The Registry of Toxic Effects of Chemical Substances

Uracil, 6 - propyl - 2 - thio -

RTECS #: YR1400000

CAS #: 51-52-5

UPDATE: May 2008 MW: 170.25 MF: C7H10N2OS


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 2,3 - Dihydro - 6 - propyl - 2 - thioxo - 4 (1H) - pyrimidinone
  2. 2 - Mercapto - 4 - hydroxy - 6 - n - propylpyrimidine
  3. 2 - Mercapto - 6 - propyl - 4 - pyrimidone
  4. 2 - Mercapto - 6 - propylpyrimid - 4 - one
  5. 2 - Thio - 4 - oxo - 6 - propyl - 1,3 - pyrimidine
  6. 2 - Thio - 6 - propyl - 1,3 - pyrimidin - 4 - one
  7. 4 (1H) - Pyrimidinone, 2,3 - dihydro - 6 - propyl - 2 - thioxo -
  8. 4 - Propyl - 2 - thiouracil
  9. 6 - Propil - tiouracile (Italian)
  10. 6 - Propyl - 2 - thio - 2,4 (1H,3H) pyrimidinedione
  11. 6 - Propylthiouracil
  12. 6 - Propyl - 2 - thiouracil
  13. 6 - Thio - 4 - propyluracil
  14. 6 - n - Propylthiouracil
  15. 6 - n - Propyl - 2 - thiouracil
  16. PTU (thyreostatic)
  1. Procasil
  2. Propacil
  3. Propilthiouracil
  4. Propycil
  5. Propyl - thiorist
  6. Propyl - thiorit
  7. Propyl - thyracil
  8. Propylthiouracil
  9. Propythiouracil
  10. Prothiucil
  11. Prothiurone
  12. Prothycil
  13. Prothyran
  14. Protiural
  15. Thiuragyl
  16. Thyreostat II


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA damage human other cell types 1.8 mmol/L/20 hour TXAPA9 203,99,2005
DNA inhibition human lymphocyte 100 mg/L JCEMAZ 43,1406,1976
mutation in microorganisms Saccharomyes cerevisiae 1 gm/L (-enzymatic activation step) CHINAG (21),847,1980


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
guinea pig 		lowest published toxic dose: 1,470 mg/kg (38-58 day pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Specific developmental abnormalities: Endocrine system 		ANREAK 115,359,1953
oral
rat 		lowest published toxic dose: 4,600 mg/kg (70 day prior to copulation/1-22 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Effects on newborn: Stillbirth

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) 		PIAIA9 69,624,1962
oral
rat 		lowest published toxic dose: 400 mg/kg (20-21 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Endocrine system 		ANREAK 198,637,1980
oral
rat 		lowest published toxic dose: 240 mg/kg (10-21 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Behavioral 		NETEEC 11,251,1989
oral
rat 		lowest published toxic dose: 500 mg/kg (18-22 day pregnant/20 day after birth) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Physical 		JOENAK 62,213,1974
oral
rat 		lowest published toxic dose: 1,050 mg/kg (21 day after birth) Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		PIAIA9 69,624,1962
oral
rat 		lowest published toxic dose: 10 mL/kg (25 day after birth) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Other effects on male

