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Oligonucelotide Sequences for Amplification of Streptococcus pneumoniae Gene psaA from the 90 Serotypes Using the Polymerase Chain Reaction Assay. Disease caused by Streptococcus pneumoniae (pneumococcus) is an important cause of morbidity and mortality in the United States and developing countries. Pneumococcal disease is very prevalent among the very young, the elderly, and immunocompromised persons. The present invention relates to diagnostic assays and kits for detecting the presence of S. pneumoniae in a sample and to vaccines for use against S. pneumoniae. More specifically, the present invention relates to PCR assays for the presence of S. pneumoniae surface adhesion A protein (PsaA) and to vaccines raised against a portion of PsaA encoded by a PCR product that is provided using specific primers. Inventors: Jacqueline Sampson, Katherine E Morrison, Jennifer Crook, Edwin W Ades, and George Carlone CDC Reference Number: I-013-99/0 USPTO Serial Number: PCT/US99/13421 Patent Number: | ||||||||||||||||
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