RTECS:ZF0800000 The Registry of Toxic Effects of Chemical Substances | CDC/NIOSH

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Xylitol

RTECS #: ZF0800000

CAS #: 87-99-0

UPDATE: June 1998 MW: 152.17 MF: C₅H₁₂O₅

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

ACUTE TOXICITY DATA:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

Eutrit

Kannit

Klinit

Newtol

Xylite

Xylite (sugar)

Xyliton

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intramuscular
mouse lethal dose (50 percent kill): 10,200 mg/kg N/R NIIRDN -,297,1990
intramuscular
rat lethal dose (50 percent kill): 15 gm/kg N/R NIIRDN -,297,1990
intraperitoneal
mouse lowest published lethal dose: 22,100 mg/kg N/R RPTOAN 34,124,1971
intravenous
mouse lethal dose (50 percent kill): 8,500 mg/kg N/R NIIRDN -,352,1995
intravenous
rat lethal dose (50 percent kill): 10,800 mg/kg N/R NIIRDN -,297,1990
intravenous
rabbit lethal dose (50 percent kill): 4 gm/kg Biochemical: Metabolism (intermediary): Other FEPRA7 31,726,1972
oral
mouse lethal dose (50 percent kill): 12,500 mg/kg Behavioral: General anesthetic

Gastrointestinal: Ulceration or bleeding from stomach

Liver: Other changes GISAAA 36(2),25,1971
oral
rat lethal dose (50 percent kill): 16,500 mg/kg N/R NIIRDN -,297,1990
oral
rabbit lethal dose (50 percent kill): 25 gm/kg Behavioral: General anesthetic

Gastrointestinal: Ulceration or bleeding from stomach

Liver: Other changes GISAAA 36(2),25,1971
subcutaneous
mouse lethal dose (50 percent kill): 18,300 mg/kg N/R NIIRDN -,297,1990
subcutaneous
rat lethal dose (50 percent kill): >25 gm/kg N/R NIIRDN -,297,1990

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X2606;
Number of Industries 1;
Total Number of Facilities 53;
Number of Occupations 3;
Total Number of Employees Exposed 984;
Total Number of Female Employees Exposed 796

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: Body fluid assay; Host-mediated assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY

REFERENCES:
CODEN
REFERENCE

FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967-

Used for treatment of metabolic diseases such as ketosis in diary cattle

RTECS Compound Description:
Mutagen

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