Rabies Serology

In previous studies all healthy persons tested 2-4 weeks after completion of pre-exposure and postexposure rabies prophylaxis in accordance with ACIP guidelines demonstrated an adequate antibody response to rabies. Therefore, no testing of patients completing pre-exposure or postexposure prophylaxis is necessary to document seroconversion unless the person is immunosuppressed, significant deviations of the prophylaxis schedule occurs, or the patient initiated treatment internationally with a non-cell culture vaccine.

Rabies virus neutralization tests, such as the rapid fluorescent focus inhibition test (RFFIT), are currently the gold standard serology assay recommended by both the ACIP and WHO. While other serology tests, such as ELISA, may show promise and be appropriate for research, discrepant results between such tests and virus neutralization activity have been observed. Alternative assays not recommended by ACIP or WHO are not recommended for samples requiring clinical decision making.

RFFIT testing may be available in state through a state health department or University. The state or local health department may provide assistance with obtaining RFFIT testing in state if available. In addition, two commercial laboratories perform RFFIT testing for rabies.

Atlanta Health Associates
309 Pirckle Ferry Road, Suite D300
Cumming, GA 30040
Phone: 770-205-9091 or 800-717-5612
Fax: 770-204-9021
www.atlantahealth.net

Kansas State University
1800 Denison Avenue
Manhattan, KS 66506-5600
Phone: 785-532-4483
www.vet.ksu.edu/depts/dmp/service/rabies/index.htm