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1,3,5 - Triazin - 2 (1H) - one, 4 - amino - 1 - beta - D - ribofuranosyl -

RTECS #: XZ3017500

CAS #: 320-67-2

UPDATE: May 2009 MW: 244.24 MF: C8H12N4O5


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 4 - Amino - 1 - beta - D - ribofuranosyl - s - triazin - 2 (1H) - one
  2. 5 - AC
  3. 5 - Azacytidine
  4. Antibiotic U 18496
  5. Azacitidine
  6. Azacytidine
  7. Ladakamycin
  1. Mylosar
  2. NCI - C01569
  3. NSC - 102816
  4. U 18496
  5. WR - 183027
  6. s - Triazin - 2 (1H) - one, 4 - amino - 1 - beta - D - ribofuranosyl - (8CI)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		45 mg/24 hour rinse N/R TXCYAC 14,117,1979


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster embryo 5 mg/L CNREA8 37,2202,1977
cytogenetic analysis hamster lung 20 µmol/L MUREAV 212,253,1989
cytogenetic analysis hamster fibroblast 1 µmol/L/1 hour TCMUD8 23,171,2003
cytogenetic analysis hamster ovary 1 µmol/L/1 hour TCMUD8 23(Suppl 1),171,2003
cytogenetic analysis human lymphocyte 10 µmol/L HUGEDQ 71,342,1985
cytogenetic analysis human other cell types 20 µmol/L/5 hour MUTAEX 16,109,2001
cytogenetic analysis human mammary gland 6 µmol/L/8 hour MUTAEX 16,109,2001
cytogenetic analysis mammal (species unspecified) lymphocyte 400 nmol/L CGCGBR 41,71,1986
cytogenetic analysis intraperitoneal
mouse 		3 mg/kg NEOLA4 20,243,1973
cytogenetic analysis mouse embryo 10 µmol/L EXPEAM 30,1463,1974
cytogenetic analysis mouse fibroblast 1 µmol/L/8 hour MUTAEX 16,109,2001
DNA damage human HeLa cell 120 µmol/L MUREAV 226,185,1989
DNA damage human fibroblast 1 µmol/L PNASA6 79,2352,1982
DNA damage human lymphocyte 0.9 mg/L/48 hour MUREAV 607,160,2006
DNA inhibition human other cell types 5 µmol/L CRNGDP 9,2155,1988
DNA inhibition human leukocyte 3 µmol/L CNREA8 43,763,1983
DNA inhibition intraperitoneal
mouse 		7,143 µg/kg/3 day- continuous NEOLA4 12,3,1965
unscheduled DNA synthesis intraperitoneal
mouse 		3 mg/kg NEOLA4 20,243,1973
unscheduled DNA synthesis intraperitoneal
rat 		50 µmol/kg CNREA8 36,37,1976
mutation in microorganisms Escherichia coli 1 mg/L (-enzymatic activation step) MUREAV 193,229,1988
mutation in microorganisms Escherichia coli 5 µg/plate/48 hour MUTAEX 15,317,2000
mutation in microorganisms other microorganisms 10 mg/L (-enzymatic activation step) VIRLAX 74,154,1976
mutation in microorganisms other microorganisms 15 mg/L (-enzymatic activation step) JOVIAM 16,1000,1975
mutation in microorganisms other microorganisms 5 mg/L (-enzymatic activation step) JOVIAM 2,1228,1968
mutation in microorganisms other microorganisms 25 mg/L (-enzymatic activation step) JOVIAM 7,295,1971
mutation in microorganisms Salmonella typhimurium 2 µg/plate (+enzymatic activation step) MUREAV 121,1,1983
mutation in microorganisms Salmonella typhimurium 3 µg/plate (-enzymatic activation step) EMMUEG 19(Suppl 21),2,1992
mutation in microorganisms Salmonella typhimurium 0.9 mg/L/2 hour (-enzymatic activation step) MUREAV 578,210,2005
mutation in microorganisms Salmonella typhimurium 2.8 mg/L/2 hour (+enzymatic activation step) MUREAV 578,210,2005
mutation in microorganisms Saccharomyes cerevisiae 625 mg/L/16 hour MUTAEX 20,105,2004
micronucleus test hamster embryo 5 µmol/L MUREAV 283,21,1992
micronucleus test human lymphocyte 10 µmol/L/24 hour MUREAV 528,61,2003
micronucleus test intraperitoneal
mouse 		39 mg/kg MUREAV 271,13,1992
micronucleus test mouse lymphocyte 1 µmol/L MUREAV 300,165,1993
micronucleus test mouse mammary gland 1.77 mg/L/24 hour (-enzymatic activation step) MUREAV 540,153,2003
gene conversion and mitotic recombination oral
Drosophila melanogaster 		244 mg/L MUREAV 266,93,1992
mutation in mammalian somatic cells hamster lung 1 µmol/L MUREAV 212,253,1989
mutation in mammalian somatic cells hamster ovary 12 µmol/L EMMUEG 28,100,1996
mutation in mammalian somatic cells human lymphocyte 100 nmol/L MUREAV 160,249,1986
mutation in mammalian somatic cells mouse lymphocyte 22 µg/L/3 hour- continuous PAACA3 27,90,1986
morphological transform hamster embryo 200 nmol/L MUREAV 283,21,1992
morphological transform mouse fibroblast 750 µg/L CBRPDS 10,789,1986
morphological transform mouse embryo 250 µg/L CNREA8 37,2202,1977
other mutation test systems Escherichia coli 1 mg/L MUREAV 193,229,1988
other mutation test systems hamster embryo 10 µmol/L MUREAV 283,21,1992
other mutation test systems intraperitoneal
mouse 		7,143 µg/kg/3 day- continuous NEOLA4 12,3,1965
other mutation test systems intraperitoneal
mouse 		3 mg/kg NEOLA4 20,243,1973
other mutation test systems mouse embryo 10 µmol/L EXPEAM 30,1463,1974
other mutation test systems other microorganisms 25 gm/L MGBUA3 30,9,1969
other mutation test systems subcutaneous
rat 		25 mg/kg NEOLA4 32,293,1985
phage inhibition capacity Escherichia coli 20 mg/L MUREAV 166,9,1986
sister chromatid exchange hamster ovary 10 µmol/L CRNGDP 8,1059,1987
sister chromatid exchange hamster fibroblast 2,500 µg/L CNREA8 39,797,1979
sister chromatid exchange human lymphocyte 9 µmol/L EMMUEG 14,6,1989
sex chromosome loss and nondisjunction oral
Drosophila melanogaster 		1 gm/L EMMUEG 14,135,1989
specific locus test oral
Drosophila melanogaster 		1 mmol/L MUREAV 143,195,1985
specific locus test hamster ovary 3 mg/L/20 hour MUTAEX 15,25,2000


