Table 1.5.a. Plasma methylmalonic acid: Total population

Geometric mean and selected percentiles of plasma concentrations (in µmol/L) for the total U.S. population aged 3 years and older, National Health and Nutrition Examination Survey, 1999–2002.

Geometric mean
(95% conf. interval)

Selected percentiles (95% conf. interval)

Sample
size

5th

50th

95th

Males and Females

Total, 3 years and older

.131

(.129-.134)

.070

(.060-.070)

.120

(.120-.130)

.290

(.280-.300)

16048

3–5 years

.120

(.116-.124)

.060

(.060-.070)

.120

(.110-.120)

.230

(.200-.250)

829

6–11 years

.121

(.117-.125)

.070

(.060-.070)

.120

(.110-.120)

.210

(.190-.220)

1929

12–19 years

.116

(.113-.120)

.050

(.050-.060)

.110

(.100-.110)

.230

(.210-.240)

4352

20–39 years

.122

(.119-.125)

.060

(.060-.070)

.110

(.110-.120)

.260

(.240-.270)

3189

40–59 years

.132

(.129-.134)

.060

(.060-.070)

.120

(.120-.130)

.250

(.240-.270)

2701

60 years and older

.171

(.166-.176)

.080

(.070-.080)

.160

(.150-.160)

.450

(.410-.530)

3048

Males

Total, 3 years and older

.135

(.132-.138)

.070

(.060-.070)

.130

(.120-.130)

.280

(.270-.300)

7799

3–5 years

.123

(.118-.129)

.060

(.060-.070)

.110

(.110-.120)

.230

(.200-.280)

432

6–11 years

.125

(.120-.130)

.060

(.060-.070)

.110

(.110-.120)

.200

(.180-.220)

986

12–19 years

.122

(.118-.126)

.070

(.060-.070)

.120

(.110-.120)

.230

(.220-.270)

2175

20–39 years

.128

(.123-.132)

.060

(.060-.070)

.130

(.120-.130)

.250

(.230-.290)

1355

40–59 years

.136

(.132-.140)

.080

(.070-.080)

.130

(.120-.130)

.270

(.240-.300)

1343

60 years and older

.173

(.168-.178)

.070

(.070-.080)

.160

(.150-.160)

.450

(.420-.500)

1508

Females

Total, 3 years and older

.128

(.126-.131)

.070

(.060-.070)

.110

(.110-.120)

.280

(.260-.280)

8249

3–5 years

.116

(.111-.122)

.060

(.060-.070)

.110

(.110-.120)

.200

(.180-.250)

397

6–11 years

.117

(.112-.123)

.070

(.060-.070)

.110

(.110-.120)

.190

(.180-.200)

943

12–19 years

.111

(.107-.116)

.050

(.050-.060)

.100

(.100-.110)

.220

(.200-.260)

2177

20–39 years

.117

(.114-.120)

.050

(.050-.060)

.100

(.100-.110)

.260

(.230-.270)

1834

40–59 years

.127

(.124-.131)

.060

(.060-.070)

.110

(.110-.120)

.250

(.230-.300)

1358

60 years and older

.170

(.164-.177)

.070

(.070-.080)

.150

(.140-.150)

.460

(.380-.570)

1540

Table 1.5.b. Plasma methylmalonic acid: Mexican Americans

Geometric mean and selected percentiles of plasma concentrations (in µmol/L) for Mexican Americans in the U.S. population aged 3 years and older, National Health and Nutrition Examination Survey, 1999–2002.

Geometric mean
(95% conf. interval)

Selected percentiles (95% conf. interval)

Sample
size

5th

50th

95th

Males and Females

Total, 3 years and older

.111

(.108-.113)

.050

(.050-.060)

.110

(.100-.110)

.220

(.220-.240)

4726

3–5 years

.108

(.103-.112)

.070

(.060-.070)

.110

(.100-.110)

.180

(.170-.210)

271

6–11 years

.104

(.100-.109)

.060

(<LOD-.060)

.100

(.090-.100)

.180

(.160-.190)

656

12–19 years

.104

(.102-.107)

.060

(.050-.060)

.100

(.090-.100)

.190

(.180-.220)

1644

20–39 years

.108

(.103-.113)

.050

(<LOD-.060)

.100

(.090-.100)

.230

(.210-.270)

870

40–59 years

.116

(.112-.120)

.060

(.050-.060)

.110

(.100-.110)

