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Brucellosis (Brucella spp.)
2010 Case Definition
CSTE Position Statement Number: 09-ID-14
Clinical description
An illness characterized by acute or insidious onset of fever and one or more of the following: night sweats, arthralgia, headache, fatigue, anorexia, myalgia, weight loss, arthritis/spondylitis, meningitis, or focal organ involvement (endocarditis, orchitis/epididymitis, hepatomegaly, splenomegaly).
Laboratory criteria for diagnosis
Definitive
- Culture and identification of Brucella spp. from clinical specimens
- Evidence of a fourfold or greater rise in Brucella antibody titer between acute- and convalescent-phase serum specimens obtained greater than or equal to 2 weeks apart
Presumptive
- Brucella total antibody titer of greater than or equal to 160 by standard tube agglutination test (SAT) or Brucella microagglutination test (BMAT) in one or more serum specimens obtained after onset of symptoms
- Detection of Brucella DNA in a clinical specimen by PCR assay
Case classification
Probable: A clinically compatible illness with at least one of the following:
- Epidemiologically linked to a confirmed human or animal brucellosis case
- Presumptive laboratory evidence, but without definitive laboratory evidence, of Brucella infection
Confirmed: A clinically compatible illness with definitive laboratory evidence of Brucella infection
See also
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