to practice good hand-washing after changing diapers, after using the toilet, and before preparing or eating food to prevent the spread of these and many other infections.

What else can be done to prevent shigellosis?

  • Providing municipal water service, this may be lacking in many lower income countries. Making municipal water supplies available and safe and treating sewage are highly effective prevention measures that have been in place for many years.
  • Following these guidelines to make your food safer to eat. People with shigellosis should not prepare food or drinks for others until they are well. Food service workers should not prepare or handle food for others until their local health department has authorized them to return to work. Improvements in worker sick leave policies and providing adequate hygiene facilities and education for food service workers may prevent shigellosis caused by contaminated foods.
  • At swimming beaches, providing enough bathrooms and handwashing stations with soap near the swimming area helps keep the water from becoming contaminated. For more information, see Swimming Hygiene.

What can be done if an outbreak of Shigella occurs in the childcare setting?

  • Exclude any child with diarrhea from the childcare setting until the diarrhea has stopped.
    • Children who have recently recovered from shigellosis can be grouped together in one classroom (cohorted) to minimize exposing uninfected children and staff to Shigella.
  • Assign separate staff to change diapers and prepare or serve food.
  • Reassign adults with diarrhea to jobs that minimize opportunities for spreading infection (for example, administrative work instead of food preparation).
  • Establish, implement, and enforce policies on water-play and swimming that:
    • Exclude children ill with diarrhea from water-play and swimming activities.
    • Exclude children diagnosed with Shigella from water-play and swimming activities for an additional week after their diarrhea has resolved.
    • Have children and staff wash their hands before using water tables.
    • Have children and staff shower with soap before swimming in the water.
      • If a child is too young to shower independently, have staff wash the child, particularly the rear end, with soap and water.
    • Take frequent bathroom breaks or check their diapers often.
      • Change children’s diapers in a diaper-changing area or bathroom and not by the water.
    • Discourage children from getting the water in their mouths and swallowing it.
    • Prohibit the use of temporary inflatable or rigid fill-and-drain swimming pools and slides because they can spread germs in childcare facilities.

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People at Risk

People at Risk

  • Young children are the most likely to get shigellosis, but people from all age groups are affected 19. Many outbreaks are related to childcare settings and schools, and illness commonly spreads from young children to their family members and others in their communities because it is so contagious.
  • Gay, bisexual, and other men who have sex with men (MSM) are more likely to acquire shigellosis than the general adult population 20. Shigella passes from stools [poop] or soiled fingers of one person to the mouth of another person, which can happen during sexual activity. Many shigellosis outbreaks among MSM have been reported in the United States, Canada, Tokyo, and Europe since 1999 8, 15, 16, 18, 21, 22. For more information, see Shigella Infections among Gay & Bisexual Men.
  • HIV-infected persons can have more severe and prolonged shigellosis, including having the infection spread into the blood, which can be life-threatening 23.
  • Large outbreaks of Shigella have occurred in traditionally observant Jewish communities 24-26. Documented outbreaks in traditionally observant Jewish communities often begin in childcare settings and spread within and between households during social gatherings.
  • Travelers to developing countries may be more likely to get shigellosis, and to become infected with strains of Shigella that are resistant to important antibiotics 27, 28. Travelers may be exposed through contaminated food, water (both drinking and recreational water), or surfaces. Travelers can protect themselves by strictly following food and water precautions, and washing hands with soap frequently. For more information, see Travelers' Health - Food and Water Safety. 

The term men who have sex with men is used in CDC surveillance systems because it indicates the behaviors that transmit Shigella infection, rather than how individuals self-identify in terms of their sexuality.

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Statistics

Estimates

Every year, there are about 500,000 cases of shigellosis in the United States 1. Shigellosis does not have a marked seasonality, likely reflecting the importance of person-to-person transmission. For more information, see the FoodNet 2011 Surveillance Report.[PDF - 53 pages] 

Incidence

In 2013, the average annual incidence of shigellosis in the United States was 4.82 cases per 100,000 individuals 29.

Trends

Shigella infections have not declined appreciably over the past 10 years. The incidence rate of infection with Shigella sonnei decreased from 2008 through 2011, but increased in 2012 30, 31.

Antibiotic Resistance

Resistance to traditional first-line drugs such as ampicillin and trimethoprim-sulfamethoxazole is common. Healthcare providers now rely on alternative drugs like ciprofloxacin and azithromycin to treat infections. However, strains of Shigella resistant to these antibiotics are becoming more common in the United States. Infections caused by antibiotic-resistant Shigella strains can last longer than infections caused by antibiotic-susceptible bacteria (bacteria that can be treated effectively with antibiotics) 7. Because initial treatment can fail, costs are expected to be higher for resistant infections 7. For more information, see Antibiotic / Antimicrobial Resistance.

