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Since April, 277 persons infected with Salmonella Saintpaul with the same genetic fingerprint have been identified in 28 states and the District of Columbia: Arkansas (2 persons), Arizona (19), California (6), Colorado (1), Connecticut (2), Florida (1), Georgia (7), Idaho (3), Illinois (34), Indiana (7), Kansas (8), Kentucky (1), Maryland (1), Michigan (2), Missouri (4), New Mexico (68), New York (2), North Carolina (1), Ohio (3), Oklahoma (4), Oregon (3), Tennessee (4), Texas (68), Utah (2), Virginia (16), Vermont (1), Washington (1), Wisconsin (5), and the District of Columbia (1). These were identified because clinical laboratories in all states send Salmonella strains from ill persons to their State public health laboratory for characterization. Among the 202 persons with information available, illnesses began between April 10 and June 5, 2008. Patients range in age from <1 to 88 years; 46% are female. At least 43 persons were hospitalized. No deaths have been officially attributed to this outbreak. However, a man in his sixties who died in Texas from cancer had an infection with the outbreak strain of Salmonella Saintpaul at the time of his death. The infection may have contributed to his death.