Endocrine: Evidence of thyroid hyperfunction 		JRPFA4 100,85,1994
oral
rat 		lowest published toxic dose: 19 mg/kg (6 day pregnant/21 day after birth) Reproductive: Specific developmental abnormalities: Endocrine system TOXID9 15,243,1995
oral
rat 		lowest published toxic dose: 2.8 mg/kg (16-22 day pregnant/21 day after birth) Reproductive: Specific developmental abnormalities: Endocrine system TOXID9 15,243,1995
oral
rat 		lowest published toxic dose: 14 mg/kg (16-22 day pregnant/21 day after birth) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Effects on newborn: Behavioral 		TOXID9 15,243,1995
oral
rat 		lowest published toxic dose: 18 mg/kg (7-22 day pregnant/21 day after birth) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Endocrine system 		ETOPFR 9,103,2001
oral
rat 		lowest published toxic dose: 11.28 mg/kg (6 day pregnant-30 day after birth) Reproductive: Specific developmental abnormalities: Central nervous system TOXID9 72,123,2003
oral
rat 		lowest published toxic dose: 9.12 mg/kg (6 day pregnant-21 day after birth) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Other developmental abnormalities 		TOXID9 72,123,2003
oral
rat 		lowest published toxic dose: 14.1 gm/kg (7-21 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Effects on newborn: Behavioral 		REPTED 17,475,2003
oral
rat 		lowest published toxic dose: 10 mg/kg (18 day pregnant-21 day after birth) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Effects on newborn: Behavioral 		TOXID9 44,200,2005
oral
rat 		lowest published toxic dose: 25 mg/kg (18 day pregnant-21 day after birth) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Physical 		TOXID9 44,200,2005
oral
rat 		lowest published toxic dose: 11.1 mg/kg (6 day pregnant -21 day after birth) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system 		TOXID9 44,201,2005
oral
rat 		lowest published toxic dose: 13.6 mg/kg (7-22 day pregnant/18 day after birth) Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Effects on newborn: Behavioral 		ARTODN 79,414,2005
oral
rat 		lowest published toxic dose: 39 mg/kg (18 day pregnant-21 day after birth) Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Delayed effects 		TOXID9 60,372,2001
oral
rat 		lowest published toxic dose: 7.5 mg/kg (7-21 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Delayed effects 		TOLED5 157,189,2005
oral
rat 		lowest published toxic dose: 26 mg/kg (18-22 day pregnant/21 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Behavioral 		TXCYAC 212,135,2005
oral
rat 		lowest published toxic dose: 2.6 mg/kg (6-22 day pregnant/10 day after birth) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Effects on newborn: Biochemical and metabolic 		TOXID9 90,292,2006
oral
rat 		lowest published toxic dose: 213,000 µg/kg (71 day male/71 day prior to copulation) Reproductive: Maternal effects: Menstrual cycle changes or disorders

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Sex ratio 		NTPTR* RACB-20102
oral
rat 		lowest published toxic dose: 1,500 µg/kg (multigenerations) Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) 		NTPTR* RACB-20102
oral
rat 		lowest published toxic dose: 1,500 µg/kg (multigenerations) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTPTR* RACB-20102
oral
rat 		lowest published toxic dose: 400 µg/kg (multigenerations) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Physical 		NTPTR* RACB-20102
oral
rat 		lowest published toxic dose: 100 µg/kg (multigenerations) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Effects on newborn: Physical 		NTPTR* RACB-20102
oral
rat 		lowest published toxic dose: 12.4 mg/kg (7-21 day pregnant/1-16 after birth) Reproductive: Effects on newborn: Behavioral REPTED 22,263,2006
oral
rat 		lowest published toxic dose: 26 mg/kg (18 day pregnant-21 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Behavioral 		NRTXDN 27,284,2006
oral
rat 		lowest published toxic dose: 14,100 µg/kg (7-21 day pregnant) Reproductive: Effects on newborn: Other postnatal measures or effects

Reproductive: Effects on newborn: Delayed effects 		TOLED5 157,189,2005
oral
rat 		lowest published toxic dose: 7.4 mg/kg (6 day pregnant-21 day after birth) Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Other postnatal measures or effects 		NETEEC 29,398,2007
oral
rat 		lowest published toxic dose: 18.5 mg/kg (7-22 day pregnant/21 day after birth) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Biochemical and metabolic 		NSAPCC 372(Suppl 1),100,2006
oral
rabbit 		lowest published toxic dose: 330 mg/kg (11-25 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Endocrine system 		SURGAZ 41,619,1957
oral
woman 		lowest published toxic dose: 1,818 mg/kg (33 day prior to copulation/1-39 week pregnant) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Effects on newborn: Other neonatal measures or effects 		JAMAAP 159,848,1955
oral
woman 		lowest published toxic dose: 1,092 mg/kg (14-40 week pregnant) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Effects on newborn: Other neonatal measures or effects 		AIMEAS 46,145,1957
parenteral
mammal (species unspecified) 		lowest published toxic dose: 615 µg/kg (29-32 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system ANREAK 175,290,1973
subcutaneous
rat 		lowest published toxic dose: 72 mg/kg (10-22 day pregnant/23 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Biochemical and metabolic 		TOSCF2 76,366,2003
subcutaneous
rat 		lowest published toxic dose: 72 mg/kg (10 day pregnant-23 day after birth) Reproductive: Other developmental abnormalities TOXID9 66,148,2002


