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Urea, N - (1,3 - bis (hydroxymethyl) - 2,5 - dioxo - 4 - imidazolidinyl) - N,N' - bis (hydroxymethyl) -

RTECS #: YS2717000

CAS #: 78491-02-8

UPDATE: November 2005 MW: 278.26 MF: C8H14N4O7


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Diazolidinyl urea
  2. Germall 11
  3. Imidazolidinyl urea 11
  1. N - (1,3 - Bis (hydroxymethyl) - 2,5 - dioxo - 4 - imidazolidinyl) - N,N' - bis (hydroxymethyl) urea
  2. N - (Hydroxymethyl) - N - (1,3 - dihydroxymethyl - 2,5 - dioxo - 4 - imidazolidinyl) - N' - (hydroxymethyl) urea


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 0.36 mg/L/20 minute (+/-enzymatic activation step) MUREAV 514,133,2002
micronucleus test hamster fibroblast 25 µmol/L/3 hour (-enzymatic activation step) MUREAV 514,133,2002
micronucleus test hamster fibroblast 100 µmol/L/3 hour (+enzymatic activation step) MUREAV 514,133,2002
micronucleus test hamster fibroblast 2 mmol/L/15 minute MUREAV 514,133,2002


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
wild bird 		lethal dose (50 percent kill): >2,250 mg/kg N/R JTOTDO 14,3,1995
oral
mouse 		lethal dose (50 percent kill): 3,573 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Ataxia

Gastrointestinal: Changes in structure or function of salivary glands 		JTOTDO 14,3,1995
oral
rat 		lethal dose (50 percent kill): 2,600 mg/kg N/R JACTDZ 9(2),229,1990
skin
rabbit 		lethal dose (50 percent kill): >2 gm/kg Skin: After systemic exposure: Dermatitis, other JTOTDO 14,3,1995


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 11,200 mg/kg/7 day- intermittent Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		JACTDZ 9(2),229,1990
oral
rat 		lowest published toxic dose: 26,100 mg/kg/29 day- intermittent Gastrointestinal: Gastritis

Endocrine: Changes in adrenal weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		JACTDZ 9(2),229,1990
skin
human 		lowest published toxic concentration: 1 pph/48 hour- continuous Skin: After topical application: Dermatitis, allergic AJCDE* 13,177,2002


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X2520;
Number of Industries 2;
Total Number of Facilities 429;
Number of Occupations 3;
Total Number of Employees Exposed 6,467;
Total Number of Female Employees Exposed 6,039


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
AJCDE* American Journal of Contact Dermatitis: Official Journal of the American Contact Dermatitis Society (Philadelphia, PA : W.B. Saunders, Harcourt Brace Jovanovich) V.1-14 1990-2003.
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
JTOTDO Journal of Toxicology, Cutaneous and Ocular Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1982-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-

Used as a preservative

RTECS Compound Description:
   Mutagen
   Human Data

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