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Emerging Infectious Diseases Journal
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Volume 5: No. 3, July 2008

ORIGINAL RESEARCH
National Trends and Disparities in the Incidence of Hepatocellular Carcinoma, 1998–2003

Men, by Race

Age, y Rate per 100,000
All races White Black Asian/Pacific Islander
20-24 0.1 0.1 0.2 0.4
25-29 0.2 0.1 0.4 1.1
30-34 0.3 0.2 0.7 2.1
35-39 0.8 0.4 1.5 5.3
40-44 2.3 1.8 3.8 8.5
45-49 7.5 6.1 14.0 18.9
50-54 11.0 8.9 23.0 27.1
55-59 12.3 10.0 23.5 37.2
60-64 15.1 12.5 22.6 56.0
65-69 20.6 18.0 26.1 71.1
70-74 24.1 21.6 31.8 75.2
75-79 27.0 25.2 27.6 80.0
80-84 23.2 21.7 24.7 70.6
≥85 17.9 16.6 19.7 57.9

Women, by Race

Age, y Rate per 100,000
All races White Black Asian/Pacific Islander
20-24 0.1 0.1 0.1 0.4
25-29 0.1 0.1 0.1 0.1
30-34 0.1 0.1 0.2 0.5
35-39 0.2 0.2 0.5 0.6
40-44 0.5 0.3 1.0 1.6
45-49 1.2 1.0 2.0 2.4
50-54 1.7 1.4 2.9 4.6
55-59 2.6 2.1 4.4 7.3
60-64 4.2 3.4 5.9 18.2
65-69 6.5 5.2 8.2 30.1
70-74 8.1 7.0 10.9 33.2
75-79 8.8 7.8 11.6 30.7
80-84 8.6 7.8 10.3 34.5
≥85 6.1 5.9 5.5 19.8

Men and Women, by Ethnicity

Age, y Rate per 100,000
Hispanic men Non-Hispanic men Hispanic women Non-Hispanic women
20-24 0.1 0.1 0 0.1
25-29 0.1 0.2 0.1 0.1
30-34 0.3 0.4 0.1 0.2
35-39 0.7 0.8 0.2 0.2
40-44 3.5 2.2 0.4 0.5
45-49 13.8 6.8 1.7 1.1
50-54 19.6 10.2 2.7 1.7
55-59 27.1 11.1 5.9 2.3
60-64 31.5 13.9 9.7 3.8
65-69 46.3 18.7 15.8 5.8
70-74 49.6 22.5 19.8 7.4
75-79 60.6 25.2 26.6 7.8
80-84 44.7 22.3 24.0 8.0
≥85 40.7 16.8 22.5 5.5

Figure 1. Age-Specific Incidence of Hepatocellular Carcinoma, by Patients’ Sex and Race/Ethnicity, United States, 1998–2003.
Data cover 83% of the U.S. population and are from population-based cancer registries that participate in the National Program of Cancer Registries (NPCR) and the Surveillance, Epidemiology, and End Results (SEER) Program and that met study criteria.

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Characteristic APC
Male Female
Race/Ethnicity
White 4.8a 4.5a
Black 6.0a 1.7
Asian/Pacific Islander 0.4 1.2
Hispanic 3.6a 1.8
Age, y
<45 -0.6 -1.6
45-59 9.0a 9.0a
60-74 3.6a 3.2a
≥75 2.6a 3.8a
Region
Midwest 3.6a 2.9
South 5.9a 5.2a
Northeast 6.2a 5.9a
West 3.3a 3.0
Race/Ethnicity (Among Those Aged 45-59 y)
White 10.4a 9.5a
Black 8.9a 12.3a
Asian/Pacific Islander -2.7 -0.3
Hispanic 8.8a 3.5

Figure 2. Annual Percentage Change (APC) in Incidence of Hepatocellular Carcinoma, United States, 1998–2003.
Data cover 83% of the U.S. population and are from population-based cancer registries that participate in the National Program of Cancer Registries (NPCR) and the Surveillance, Epidemiology, and End Results (SEER) Program and that met study criteria.
a P < .05 indicates that the APC is significantly greater than zero.

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The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention.


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