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Trypsin inhibitor, pancreatic basic

RTECS #: YN5080000

CAS #: 9087-70-1

UPDATE: August 2008 MW: 6,512.42 MF: C284H432N84O79S7


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. REFERENCES:

SYNONYMS:

  1. Antikrein
  2. Antilysin
  3. Antilysine
  4. Aprotinin
  5. Basic pancreatic trypsin inhibitor
  6. Bayer A - 128
  7. Fosten
  8. Kallikrein - trypsin inactivator
  9. Kir richter
  10. Onquinin
  11. Pancreatic basic trypsin inhibitor
  1. Pancreatic trypsin inhibitor
  2. Pancreatic trypsin inhibitor (kunitz)
  3. RP - 9921
  4. Repulson
  5. Riker 52G
  6. Trasylol
  7. Trasysols
  8. Trazinin
  9. Trypsin inhibitor
  10. Trypsin - kallikrein inhibitor (kunitz)
  11. Zymofren


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intrauterine
mouse 		lowest published toxic dose: 160 mg/kg (2 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) FESTAS 25,954,1974


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): >50 mL/kg Behavioral: Somnolence (general depressed activity) OYYAA2 28,329,1984
intraperitoneal
mouse 		lowest published toxic dose: 8 mg/kg Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation TOXIA6 49,663,2007
intraperitoneal
rat 		lethal dose (50 percent kill): >40 mL/kg Behavioral: Somnolence (general depressed activity) OYYAA2 28,329,1984
intraperitoneal
rat 		lowest published toxic dose: 10,000 units/kg Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) FATOAO 50,64,1987
intravenous
human 		lowest published toxic dose: 100,000,000 units/kg Blood: Other changes CYLPDN 22,913,2001
intravenous
rat 		lowest published toxic dose: 50,000 units/kg/24 hour Cardiac: Cardiomyopathy including infarction BJPCBM 138,225,2003
intravenous
rat 		lowest published toxic dose: 4 mg/kg Vascular: BP elevation not characterized in autonomic section TOXIA6 49,663,2007
subcutaneous
mouse 		lethal dose (50 percent kill): >50 mL/kg Behavioral: Somnolence (general depressed activity) OYYAA2 28,329,1984
subcutaneous
mouse 		lowest published toxic dose: 10,000 units/kg Behavioral: Analgesia FATOAO 51,66,1988
subcutaneous
rat 		lethal dose (50 percent kill): >40 mL/kg Behavioral: Somnolence (general depressed activity) OYYAA2 28,329,1984


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
MUREAV 488,151,2001
TOXICOLOGY REVIEW
TOPADD 33,517,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X9526;
Number of Industries 2;
Total Number of Facilities 141;
Number of Occupations 5;
Total Number of Employees Exposed 1,132;
Total Number of Female Employees Exposed 938


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968-
CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980-
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967-
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978-
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962-

Used as a proteinase inhibitor

RTECS Compound Description:
   Drug
   Reproductive Effector
   Human Data

ALT CAS #: 9004-04-0
ALT CAS #: 9039-77-4
ALT CAS #: 39283-52-8
ALT CAS #: 69431-34-1
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