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
guinea pig 		lowest published toxic dose: 37 gm/kg/2 year- continuous Tumorigenic: Neoplastic by RTECS criteria

Endocrine: Thyroid tumors 		GROWAH 27,305,1963
oral
hamster 		lowest published toxic dose: 653 gm/kg/70 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Endocrine: Thyroid tumors 		CANCAR 21,952,1968
oral
mouse 		lowest published toxic dose: 600 gm/kg/73 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Tumors 		PSEBAA 112,365,1963


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published lethal dose: 400 mg/kg N/R JPETAB 97,478,1949
oral
child 		lowest published toxic dose: 900 mg/kg/60 day- intermittent Liver: Hepatitis (hepatocellular necrosis), diffuse

Liver: Jaundice, other or unclassified 		AIMEAS 82,228,1975
oral
child 		lowest published toxic dose: 165 mg/kg/2 week- intermittent Liver: Hepatitis (hepatocellular necrosis), diffuse DICPBB 19,669,1985
oral
child 		lowest published toxic dose: 1,785 mg/kg/17 week- intermittent Liver: Jaundice, other or unclassified

Kidney, Ureter, and Bladder: Other changes in urine composition 		JPGND6 7,776,1988
oral
man 		lowest published toxic dose: 257 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) PGMJAO 73,445,1997
oral
man 		lowest published toxic dose: 42,857 µg/kg/10 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Interstitial nephritis

Kidney, Ureter, and Bladder: Urine volume decreased or anuria 		AJKDDP 24,575,1994
oral
man 		lowest published toxic dose: 116 mg/kg/11 week- intermittent Liver: Other changes AIMDAP 135,319,1975
oral
rat 		lethal dose (50 percent kill): 1,250 mg/kg N/R NATUAS 157,659,1946
oral
rat 		lowest published toxic dose: 8.5 mg/kg Endocrine: Evidence of thyroid hypofunction BIJOAK 47,77,1950
oral
woman 		lowest published lethal dose: 480 mg/kg/9 week- intermittent Vascular: Other changes

Blood: Angranulocytosis 		SMJOAV 75,1297,1982
oral
woman 		lowest published toxic dose: 900 mg/kg/21 week- intermittent Liver: Other changes AIMDAP 140,1184,1980
oral
woman 		lowest published lethal dose: 84 mg/kg/2 week- intermittent Liver: Hepatitis (hepatocellular necrosis), diffuse AIMDAP 142,838,1982
oral
woman 		lowest published toxic dose: 693 mg/kg/11 week- intermittent Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring)

Liver: Jaundice, other or unclassified 		SMJOAV 87,943,1994
unreported route
mouse 		lowest published lethal dose: 750 µg/kg N/R NIIRDN 6,732,1982
unreported route
rat 		lowest published lethal dose: 750 µg/kg N/R NIIRDN 6,732,1982
unreported route
woman 		lowest published lethal dose: 6 mg/kg Vascular: Shock

Liver: Hepatitis (hepatocellular necrosis), zonal

Blood: Changes in spleen 		NEJMAG 249,814,1953


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 3,750 µg/kg/15 day- intermittent Endocrine: Other changes TOSCF2 51,54,1999
intraperitoneal
rat 		lowest published toxic dose: 26 µg/kg/14 week- intermittent Liver: Changes in liver weight

Endocrine: Changes in thyroid weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TOSCF2 51,54,1999
oral
cat 		lowest published toxic dose: 1,974 mg/kg/25 week- intermittent Blood: Other changes

Immunological Including Allergic: Uncharacterized (multiple organ involvement)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TXCYAC 114,155,1996
oral
man 		lowest published toxic dose: 60 mg/kg/2 week- intermittent Liver: Jaundice, cholestatic

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		HOKMJ* 9,377,2003
oral
rat 		lowest published toxic dose: 910 mg/kg/13 week- intermittent Endocrine: Changes in thyroid weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		TXAPA9 36,49,1976
oral
rat 		lowest published toxic dose: 1,400 mg/kg/4 week- continuous Endocrine: Evidence of thyroid hypofunction

Endocrine: Changes in thyroid weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		IJEBA6 36,148,1998
oral
rat 		lowest published toxic dose: 12,600 µg/kg/21 day- continuous Endocrine: Other changes

