RTECS:YQ8650000 The Registry of Toxic Effects of Chemical Substances

Uracil

RTECS #: YQ8650000

CAS #: 66-22-8

UPDATE: February 2009 MW: 112.10 MF: C₄H₄N₂O₂

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

MUTATION DATA:

REPRODUCTIVE EFFECTS DATA:

TUMORIGENIC DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

REVIEWS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

2,4 (1H,3H) - Pyrimidinedione (9CI)

2,4 - Dihydroxypyrimidine

2,4 - Dioxopyrimidine

2,4 - Pyrimidinediol

2,4 - Pyrimidinedione

Hybar X

Pirod

Pyrod

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
cytogenetic analysis intraperitoneal
mouse 15 mg/kg NULSAK 19,40,1976
phage inhibition capacity Escherichia coli 1 gm/L ZAPOAK 12,583,1972

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
rat lowest published toxic dose: 18 gm/kg (17-22 day pregnant/21 day after birth) Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow)

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Behavioral OYYAA2 22,109,1981
oral
rat lowest published toxic dose: 15,400 mg/kg (7-17 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system OYYAA2 22,85,1981
oral
rat lowest published toxic dose: 616 mg/kg (7-17 day pregnant) Reproductive: Effects on newborn: Sex ratio OYYAA2 22,85,1981

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
mouse lowest published toxic dose: 1,905 gm/kg/96 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors CNREA8 52,1675,1992
oral
rat lowest published toxic dose: 131 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors

Kidney, Ureter, and Bladder: Kidney tumors CNREA8 52,1675,1992
oral
rat toxic dose : 378 gm/kg/30 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors CNREA8 46,2062,1986
oral
rat toxic dose : 454 gm/kg/36 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors CRNGDP 12,35,1991
oral
rat toxic dose : 235 gm/kg/20 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors CALEDQ 34,249,1987
oral
rat toxic dose : 189 gm/kg/15 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors CALEDQ 58,81,1991

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intraperitoneal
mouse lethal dose (50 percent kill): 1,513 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay) JPETAB 207,504,1978
oral
dog lethal dose (50 percent kill): >5 gm/kg N/R MDACAP 21,125,1985
oral
mouse lethal dose (50 percent kill): >8 gm/kg N/R OYYAA2 20,1009,1980
oral
rat lethal dose (50 percent kill): >6 gm/kg N/R MDACAP 21,125,1985
oral
rabbit lethal dose (50 percent kill): >10 gm/kg N/R MDACAP 21,125,1985

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
rat lowest published toxic dose: 271.488 gm/kg/32 week- continuous Tumorigenic: Protects against induction of experimental tumors JTPAE7 18,105,2005

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
CAINV* 18,747,2000
TOXICOLOGY REVIEW
MUREAV 584,1,2005

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X9246;
Number of Industries 6;
Total Number of Facilities 737;
Number of Occupations 13;
Total Number of Employees Exposed 5,593;
Total Number of Female Employees Exposed 2,969

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY

REFERENCES:
CODEN
REFERENCE

CAINV* Cancer investigation (New York, N.Y. : Marcel Dekker) V.1- 1983-
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JTPAE7 Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1988
MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NULSAK Nucleus (Calcutta). (Dr. A.K. Sharma, Centre of Advanced Studies in Cell and Chromosome Research, Calcutta, 35 Baliygunge Circular Rd., Calcutta 700 019, India) V.1- 1958-
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967-
ZAPOAK Zeitschrift fuer Allgemeine Mikrobiologie. (Akademie-Verlag GmbH, Postfach 1233, Berlin DDR-1086 Ger. Dem. Rep.) V.1- 1960-

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector

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SYNONYMS:
2,4 (1H,3H) - Pyrimidinedione (9CI) 2,4 - Dihydroxypyrimidine 2,4 - Dioxopyrimidine 2,4 - Pyrimidinediol	2,4 - Pyrimidinedione Hybar X Pirod Pyrod