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 5 mg/kg (12 day pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) 		TCMUD8 7,7,1987
intraperitoneal
mouse 		lowest published toxic dose: 500 µg/kg (7 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death 		TJADAB 41,147,1990
intraperitoneal
mouse 		lowest published toxic dose: 1 mg/kg (7 day pregnant) Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material)

Reproductive: Specific developmental abnormalities: Central nervous system 		TJADAB 30(1),9A,1984
intraperitoneal
mouse 		lowest published toxic dose: 2 mg/kg (10 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Central nervous system 		ARTODN 55,143,1984
intraperitoneal
mouse 		lowest published toxic dose: 2 mg/kg (11 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Other developmental abnormalities 		ARTODN 55,143,1984
intraperitoneal
rat 		lowest published toxic dose: 5 mg/kg (5 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) IJDBE5 43,843,1999
intraperitoneal
rat 		lowest published toxic dose: 1 mg/kg (9 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death 		JTEHD6 29,201,1990
intraperitoneal
rat 		lowest published toxic dose: 600 µg/kg (13 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		CGANE7 29,59,1989
intraperitoneal
rat 		lowest published toxic dose: 4 mg/kg (17 day pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Behavioral 		FCTOD7 22,963,1984
intraperitoneal
rat 		lowest published toxic dose: 450 µg/kg (13 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TJADAB 35,247,1987
parenteral
mouse 		lowest published toxic dose: 500 µg/kg (12 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Behavioral 		TJADAB 19,327,1979
parenteral
mouse 		lowest published toxic dose: 100 µg/kg (12 day pregnant) Reproductive: Effects on newborn: Physical ANREAK 193,665,1979
parenteral
mouse 		lowest published toxic dose: 500 µg/kg (12 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system NETOD7 1,129,1979
unreported route
mouse 		lowest published toxic dose: 500 µg/kg (12 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) TJADAB 17,43A,1978
unreported route
mouse 		lowest published toxic dose: 4 mg/kg (15 day pregnant) Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material) TJADAB 4,234,1971


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 100 mg/kg/50 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Blood: Lymphoma including Hodgkin's disease

Skin and Appendages: Tumors 		CALEDQ 37,51,1987
intraperitoneal
mouse 		toxic dose : 284 mg/kg/43 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Blood: Lymphoma including Hodgkin's disease 		NCITR* NCI-TR-42,1978
intraperitoneal
mouse 		toxic dose : 100 mg/kg/50 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		CALEDQ 37,51,1987
intraperitoneal
mouse 		toxic dose : 90 mg/kg/8 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		CNREA8 33,3069,1973
intraperitoneal
mouse 		toxic dose : 1 mg/kg (12 day pregnant) Tumorigenic: Carcinogenic by RTECS criteria

