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Vanadium pentoxide

RTECS #: YW2125000

CAS #: 1314-62-1

UPDATE: May 2009 MW: 181.88 MF: O5V2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. TUMORIGENIC DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. REFERENCES:

SYNONYMS:

  1. Vanadium (V) oxide


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
multiple
mouse 		lowest published toxic dose: 1 mg/m3/2 year- continuous Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		TOXID9 72,85,2003


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
human 		lowest published toxic concentration: 1 mg/m3/8 hour Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Sputum

Nutritional and Gross Metabolic: Body temperature increase 		VCVN5* -,130,1993
inhalation
rat 		lowest published toxic concentration: 0.6 mg/m3 Behavioral: Muscle weakness

Musculoskeletal: Other changes 		HBTME* -,905,2007
intratracheal
mouse 		lowest published toxic dose: 6.3 mg/kg Lung, Thorax, or Respiration: Respiratory depression

Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation 		TOXID9 66,194,2002
intratracheal
rat 		lowest published toxic dose: 6.3 mg/kg Lung, Thorax, or Respiration: Respiratory depression TOXID9 66,194,2002
intravenous
human 		lowest published toxic dose: 1.43 mg/kg Cardiac: Pulse rate decreased with fall in BP

Gastrointestinal: Nausea or vomiting

Kidney, Ureter, and Bladder: Proteinuria 		HBTME* -,905,2007
intravenous
rabbit 		lethal dose (50 percent kill): 1 mg/kg N/R VCVN5* -,126,1993
oral
mouse 		lethal dose (50 percent kill): 23.4 mg/kg Cardiac: Other changes

Behavioral: Alteration of classical conditioning

Lung, Thorax, or Respiration: Acute pulmonary edema 		VCVN5* -,126,1993
subcutaneous
guinea pig 		lethal dose (50 percent kill): 20 mg/kg N/R VCVN5* -,126,1993
subcutaneous
mouse 		lethal dose (50 percent kill): 85.7 mg/kg N/R VCVN5* -,126,1993


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 2 mg/m3/12 day- intermittent Lung, Thorax, or Respiration: Changes in lung weight TOSCF2 77,6,2004
inhalation
mouse 		lowest published toxic concentration: 3.6 mg/m3/1 week- intermittent Brain and Coverings: Other degenerative changes TOXID9 44,124,2005
inhalation
mouse 		lowest published toxic concentration: 3,638 gm/m3/12 week- intermittent Blood: Changes in spleen TOXID9 44,236,2005
inhalation
mouse 		lowest published toxic concentration: 1.82 mg/m3/4 week- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		TOXID9 66,34,2002
inhalation
rat 		lowest published toxic concentration: 1 mg/m3/12 day- intermittent Lung, Thorax, or Respiration: Changes in lung weight TOSCF2 77,6,2004
intratracheal
rat 		lowest published toxic dose: 1,600 µg/kg/2 day- intermittent Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation 		TOXID9 60,196,2001
intratracheal
rat 		lowest published toxic dose: 6.72 mg/kg/48 week- intermittent Endocrine: Hypoglycemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport 		HBTME* -,905,2007
multiple
mouse 		lowest published toxic concentration: 1 mg/m3/90 day- continuous Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Lung, Thorax, or Respiration: Changes in lung weight 		TOXID9 72,85,2003
multiple
mouse 		lowest published toxic concentration: 1 mg/m3/2 year- continuous Lung, Thorax, or Respiration: Fibrosing alveolitis TOXID9 72,85,2003
multiple
rat 		lowest published toxic concentration: 1 mg/m3/90 day- continuous Lung, Thorax, or Respiration: Fibrosing alveolitis

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Lung, Thorax, or Respiration: Changes in lung weight 		TOXID9 72,85,2003
oral
rat 		lowest published toxic dose: 4 mg(V)/kg/80 day- intermittent Behavioral: Alteration of classical conditioning HBTME* -,905,2007


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.05 mg(V2O5)/m3 (resp. dust, fume) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
MUREAV 659,248,2008
TOXICOLOGY REVIEW
MUREAV 659,248,2008
TOXICOLOGY REVIEW
HBTME* ,905,2007
TOXICOLOGY REVIEW
MUREAV 566,49,2004
TOXICOLOGY REVIEW
MUREAV 681,3,2009


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.05 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.05 mg/m3 (resp. dust, fume), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.03 mg(V)/m3 (dust, fume), OCT 2002
Occupational Exposure Limit - FRANCE VME 0.05 mg/m3 (dust, fume), FEB2006
Occupational Exposure Limit - HUNGARY time-weighted average 0.05 mg/m3 (resp), short term exposure limit 0.2 mg/m3 (resp), SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.05 mg/m3, APR2007
Occupational Exposure Limit - KOREA time-weighted average 0.05 mg/m3, 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.5 mg/m3 (respirable, fume), 2004
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.05 mg/m3 (respirable dust and fume), JAN2002
Occupational Exposure Limit - SWEDEN time-weighted average 0.2 mg(V)/m3 (total dust);
ceiling concentration 0.05 mg(V)/m3 (resp. dust), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.05 mg/m3,KZG- week 0.05 mg/m3, DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.05 mg/m3, 2005


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
HBTME*
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.

RTECS Compound Description:
   Human Data

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