The Registry of Toxic Effects of Chemical Substances

Triethylamine, 2,2',2'' - trichloro -

RTECS #: YE2625000

CAS #: 555-77-1

UPDATE: November 2007 MW: 204.54 MF: C6H12Cl3N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. REVIEWS:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 2,2',2'' - Trichlorotriethylamine
  2. HN 3
  3. HN3
  4. Mechlorethamine
  5. TL 145
  1. TS 160
  2. Tri - (2 - chloroethyl) amine
  3. Tris (2 - chloroethyl) amine
  4. Tris (beta - chloroethyl) amine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		400 µg N/R AJOPAA 29,1553,1946


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA inhibition hamster lung 3 mg/L MUREAV 116,431,1983
DNA inhibition human fibroblast 10 mg/L STBIBN 78,165,1980
mutation in microorganisms Escherichia coli 1 mmol/L (-enzymatic activation step) MUREAV 210,255,1989
mutation in mammalian somatic cells hamster lung 1 mg/L MUREAV 116,431,1983
sex chromosome loss and nondisjunction inhalation
Drosophila melanogaster 		100 pph/5 minute PREBA3 62,284,1946/1947


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
subcutaneous
rat 		lowest published toxic dose: 18 mg/kg/26 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Tumorigenic: Tumors at site of application 		NEOLA4 28,565,1981
subcutaneous
rat 		toxic dose : 45 mg/kg/26 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Tumorigenic: Tumors at site of application 		NEOLA4 28,565,1981
subcutaneous
rat 		toxic dose : 180 mg/kg/26 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Tumorigenic: Tumors at site of application 		NEOLA4 28,565,1981


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lethal concentration (50 percent kill): 80 mg/m3/10 minute N/R NTIS** PB158-508
inhalation
dog 		lethal concentration (50 percent kill): 100 mg/m3/10 minute N/R NTIS** PB158-508
inhalation
guinea pig 		lethal concentration (50 percent kill): >200 mg/m3/10 minute N/R NTIS** PB158-508
inhalation
mouse 		lethal concentration (50 percent kill): 120 mg/m3/10 minute N/R NTIS** PB158-508
inhalation
rat 		lethal concentration (50 percent kill): 200 mg/m3/10 minute N/R NTIS** PB158-508
inhalation
rabbit 		lethal concentration (50 percent kill): 140 mg/m3/10 minute N/R NTIS** PB158-508
intravenous
dog 		lowest published lethal dose: 1 mg/kg N/R NTIS** PB158-507
intravenous
dog 		lethal dose (50 percent kill): 1 mg/kg N/R ENTOX* -,241,2005
intravenous
mouse 		lethal dose (50 percent kill): 1 mg/kg N/R ENTOX* -,241,2005
intravenous
rat 		lethal dose (50 percent kill): 0.7 mg/kg N/R ENTOX* -,241,2005
intravenous
rabbit 		lethal dose (50 percent kill): 2.5 mg/kg N/R ENTOX* -,241,2005
oral
wild bird 		lethal dose (50 percent kill): 31,600 µg/kg N/R AECTCV 12,355,1983
oral
quail 		lethal dose (50 percent kill): 133 mg/kg N/R JRPFA4 48,371,1976
oral
rat 		lethal dose (50 percent kill): 2.5 mg/kg N/R ENTOX* -,241,2005
subcutaneous
dog 		lethal dose (50 percent kill): 20 mg/kg N/R NTIS** PB158-507
subcutaneous
guinea pig 		lethal dose (50 percent kill): 7 mg/kg N/R NTIS** PB158-507
subcutaneous
mouse 		lethal dose (50 percent kill): 6,900 µg/kg Behavioral: Convulsions or effect on seizure threshold NTIS** PB158-507
subcutaneous
mouse 		lethal dose (50 percent kill): 2 mg/kg N/R ENTOX* -,241,2005
subcutaneous
rat 		lethal dose (50 percent kill): 2 mg/kg N/R ENTOX* -,241,2005
subcutaneous
rabbit 		lethal dose (50 percent kill): 2 mg/kg N/R ENTOX* -,241,2005
skin
dog 		lethal dose (50 percent kill): 1 mg/kg N/R JPETAB 91,224,1947
skin
domestic animal 		lethal dose (50 percent kill): 20 mg/kg N/R NTIS** PB158-507
skin
guinea pig 		lethal dose (50 percent kill): 20 mg/kg N/R NTIS** PB158-507
skin
human 		lethal dose (50 percent kill): 10 mg/kg N/R ENTOX* -,241,2005
skin
mouse 		lethal dose (50 percent kill): 7 mg/kg N/R ENTOX* -,241,2005
skin
rat 		lethal dose (50 percent kill): 2 mg/kg N/R NTIS** PB158-507
skin
rabbit 		lethal dose (50 percent kill): 5 mg/kg Behavioral: Convulsions or effect on seizure threshold NTIS** PB158-507
skin
rabbit 		lethal dose (50 percent kill): 19 mg/kg N/R ENTOX* -,241,2005
unreported route
rat 		lethal dose (50 percent kill): 2,500 µg/kg N/R PHBUA9 1,297,1953


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
CHREAY 48,225,1951
TOXICOLOGY REVIEW
ENTOX* -,241,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Aspergillus-reversion; D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
CHREAY Chemical Reviews. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1924-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NEOLA4 Neoplasma. (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland) V.4- 1957-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PHBUA9 Pharmaceutical Bulletin. (Tokyo, Japan) V.1-5, 1953-57. For publisher information, see CPBTAL.
PREBA3 Proceedings of the Royal Society of Edinburgh, Section B. (Edinburgh, Scotland, UK) V.61-74, 1943-74.
STBIBN Studia Biophysica. (Akademie-Verlag GmbH, Postfach 1233, Berlin DDR-1086, Ger. Dem. Rep.) V.1- 1966-

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Drug
   Mutagen
   Human Data
   Primary Irritant

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