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Tubocurarine, dichloride, (+) -

RTECS #: YO4900000

CAS #: 57-94-3

UPDATE: July 1997 MW: 695.74 MF: C38H44N2O6•2Cl


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. NIOSH DOCUMENTATION AND SURVEILLANCE:
  4. STATUS IN FEDERAL AGENCIES:
  5. REFERENCES:

SYNONYMS:

  1. (+) - Tubocurarine chloride
  2. (+) - Tubocurarine hydrochloride
  3. Amerizol
  4. Curarin - haf
  5. Delacurarine
  6. Dextrotubocurarine chloride
  7. Intocostrin
  8. Intocostrine T
  9. Tubadil
  1. Tubarine
  2. Tubocurarine chloride
  3. Tubocurarine, chloride, hydrochloride, (+) - (8CI)
  4. Tubocurarine hydrochloride
  5. d - 7',12' - Dihydroxy - 6,6' - dimethoxy - 2,2',2' - trimethyltubocuraranium chloride
  6. d - Paracurarine chloride
  7. d - Tubocurarine chloride
  8. d - Tubocurarine dichloride
  9. d - Tubocurarine hydrochloride


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
mouse 		lethal dose (50 percent kill): 540 µg/kg N/R KHFZAN 24(12),24,1990
intraperitoneal
mouse 		lethal dose (50 percent kill): 420 µg/kg N/R RPTOAN 32,74,1969
intraperitoneal
rat 		lethal dose (50 percent kill): 340 µg/kg Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Respiratory depression

Lung, Thorax, or Respiration: Other changes 		OYYAA2 9,117,1975
intravenous
guinea pig 		lethal dose (50 percent kill): 66 µg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Other changes 		JLCMAK 34,516,1949
intravenous
mouse 		lethal dose (50 percent kill): 97 µg/kg N/R AIPTAK 109,191,1957
intravenous
rat 		lethal dose (50 percent kill): 66 µg/kg Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Respiratory depression

Lung, Thorax, or Respiration: Other changes 		OYYAA2 9,117,1975
intravenous
rabbit 		lethal dose (50 percent kill): 170 µg/kg N/R KHFZAN 24(12),24,1990
oral
mouse 		lethal dose (50 percent kill): 33 mg/kg N/R PSEBAA 120,511,1965
oral
rat 		lethal dose (50 percent kill): 28 mg/kg N/R PSEBAA 120,511,1965
subcutaneous
mouse 		lethal dose (50 percent kill): 640 µg/kg Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Respiratory depression

Lung, Thorax, or Respiration: Other changes 		OYYAA2 9,117,1975
subcutaneous
rat 		lethal dose (50 percent kill): 310 µg/kg Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Respiratory depression

Lung, Thorax, or Respiration: Other changes 		OYYAA2 9,117,1975


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5569;
Number of Industries 1;
Total Number of Facilities 34;
Number of Occupations 3;
Total Number of Employees Exposed 1,010;
Total Number of Female Employees Exposed 668


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9; Histidine reversion-Ames test


REFERENCES:

CODEN
REFERENCE
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
JLCMAK Journal of Laboratory and Clinical Medicine. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1915-
KHFZAN Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967-
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967-
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967-

Used as a muscle relaxant

RTECS Compound Description:
   Drug
   Mutagen

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