Endocrine: Changes in thyroid weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		TOSCF2 49,263,1999
oral
rat 		lowest published toxic dose: 18 mg/kg/36 day- continuous Endocrine: Evidence of thyroid hypofunction

Biochemical: Metabolism (intermediary): Other 		ETOPFR 9,103,2001
oral
rat 		lowest published toxic dose: 140 mg/kg/14 day- intermittent Endocrine: Evidence of thyroid hyperfunction

Endocrine: Changes in thyroid weight 		TXAPA9 111,263,1991
oral
rat 		lowest published toxic dose: 70 mg/kg/7 day- intermittent Liver: Other changes

Endocrine: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) 		TXAPA9 111,263,1991
oral
rat 		lowest published toxic dose: 1,400 mg/kg/14 day- continuous Brain and Coverings: Other degenerative changes

Endocrine: Evidence of thyroid hypofunction 		HICHJ* 27,370,1995
oral
rat 		lowest published toxic dose: 7,980 mg/kg/19 week- continuous Endocrine: Other changes

Endocrine: Changes in thymus weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		JJCREP 78,1335,1987
oral
rat 		lowest published toxic dose: 1,400 mg/kg/2 week- intermittent Endocrine: Evidence of thyroid hypofunction

Endocrine: Changes in thyroid weight 		JTSCDR 25,121,2000
oral
rat 		lowest published toxic dose: 700 mg/kg/2 week- intermittent Endocrine: Other changes JTSCDR 25,121,2000
oral
rat 		lowest published toxic dose: 1,400 mg/kg/2 week- intermittent Liver: Changes in liver weight

Endocrine: Thyroid weight (goiter)

Endocrine: Evidence of thyroid hypofunction 		JTSCDR 25,121,2000
oral
rat 		lowest published toxic dose: 11.28 mg/kg/47 day- continuous Endocrine: Evidence of thyroid hypofunction TOXID9 72,123,2003
oral
rat 		lowest published toxic dose: 9.12 mg/kg/31 day- continuous Endocrine: Evidence of thyroid hypofunction TOXID9 72,123,2003
oral
rat 		lowest published toxic dose: 140 mg/kg/2 week- intermittent Liver: Changes in liver weight

Endocrine: Changes in thyroid weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TOXID9 72,284,2003
oral
rat 		lowest published toxic dose: 1.5 mg/kg/15 day- intermittent Endocrine: Change in gonadotropins TOSCF2 69,79,2002
oral
rat 		lowest published toxic dose: 150 mg/kg/15 day- intermittent Liver: Changes in liver weight

Endocrine: Change in gonadotropins

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TOSCF2 69,79,2002
oral
rat 		lowest published toxic dose: 220 mg/kg/22 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOLED5 144,195,2003
oral
rat 		lowest published toxic dose: 280 mg/kg/28 day- intermittent Endocrine: Evidence of thyroid hyperfunction TOLED5 144,195,2003
oral
rat 		lowest published toxic dose: 2.8 mg/kg/28 day- intermittent Endocrine: Other changes TOLED5 144,195,2003
oral
rat 		lowest published toxic dose: 1.05 gm/kg/3 week- intermittent Behavioral: Change in motor activity (specific assay)

Endocrine: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		NEROEW 24,632,2001
oral
rat 		lowest published toxic dose: 1.05 gm/kg/3 week- intermittent Endocrine: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		NEROEW 24,632,2001
oral
rat 		lowest published toxic dose: 140 mg/kg/1 week- continuous Endocrine: Evidence of thyroid hypofunction

Endocrine: Change in LH

Endocrine: Change in gonadotropins 		EJPHAZ 486,343,2004
oral
rat 		lowest published toxic dose: 11.1 mg/kg/37 day- continuous Endocrine: Other changes TOXID9 44,201,2005
oral
rat 		lowest published toxic dose: 15,000 mg/kg/30 day- continuous Endocrine: Evidence of thyroid hypofunction

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TOXID9 44,113,2005
oral
rat 		lowest published toxic dose: 13.6 mg/kg/34 day- intermittent Endocrine: Thyroid weight (goiter) ARTODN 79,414,2005
oral
rat 		lowest published toxic dose: 25 mg/kg/10 day- intermittent Endocrine: Toxic goiter- hypofunction

