Tuberculosis is a mycobacterial disease which is a major cause of disability and death in the developing world and immunocompromised patients. This invention includes an isolated nucleic acid encoding a SecA protein of Mycobacteria tuberculosis and provides methods of screening for putative M. tuberculosis virulence factors translocated by the SecA protein. These may further provide for useful vaccines and diagnostic tests for active tuberculosis.  

Inventors: Fred D Quinn, Marie Owens, Harold King, and Michael Schmidt

CDC Reference Number: E-066-95/1

USPTO Serial Number: 

Patent Number: 5,885,828