Know Your Role


In eRA Commons

Select Approach

An applicant organization will determine how best to submit its application(s) to CDC via Applicant organizations can choose from one of these three options:

Obtain Software


In order to access, complete and submit grant applications, applicants need to download the PureEdge Viewer from

Creating PDFs

The Department of Health and Human Services and the Centers for Disease Control and Prevention (HHS/CDC) require all text attachments to the PureEdge forms to be submitted as PDF files.

PDF creation software is needed to create the PDF (the free Adobe Reader will NOT create an Adobe file). has published a list of some available tools and software to assist you

Note: Attachments generated from PureEdge forms, such as the R&R SubAward Budget Attachment Form, should not be converted to PDF.

Non-Windows (Macintosh, Linux, etc.)

If the applicant does not have a Windows operating system, the applicant can download and complete PureEdge forms by:

For details, go to the PureEdge Support for Non-Windows Users page (’s website)

Software FAQs


Prior to submitting a grant application online through to HHS/CDC, an applicant organization must complete a one-time registration both at and eRA Commons. Principal Investigators do not have to register at, but must register with Commons.

Registration Requirements for Electronic Submission

CCR 4 registration (requires DUNS #) Obtain and register credentials

Authorize Organization Rep. eRA Commons Registration (Org. registration requires DUNS #)
Principal Investigators 1, 2, 3       checked
Institutions/ Organizations checked checked checked checked

1 Principal Investigators (PI) must be affiliated with applicant organization
2 PIs and Authorized Organizational Representative (AOR)/Signing Officials (SO) need separate accounts in eRA Commons (even if the same person has both roles) because if an AOR/SO is given a PI’s role, it overrides the AOR/SO’s privileges such as the ability to reject an application, submit Just-In-Time information, etc.
3 Internet Assisted Review (IAR) registration is not enough. PIs must work through their institutions for full eRA Commons registration.
4 New organizations should allow extra time to obtain an Employer Identification Number (EIN)

Each registration is a multi-step process. Allow for 2-4 weeks to complete these registrations.

New businesses [i.e. those applying to the Internal Revenue Service (IRS) for an Employer Identification Number (EIN) to complete the CCR registration] should start the process at least two months (eight weeks) prior to the grant submission date.

eRA Commons Registration Registration

Registration FAQs

Important Tips

List of application checks (Generic Validations)

eRA Commons checks each application against a series of policy guidelines. Here is a summary listing of those generic validations