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Urea, 1,1 - dimethyl - 3 - (alpha,alpha,alpha - trifluoro - m - tolyl) -

RTECS #: YT1575000

CAS #: 2164-17-2

UPDATE: February 2009 MW: 232.23 MF: C10H11F3N2O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1,1 - Dimethyl - 3 - (3 - trifluoromethylphenyl) urea
  2. 1,1 - Dimethyl - 3 - (alpha,alpha,alpha - trifluoro - m - tolyl) urea
  3. 3 - (5 - Trifluormethylphenyl) - 1,1 - dimethylharnstoff (German)
  4. 3 - (m - Trifluoromethylphenyl) - 1,1 - dimethylurea
  5. C 2059
  6. Ciba 2059
  7. Cotoran
  8. Cotoran multi 50WP
  9. Cottonex
  1. Fluometuron
  2. Herbicide C - 2059
  3. Higalcoton
  4. Lanex
  5. N - (3 - Trifluoromethylphenyl) - N' - N' - dimethylurea
  6. N - (m - Trifluoromethylphenyl) - N',N' - dimethylurea
  7. NCI - C08695
  8. Pakhtaran
  9. Urea, N,N - dimethyl - N' - (3 - (trifluoromethyl) phenyl) -


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA inhibition oral
mouse 		1 gm/kg MUREAV 58,353,1978
mutation in microorganisms Salmonella typhimurium 1 µg/plate (-enzymatic activation step) MUREAV 58,353,1978
morphological transform rat embryo 56 µg/plate JJATDK 1,190,1981


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 87 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Blood: Leukemia 		NCITR* NCI-TR-195,1980
oral
rat 		lowest published toxic dose: 75 mg/kg/75 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria EXONC* 14,36,1992


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 552 mg/kg N/R PESTD5 17,351,1976
intraperitoneal
rat 		lethal dose (50 percent kill): 685 mg/kg N/R PESTD5 17,351,1976
oral
dog 		lethal dose (50 percent kill): >10 gm/kg N/R CIGET* -,-,1977
oral
guinea pig 		lethal dose (50 percent kill): 810 mg/kg N/R 85GMAT -,116,1982
oral
mouse 		lethal dose (50 percent kill): 900 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory stimulation 		CIGET* -,-,1977
oral
rat 		lethal dose (50 percent kill): 1,450 mg/kg N/R FATOAO 35,352,1972
oral
rabbit 		lethal dose (50 percent kill): 2,500 mg/kg N/R 85GMAT -,116,1982
skin
rat 		lethal dose (50 percent kill): >2 gm/kg N/R PEMNDP 9,410,1991
skin
rabbit 		lethal dose (50 percent kill): >10 gm/kg N/R WRPCA2 9,119,1970
unreported route
mouse 		lethal dose (50 percent kill): 850 mg/kg N/R 30ZDA9 -,233,1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 5,320 µg/m3/24 hour/13 week- continuous Blood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases 		GISAAA 51(8),80,1986
oral
rat 		lowest published toxic dose: 9 gm/kg/90 day- continuous Endocrine: Changes in spleen weight

Blood: Changes in spleen

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** PB80-217904
oral
rat 		lowest published toxic dose: 34,524 mg/kg/12 week- intermittent Blood: Normocytic anemia

Blood: Changes in other cell count (unspecified)

Blood: Changes in erythrocyte (RBC) count 		EVMJB9 40,107,1980


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 30,245,1983
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 30,245,1983
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,56,1987
TOXICOLOGY REVIEW
ENTOX* -,340,2005
TOXICOLOGY REVIEW
FEREAC 73,29456,2008


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,121,1998
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X1526;
Number of Industries 1;
Total Number of Facilities 31;
Number of Occupations 4;
Total Number of Employees Exposed 644;
Total Number of Female Employees Exposed 123


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a herbicide
On EPA IRIS database
NCI Carcinogenesis Bioassay (feed);equivocal evidence:mouse NCITR* NCI-TR-195,1980
NCI Carcinogenesis Bioassay (feed);no evidence:rat NCITR* NCI-TR-195,1980


REFERENCES:

CODEN
REFERENCE
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
CIGET* Ciba-Geigy Toxicology Data/Indexes. (Ciba-Geigy Corp., 556 Morris Ave., Summit, NJ 07901)
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
EVMJB9 Journal of the Egyptian Veterinary Medical Association. (Egyptian Veterinary Medical Association, 8, 26 July St., Cairo, Egypt) V.27- 1967-
EXONC* Experimental Oncology (Journal of ucrainian section of European institute of ecology and cancer, Kiev-22, Vaselkovskaya str., 25, Kiev-22) V.1- 1979-
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
PESTD5 Proceedings of the European Society of Toxicology. (Amsterdam, Netherlands) V.16-18, 1975-77. Discontinued.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued.

Used as a herbicide

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen

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