Rapid Identification of Nocardia farcinica by a PCR Assay

The bacterial complex Nocardia asteroides is a serious threat to immunosuppressed individuals, especially those with organ transplants, lung disease, and AIDS.  Nocardia farcinica is the most clinically significant species because it characteristically demonstrates resistance to multiple, extended spectrum antimicrobial agents.  Traditional identification methods are time consuming and labor-intensive (up to 8 weeks for definitive results).  This invention comprises a unique DNA sequence within the N. farcinica genome which allows for PCR-based diagnostics which are specific to the species and do not cross react with closely related species and genera

Inventors: Brent A Lasker, June M Brown, Kim T Pham

CDC Reference Number: I-027-00/0

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