.230

(.220-.270)

634

60 years and older

.150

(.145-.155)

.060

(.060-.080)

.130

(.120-.130)

.440

(.400-.530)

651

Males

Total, 3 years and older

.117

(.114-.121)

.060

(<LOD-.060)

.100

(.100-.110)

.250

(.230-.280)

2305

3–5 years

.108

(.102-.115)

.060†

(.050-.080)

.100

(.100-.110)

.180†

(.160-.210)

142

6–11 years

.104

(.099-.109)

.050

(<LOD-.070)

.110

(.100-.110)

.170

(.150-.200)

339

12–19 years

.111

(.107-.115)

.050

(<LOD-.060)

.110

(.100-.110)

.210

(.190-.230)

814

20–39 years

.118

(.112-.125)

.060

(<LOD-.060)

.110

(.100-.110)

.280

(.230-.390)

385

40–59 years

.125

(.119-.132)

.070

(.060-.070)

.110

(.110-.120)

.260

(.220-.350)

301

60 years and older

.151

(.141-.162)

.070

(.060-.080)

.140

(.130-.150)

.500

(.330-.630)

324

Females

Total, 3 years and older

.104

(.102-.106)

.050

(.050-.060)

.095

(.090-.100)

.210

(.190-.220)

2421

3–5 years

.107

(.100-.114)

.060†

(<LOD-.070)

.110

(.100-.120)

.170†

(.160-.210)

129

6–11 years

.105

(.100-.111)

.070

(.060-.070)

.100

(.090-.100)

.170

(.150-.200)

317

12–19 years

.097

(.095-.100)

.060

(.050-.060)

.100

(.090-.100)

.170

(.170-.200)

830

20–39 years

.097

(.093-.103)

< LOD

.100

(.090-.100)

.170

(.160-.210)

485

40–59 years

.107

(.102-.112)

.060

(.050-.060)

.090

(.090-.100)

.190

(.180-.220)

333

60 years and older

.148

(.140-.157)

.070

(<LOD-.080)

.120

(.120-.130)

.430

(.380-.560)

327

< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.

† Estimate is subject to greater uncertainty due to small cell size.

Table 1.5.c. Plasma methylmalonic acid: Non-Hispanic blacks

Geometric mean and selected percentiles of plasma concentrations (in µmol/L) for non-Hispanic blacks in the U.S. population aged 3 years and older, National Health and Nutrition Examination Survey, 1999–2002.

Geometric mean
(95% conf. interval)

Selected percentiles (95% conf. interval)

Sample
size

5th

50th

95th

Males and Females

Total, 3 years and older

.110

(.107-.114)

.050

(.050-.060)

.100

(.100-.110)

.220

(.210-.240)

3768

3–5 years

.102

(.097-.107)

.060

(<LOD-.060)

.090

(.090-.100)

.170

(.160-.200)

245

6–11 years

.103

(.099-.107)

.070

(.060-.070)

.100

(.090-.100)

.170

(.150-.190)

619

12–19 years

.101

(.097-.105)

.050

(.050-.060)

.100

(.090-.100)

.180

(.180-.200)

1264

20–39 years

.101

(.097-.106)

.060

(.050-.060)

.100

(.090-.100)

.180

(.160-.220)

596

40–59 years

.115

(.109-.122)

.060

(<LOD-.060)

.110

(.100-.110)

.230

(.190-.270)

551

60 years and older

.156

(.148-.165)

.070

(.070-.080)

.140

(.130-.140)

.400

(.310-.500)

493

Males

Total, 3 years and older

.115

(.111-.119)

.050

(.050-.060)

.100

(.100-.110)

.230

(.220-.260)

1846

3–5 years

.103

(.096-.110)

.060†

(<LOD-.060)

.090

(.090-.110)

.180†

(.150-.230)

127

6–11 years

.104

(.100-.109)

.060

(<LOD-.060)

.100

(.090-.100)

.160

(.150-.190)

312

12–19 years

.107

(.102-.112)

.060

(<LOD-.060)

.100

(.090-.100)

.190

(.180-.240)

645

20–39 years

.110

(.103-.119)

.060

(<LOD-.070)

.100

(.100-.110)

.220

(.170-.260)

248

40–59 years

.119

(.111-.128)

< LOD

.120

(.110-.120)

.250

(.200-.290)

277

60 years and older

.155

(.143-.167)

.070

(.050-.070)

.140

(.120-.150)