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
cytogenetic analysis	intraperitoneal mouse	15 mg/kg	NULSAK 19,40,1976
phage inhibition capacity	Escherichia coli	1 gm/L	ZAPOAK 12,583,1972

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
oral rat	lowest published toxic dose: 18 gm/kg (17-22 day pregnant/21 day after birth)	Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow) Reproductive: Specific developmental abnormalities: Urogenital system Reproductive: Effects on newborn: Behavioral	OYYAA2 22,109,1981
oral rat	lowest published toxic dose: 15,400 mg/kg (7-17 day pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Musculoskeletal system	OYYAA2 22,85,1981
oral rat	lowest published toxic dose: 616 mg/kg (7-17 day pregnant)	Reproductive: Effects on newborn: Sex ratio	OYYAA2 22,85,1981

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
oral mouse	lowest published toxic dose: 1,905 gm/kg/96 week- continuous	Tumorigenic: Carcinogenic by RTECS criteria Kidney, Ureter, and Bladder: Bladder tumors	CNREA8 52,1675,1992
oral rat	lowest published toxic dose: 131 gm/kg/2 year- continuous	Tumorigenic: Carcinogenic by RTECS criteria Kidney, Ureter, and Bladder: Bladder tumors Kidney, Ureter, and Bladder: Kidney tumors	CNREA8 52,1675,1992
oral rat	toxic dose : 378 gm/kg/30 week- continuous	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, and Bladder: Bladder tumors	CNREA8 46,2062,1986
oral rat	toxic dose : 454 gm/kg/36 week- continuous	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, and Bladder: Bladder tumors	CRNGDP 12,35,1991
oral rat	toxic dose : 235 gm/kg/20 week- continuous	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, and Bladder: Bladder tumors	CALEDQ 34,249,1987
oral rat	toxic dose : 189 gm/kg/15 week- continuous	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, and Bladder: Bladder tumors	CALEDQ 58,81,1991

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intraperitoneal mouse	lethal dose (50 percent kill): 1,513 mg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Change in motor activity (specific assay)	JPETAB 207,504,1978
oral dog	lethal dose (50 percent kill): >5 gm/kg	N/R	MDACAP 21,125,1985
oral mouse	lethal dose (50 percent kill): >8 gm/kg	N/R	OYYAA2 20,1009,1980
oral rat	lethal dose (50 percent kill): >6 gm/kg	N/R	MDACAP 21,125,1985
oral rabbit	lethal dose (50 percent kill): >10 gm/kg	N/R	MDACAP 21,125,1985

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
oral rat	lowest published toxic dose: 271.488 gm/kg/32 week- continuous	Tumorigenic: Protects against induction of experimental tumors	JTPAE7 18,105,2005

REVIEWS:
ORGANIZATION	STANDARD	REFERENCE
TOXICOLOGY REVIEW		CAINV* 18,747,2000
TOXICOLOGY REVIEW		MUREAV 584,1,2005

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
N/R	N/R	N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: X9246; Number of Industries 6; Total Number of Facilities 737; Number of Occupations 13; Total Number of Employees Exposed 5,593; Total Number of Female Employees Exposed 2,969

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY

REFERENCES:
CODEN	REFERENCE
CAINV*	Cancer investigation (New York, N.Y. : Marcel Dekker) V.1- 1983-
CALEDQ	Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CNREA8	Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CRNGDP	Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
JPETAB	Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JTPAE7	Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1988
MDACAP	Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965-
MUREAV	Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NULSAK	Nucleus (Calcutta). (Dr. A.K. Sharma, Centre of Advanced Studies in Cell and Chromosome Research, Calcutta, 35 Baliygunge Circular Rd., Calcutta 700 019, India) V.1- 1958-
OYYAA2	Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967-
ZAPOAK	Zeitschrift fuer Allgemeine Mikrobiologie. (Akademie-Verlag GmbH, Postfach 1233, Berlin DDR-1086 Ger. Dem. Rep.) V.1- 1960-