Family History and Genetic Risks
Genetic risk assessment should be based on family history, paternal age, and ethnicity. A three-generation family history of genetic disorders should be obtained, as certain disorders (sex-linked or autosomal recessive) can skip generations. A number of genetic disorders, such as cystic fibrosis, Klinefelter syndrome, Kartagener syndrome, and polycystic kidney disease, can impair fertility and sperm quality.
Past Medical and Surgical Histories
The provider should ask about the patient's past medical and surgical histories, including any ongoing medical conditions that might impair his reproductive health. Several medical conditions have been associated with reduced sperm quality and fertility issues, including obesity, diabetes mellitus, varicocele, sexually transmitted infections (STIs), and cancer treatments during childhood.
For further detail on the preconception clinical content for men, please read the full article.