.450

(.310-.560)

237

Females

Total, 3 years and older

.107

(.104-.110)

.050

(.050-.060)

.090

(.090-.100)

.220

(.200-.230)

1922

3–5 years

.101

(.094-.109)

.050†

(<LOD-.070)

.100

(.090-.100)

.150†

(.130-.190)

118

6–11 years

.102

(.097-.107)

.060

(.060-.070)

.100

(.090-.100)

.170

(.150-.200)

307

12–19 years

.095

(.090-.100)

< LOD

.080

(.080-.090)

.170

(.160-.180)

619

20–39 years

.095

(.092-.099)

.060

(.050-.060)

.080

(.080-.090)

.160

(.140-.180)

348

40–59 years

.112

(.104-.121)

.050

(<LOD-.070)

.110

(.100-.110)

.210

(.170-.230)

274

60 years and older

.157

(.147-.168)

.080

(.070-.080)

.140

(.120-.140)

.390

(.270-.620)

256

< LOD means less than the limit of detection, which may vary for some compounds by year. See Appendix D for LOD.

† Estimate is subject to greater uncertainty due to small cell size.

Table 1.5.d. Plasma methylmalonic acid: Non-Hispanic whites

Geometric mean and selected percentiles of plasma concentrations (in µmol/L) for non-Hispanic whites in the U.S. population aged 3 years and older, National Health and Nutrition Examination Survey, 1999–2002.

Geometric mean
(95% conf. interval)

Selected percentiles (95% conf. interval)

Sample
size

5th

50th

95th

Males and Females

Total, 3 years and older

.139

(.136-.142)

.080

(.070-.080)

.130

(.120-.130)

.290

(.280-.300)

6178

3–5 years

.129

(.123-.136)

.080

(.070-.080)

.120

(.110-.120)

.240

(.210-.270)

229

6–11 years

.130

(.124-.137)

.070

(.070-.080)

.130

(.110-.130)

.230

(.200-.270)

495

12–19 years

.124

(.120-.128)

.070

(.060-.070)

.110

(.110-.120)

.230

(.220-.280)

1073

20–39 years

.130

(.126-.133)

.070

(.060-.070)

.120

(.120-.130)

.250

(.230-.270)

1380

40–59 years

.136

(.132-.139)

.070

(.070-.080)

.130

(.120-.130)

.250

(.240-.280)

1285

60 years and older

.174

(.168-.179)

.090

(.080-.090)

.160

(.150-.160)

.450

(.380-.530)

1716

Males

Total, 3 years and older

.141

(.138-.145)

.080

(.070-.080)

.140

(.130-.140)

.280

(.270-.300)

3021

3–5 years

.136

(.127-.146)

.080†

(.050-.080)

.130

(.120-.140)

.250†

(.210-.340)

120

6–11 years

.134

(.126-.143)

.080

(.060-.080)

.120

(.110-.130)

.240

(.200-.310)

264

12–19 years

.129

(.124-.134)

.060

(.060-.070)

.110

(.110-.120)

.240

(.220-.280)

533

20–39 years

.132

(.127-.138)

.060

(.060-.070)

.130

(.120-.130)

.250

(.230-.290)

576

40–59 years

.139

(.134-.144)

.070

(.070-.080)

.120

(.120-.130)

.270

(.240-.300)

667

60 years and older

.174

(.168-.180)

.090

(.080-.100)

.170

(.160-.170)

.440

(.380-.490)

861

Females

Total, 3 years and older

.137

(.134-.140)

.080

(.070-.080)

.120

(.120-.130)

.290

(.280-.310)

3157

3–5 years

.122

(.113-.132)

.070†

(.070-.090)

.120

(.110-.120)

.200†

(.160-.250)

109

6–11 years

.125

(.117-.134)

.070

(.060-.080)

.110

(.110-.130)

.210

(.180-.270)

231

12–19 years

.119

(.114-.125)

.070

(.060-.070)

.100

(.100-.110)

.230

(.200-.300)

540

20–39 years

.127

(.123-.131)

.060

(.060-.070)

.110

(.110-.120)

.260

(.250-.280)

804

40–59 years

.132

(.128-.137)

.080

(.070-.080)

.130

(.120-.130)

.250

(.220-.300)

618

60 years and older

.173

(.166-.181)

.090

(.080-.090)

.160

(.150-.160)

.450

(.370-.570)

855

† Estimate is subject to greater uncertainty due to small cell size.