Endocrine: Evidence of thyroid hypofunction

Endocrine: Other changes 		TOXID9 78,281,2004
oral
rat 		lowest published toxic dose: 30 mg/kg/30 day- intermittent Endocrine: Toxic goiter- hypofunction

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		ARTODN 76,495,2002
oral
rat 		lowest published toxic dose: 140 mg/kg/14 day- intermittent Liver: Changes in liver weight

Endocrine: Other changes

Endocrine: Changes in thyroid weight 		TOXID9 60,227,2001
oral
rat 		lowest published toxic dose: 7.5 mg/kg/15 day- intermittent Endocrine: Evidence of thyroid hypofunction

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		TOXID9 90,292,2006
oral
rat 		lowest published toxic dose: 106,500 µg/kg/71 day- intermittent Behavioral: Food intake (animal)

Behavioral: Fluid intake

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTPTR* RACB-20102
oral
rat 		lowest published toxic dose: 106,500 µg/kg/71 day- intermittent Brain and Coverings: Changes in brain weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Changes in adrenal weight 		NTPTR* RACB-20102
oral
rat 		lowest published toxic dose: 106,500 µg/kg/71 day- intermittent Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Related to Chronic Data: Changes in ovarian weight 		NTPTR* RACB-20102
oral
rat 		lowest published toxic dose: 106,500 µg/kg/71 day- intermittent Liver: Changes in liver weight

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Related to Chronic Data: Changes in testicular weight 		NTPTR* RACB-20102
oral
rat 		lowest published toxic dose: 28,400 µg/kg/71 day- intermittent Endocrine: Evidence of thyroid hyperfunction

Endocrine: Changes in pituitary weight

Endocrine: Changes in thyroid weight 		NTPTR* RACB-20102
oral
rat 		lowest published toxic dose: 28,400 µg/kg/71 day- intermittent Endocrine: Evidence of thyroid hypofunction NTPTR* RACB-20102
oral
rat 		lowest published toxic dose: 28,400 µg/kg/71 day- intermittent Endocrine: Changes in thyroid weight NTPTR* RACB-20102
oral
rat 		lowest published toxic dose: 28,400 µg/kg/71 day- intermittent Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands NTPTR* RACB-20102
subcutaneous
rat 		lowest published toxic dose: 72 mg/kg/36 day- intermittent Endocrine: Evidence of thyroid hypofunction TOXID9 72,120,2003
unreported route
rat 		lowest published toxic dose: 18,200 mg/kg/2 week- intermittent Endocrine: Other changes

Endocrine: Changes in thyroid weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		PHTOEH 73(Suppl 2),113,1993


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 79,-,2000
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 79,-,2000
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 79,-,2000
TOXICOLOGY REVIEW
PCNAA8 8,413,1961
TOXICOLOGY REVIEW
TJADAB 165,38,2002
TOXICOLOGY REVIEW
TJADAB 65,38,2002
TOXICOLOGY REVIEW
NEJMAG 304,538,1981
TOXICOLOGY REVIEW
TOLED5 128,117,2002
TOXICOLOGY REVIEW
DIMON* 39,678,1993
TOXICOLOGY REVIEW
MUREAV 627,59,2007
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
ARTODN 81,227,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83947;
Number of Industries 1;
Total Number of Facilities 33;
Number of Occupations 1;
Total Number of Employees Exposed 297
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83947;
Number of Industries 6;
Total Number of Facilities 330;
Number of Occupations 12;
Total Number of Employees Exposed 3,331;
Total Number of Female Employees Exposed 1,666


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an anti-thyroid agent for the treatment of hyperthyroidism
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE
AIMDAP Archives of Internal Medicine. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1908-
AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927-
AJKDDP American Journal of Kidney Diseases. (Grune & Stratton, Inc., Journal Subscription Dept., POB 6280, Duluth, MN 55806) V.1- 1981-
ANREAK Anatomical Record. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1906/08-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BIJOAK Biochemical Journal. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1906-
CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948-
CHINAG Chemistry and Industry (London). (Royal Soc. of Chemistry, Distribution Centre, Blackhorse Rd., Letchworth, Herts SG6 1HN, UK) V.1- 1923-
DICPBB Drug Intelligence and Clinical Pharmacy. (POB 42435, Cincinnati, OH 45242) V.3- 1969-
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Used as an anti-thyroid agent for the treatment of hyperthyroidism

FDA-proprietary drug

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Human Data

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