Histoplasmosis is a mycotic infection of varying severity, usually localized in the lungs. Caused by Histoplasma capsalatum, infections are usually asymptomatic but can develop into chronic disease, especially in immune compromised individuals. The present invention relates to reagents and methods for the detection of histoplasmosis. In particular, the present invention relates to nucleic acids (DNAs) relating to the M antigen gene of H. capsulatum; to vectors and host expression systems containing these nucleic acids; to nucleic acids (RNAs) which encode the M antigen of H. capsulatum; to isolated and recombinantly-produced antigens encoded by these nucleic acids; to antibodies produced against these antigens; to methods and kits for detecting histoplasmosis using these nucleic acids, antigens and antibodies; and to vaccines for the treatment of prevention histoplasmosis.   

Inventors: Rosely Zancope-Oliveira, Timothy J Lott, Leonard W Mayer, Errol Reiss, and George S Deepe

CDC Reference Number: I-002-97/0

USPTO Serial Number: 09/674,195

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