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1 - alpha - H,5 - alpha - H - Tropane, 3 - alpha - (diphenylmethoxy) - , methanesulfonate

RTECS #: YM3150000

CAS #: 132-17-2

UPDATE: February 2003 MW: 403.58 MF: C21H25NO•CH4O3S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. REFERENCES:

SYNONYMS:

  1. 3 - Diphenylmethoxytropane mesylate
  2. 3 - Diphenylmethoxytropane methanesulfonate
  3. 3 - alpha - (Diphenylmethoxy) - 1 - alpha - H, 5 - alpha - H - tropane methanesulfonate
  4. 8 - Azabicyclo (3.2.1) octane, 3 - (diphenylmethoxy) - , endo - , methanesulfonate
  5. Benzatropine methanesulfonate
  6. Benzotropine mesylate
  7. Benzotropine methanesulfonate
  8. Benztropine mesilate
  1. Benztropine mesylate
  2. Benztropine methanesulfonate
  3. Cobrentin methanesulfonate
  4. Cogentin
  5. Cogentin mesylate
  6. Cogentin methanesulfonate
  7. MK 02
  8. Tropine benzohydryl ether methanesulfonate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA adduct Escherichia coli 10 µmol/L MUREAV 89,95,1981


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 65 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression 		AIPTAK 144,555,1963
intravenous
cat 		lowest published lethal dose: 33 mg/kg N/R CLDND*
intravenous
mouse 		lethal dose (50 percent kill): 24 mg/kg N/R 27ZQAG -,208,1972
oral
human 		lowest published toxic dose: 100 µg/kg Behavioral: Toxic psychosis PSDTAP 8,59,1967
oral
mouse 		lethal dose (50 percent kill): 91 mg/kg N/R NIIRDN 6,775,1982
oral
rat 		lethal dose (50 percent kill): 940 mg/kg N/R NIIRDN 6,775,1982
subcutaneous
guinea pig 		lethal dose (50 percent kill): 80 mg/kg Autonomic Nervous System: Parasympatholytic AIPTAK 137,375,1962
subcutaneous
mouse 		lethal dose (50 percent kill): 103 mg/kg N/R 27ZQAG -,208,1972
subcutaneous
rat 		lethal dose (50 percent kill): 353 mg/kg N/R 27ZQAG -,208,1972
subcutaneous
rat 		lowest published toxic dose: 3 mg/kg Behavioral: Change in psychophysiological tests JPETAB 294,1017,2000


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5595;
Number of Industries 1;
Total Number of Facilities 46;
Number of Occupations 1;
Total Number of Employees Exposed 1,071;
Total Number of Female Employees Exposed 681


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
PSDTAP Proceedings of the European Society for the Study of Drug Toxicity. (Princeton, NJ 08540) V.1-15, 1963-74. For publisher information, see PESTD5.

Used as an anticholinergic agent

FDA-proprietary drug

RTECS Compound Description:
   Drug
   Mutagen
   Human Data

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