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Educational Resources

General Public

  • If you or your child have diarrhea, find more information to protect yourself, your family, and your community, as well as steps to get better.
  • Handwashing is the #1 way to protect yourself against Shigella infections. Please see the CDC handwashing website for more information.

Childcare Settings

MSM

Swimming Hygiene

Traditionally Observant Jews

Food Service

Below you will find useful links related to hygiene and handwashing in the food service industry.

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References
  1. Scallan E, Hoekstra RM, Angulo FJ, Tauxe RV, Widdowson MA, Roy SL, Jones JL, Griffin PM. Foodborne illness acquired in the United States--major pathogens. Emerg Infect Dis. 2011;17(1):7-15.
  2. American Academy of Pediatrics. Red Book: Report of the Committee on Infectious Diseases. 2012. 645-647.
  3. Pathophysiology of gastrointestinal infections: the role of bismuth subsalicylate. Scottsdale, Arizona, 11-14 February 1988. Proceedings. Rev Infect Dis. 1990;12 Suppl 1:S1-119.
  4. Steffen R. Worldwide efficacy of bismuth subsalicylate in the treatment of travelers' diarrhea. Rev Infect Dis. 1990;12 Suppl 1:S80-6.
  5. DuPont HL, Hornick RB. Adverse effect of lomotil therapy in shigellosis. JAMA. 1973;226(13):1525-8.
  6. Christopher PR, David KV, John SM,and Sankarapandian V. Antibiotic therapy for Shigella dysentery. Cochrane Database Syst Rev. 2010;(8):CD006784.
  7. CDC. Antibiotic resistance threats in the United States, 2013. [PDF - 114 pages]
  8. Heiman KE, Karlsson M, Grass J, Howie B, Kirkcaldy RD, Mahon B, Brooks JT, Bowen A. Notes from the field: Shigella with decreased susceptibility to azithromycin among men who have sex with men - United States, 2002-2013. MMWR Morb Mortal Wkly Rep. 2014;63(6):132-3.
  9. CDC. National Antimicrobial Resistance Monitoring System: Enteric Bacteria 2012. [PDF - 88 pages]
  10. Bhattacharya D, Bhattacharya H, Sayi DS, Bharadwaj AP, Singhania M, Sugunan AP, Roy S. Changing patterns and widening of antibiotic resistance in Shigella spp. over a decade (2000-2011), Andaman Islands, India. Epidemiol Infect. 2015;143(3):470-7.
  11. Iversen J, Sandvang D, Srijan A, Cam PD, Dalsgaard A. Characterization of antimicrobial resistance, plasmids, and gene cassettes in Shigella spp. from patients in vietnam. Microb Drug Resist. 2003;9 Suppl 1:S17-24.
  12. Zhang J, Jin H, Hu J, Yuan Z, Shi W, Yang X, Xu X, Meng J. Antimicrobial resistance of Shigella spp. from humans in Shanghai, China, 2004-2011. Diagn Microbiol Infect Dis. 2014;78(3):282-6.
  13. Ghosh S, Pazhani GP, Chowdhury G, Guin S, Dutta S, Rajendran K, Bhattacharya MK, Takeda Y, Niyogi SK, Nair GB, Ramamurthy T. Genetic characteristics and changing antimicrobial resistance among Shigella spp. isolated from hospitalized diarrhoeal patients in Kolkata, India. J Med Microbiol. 2011;60(Pt 10):1460-6.
  14. CDC. Outbreak of infections caused by Shigella sonnei with decreased susceptibility to azithromycin – Los Angeles, California, 2012. MMWR Morbid Mortal Wkly Rep. 2013 Mar 8;62(9):171.
  15. Gaudreau C, Barkati S, Leduc JM, Pilon PA, Favreau J, Bekal S. Shigella spp. with reduced azithromycin susceptibility, Quebec, Canada, 2012-2013. Emerg Infect Dis. 2014;20(5):854-6.
  16. Gaudreau C, Ratnayake R, Pilon PA, Gagnon S, Roger M, Levesque S. Ciprofloxacin-resistant Shigella sonnei among men who have sex with men, Canada, 2010. Emerg Infect Dis. 2011;17(9):1747-50.
  17. Hoffmann C, Sahly H, Jessen A, Ingiliz P, Stellbrink HJ, Neifer S, Schewe K, Dupke S, Baumgarten A, Kuschel A, Krznaric I. High rates of quinolone-resistant strains of Shigella sonnei in HIV-infected MSM. Infection. 2013;41(5):999-1003.
  18. Morgan O, Crook P, Cheasty T, Jiggle B, Giraudon I, Hughes H, Jones SM. Shigella sonnei outbreak among homosexual men, London. Emerg Infect Dis. 2006;12(9):1458-60.
  19. Adams DA, Jajosky RA, Ajani U, Kriseman J, Sharp P, Onwen DH, Schley AW, Anderson WJ, Grigoryan A, Aranas AE, Wodajo MS, Abellera JP. Summary of notifiable diseases--United States, 2012. MMWR Morb Mortal Wkly Rep. 2014;61(53):1-121.
  20. Aragon TJ, Vugia DJ, Shallow S, Samuel MC, Reingold A, Angulo FJ, Bradford WZ. Case-control study of shigellosis in San Francisco: the role of sexual transmission and HIV infection. Clin Infect Dis. 2007;44(3):327-34.
  21. Okame M, Adachi E, Sato H, Shimizu S, Kikuchi T, Miyazaki N, Koga M, Nakamura H, Suzuki M, Oyaizu N, Fujii T, Iwamoto A, Koibuchi T. Shigella sonnei outbreak among men who have sex with men in Tokyo. Jpn J Infect Dis. 2012;65(3):277-8.
  22. Watson, JT, Jones RC, Fernandez J, Cortes C, Gerber SI, Kuo KJ, Price JS, Brooks JT, Jennings D, Fair M, Mintz E, Bowen A. Shigella flexneri serotype 3 infections among men who have sex with men--Chicago, Illinois, 2003-2004. MMWR Morb Mortal Wkly Rep. 2005;54(33):820-2.
  23. Panel on Opportunistic Infections in HIV-Infected Adults and Adolescents. Guidelines for the prevention and treatment of opportunistic infections in HIV-infected adults and adolescents: recommendations from the Centers for Disease Control and Prevention, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America. US Department of Health and Human Services; [cited 2015 Mar 27]; Available from: http://aidsinfo.nih.gov/contentfiles/lvguidelines/adult_oi.pdf. [PDF - 407 pages]
  24. De Schrijver K, Bertrand S, Gutierrez Garitano I, Van den Branden D, Van Schaeren J. Outbreak of Shigella sonnei infections in the Orthodox Jewish community of Antwerp, Belgium, April to August 2008. Euro Surveill. 2011;16(14).
  25. Garrett V, Bornschlegel K, Lange D, Reddy V, Kornstein L, Kornblum J, Agasan A, Hoekstra M, Layton M, Sobel J. A recurring outbreak of Shigella sonnei among traditionally observant Jewish children in New York City: the risks of daycare and household transmission. Epidemiol Infect. 2006;134(6):1231-6.
  26. Sobel J, Cameron DN, Ismail J, Strockbine N, Williams M, Diaz PS, Westley B, Rittmann M, DiCristina J, Ragazzoni H, Tauxe RV, Mintz ED. A prolonged outbreak of Shigella sonnei infections in traditionally observant Jewish communities in North America caused by a molecularly distinct bacterial subtype. J Infect Dis. 1998;177(5):1405-9.
  27. Kantele A. As far as travelers' risk of acquiring resistant intestinal microbes is considered, no antibiotics (absorbable or nonabsorbable) are safe. Clin Infect Dis. 2015.
  28. O'Donnell AT, Vieira AR, Huang JY, Whichard J, Cole D, Karp BE. Quinolone-resistant Salmonella enterica serotype Enteritidis infections associated with international travel. Clin Infect Dis. 2014;59(9):e139-41.
  29. Crim SM, Iwamoto M, Huang JY, Griffin PM, Gilliss D, Cronquist AB, Cartter M, Tobin-D'Angelo M, Blythe D, Smith K, Lathrop S, Zansky S, Cieslak PR, Dunn J, Holt KG, Lance S, Tauxe R, Henao OL. Incidence and trends of infection with pathogens transmitted commonly through food--Foodborne Diseases Active Surveillance Network, 10 U.S. sites, 2006-2013. MMWR Morb Mortal Wkly Rep. 2014;63(15):328-32.
  30. CDC. National Enteric Disease Surveillance: Shigella Annual Report, 2012. [PDF - 9 pages] 2014.
  31. CDC. National Enteric Disease Surveillance: Shigella Annual Summary, 2008. [PDF - 3 pages] 2012.
  • Page last reviewed: April 2, 2015
  • Page last updated: April 2, 2015
  • Content source:
    • Centers for Disease Control and Prevention
      National Center for Emerging and Zoonotic Infectious Diseases (NCEZID)
      Division of Foodborne, Waterborne, and Environmental Diseases (DFWED)
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