Blood: Lymphoma including Hodgkin's disease

Reproductive: Tumorigenic effects: Transplacental tumorigenesis 		CALEDQ 27,81,1985
intraperitoneal
rat 		lowest published toxic dose: 190 mg/kg/38 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Reproductive: Tumorigenic effects: Testicular tumors 		CRNGDP 5,1583,1984
unreported route
mouse 		lowest published toxic dose: 1 mg/kg (16 day pregnant) Tumorigenic: Carcinogenic by RTECS criteria

Reproductive: Tumorigenic effects: Transplacental tumorigenesis

Blood: Lymphoma including Hodgkin's disease 		TJADAB 32,33A,1985


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 68 mg/kg N/R EXPEAM 22,53,1966
intraperitoneal
mouse 		lowest published toxic dose: 100 mg/kg Endocrine: Changes in spleen weight

Endocrine: Changes in thymus weight

Blood: Changes in bone marrow not included in above 		TOPADD 13,231,2000
intravenous
dog 		lethal dose (50 percent kill): 7,200 µg/kg Blood: Other changes AVPCAQ 14,285,1977
intravenous
mouse 		lethal dose (50 percent kill): 229 mg/kg Behavioral: Ataxia

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** PB84-211432
intravenous
woman 		lowest published toxic dose: 6 mg/kg/10 day- intermittent Blood: Luekopenia

Blood: Angranulocytosis 		CCROBU 56,413,1972
intravenous
woman 		lowest published toxic dose: 500 µg/kg Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting 		CCROBU 56,413,1972
oral
wild bird 		lethal dose (50 percent kill): 100 mg/kg N/R AECTCV 12,355,1983
oral
mouse 		lethal dose (50 percent kill): 572 mg/kg N/R TXAPA9 19,382,1971
oral
quail 		lethal dose (50 percent kill): >100 mg/kg N/R EESADV 6,149,1982


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
hamster 		lowest published toxic dose: 180 mg/kg/9 week- intermittent Blood: Luekopenia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		EXMPA6 53,34,1990
intravenous
monkey 		lowest published toxic dose: 30,800 µg/kg/14 day- intermittent Blood: Changes in bone marrow not included in above

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTIS** PB210-642
intravenous
mouse 		lowest published toxic dose: 32,500 µg/kg/5 day- intermittent Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle contraction or spasticity

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** PB84-211432


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 26,37,1981
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 50,47,1990
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 26,37,1981
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 50,47,1990
International Agency for Research on Cancer (IARC) Cancer Review Group 2A IMEMDT 50,47,1990
TOXICOLOGY REVIEW
REPTED 22,196,2006
TOXICOLOGY REVIEW
APHRER 39,1700,2005
TOXICOLOGY REVIEW
DIMON* 39,678,1993
TOXICOLOGY REVIEW
FCTOD7 44,1699,2006
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
MUREAV 672,10,2009
TOXICOLOGY REVIEW
MUREAV 672,17,2009


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5101;
Number of Industries 1;
Total Number of Facilities 88;
Number of Occupations 3;
Total Number of Employees Exposed 1,069;
Total Number of Female Employees Exposed 698


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-C3H/10T1/2
EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
Used as an antineoplastic agent
NCI Carcinogenesis Bioassay (ipr);clear evidence:mouse NCITR* NCI-TR-42,1978
NCI Carcinogenesis Bioassay (ipr);inadequate studies:rat NCITR* NCI-TR-42,1978
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
ANREAK Anatomical Record. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1906/08-
APHRER Annals of Pharmacotherpy. (Harvey Whitney Books Co., POB 42696, Cincinnati, OH 45242) V. 26- 1992-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
AVPCAQ Advances in Pharmacology and Chemotherapy. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.7-20, 1969-84.
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CBRPDS Cell Biology International Reports. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977-
CCROBU Cancer Chemotherapy Reports, Part 1. (Washington, DC) V.52(6)-59, 1968-75. For publisher information, see CTRRDO.
CGANE7 Congenital Anomalies. (Nippon Senten Ijo Gakkai, 377-2 Ono-higashi, Osakasayama, Osaka-Fu 589 Japan) V.27- 1987-
CGCGBR Cytogenetics and Cell Genetics. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.12- 1973-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DIMON* Disease-a Month (Chicago : Year Book Publishers) V. 24- 1978-
EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
EXMPA6 Experimental and Molecular Pathology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1962-
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
HUGEDQ Human Genetics. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.31- 1976-
IJDBE5 International Journal of Developmental Biology. (University of the Basque Country Press, POB 1397, E-48080, Bilbao, Spain) V.33- 1989-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JOVIAM Journal of Virology. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1967-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MGBUA3 Microbial Genetics Bulletin. (Ohio State Univ., College of Biological Science, Dept. of Microbiology, 484 W. 12th Ave., Columbus, OH 43210) No.1- 1950-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
NEOLA4 Neoplasma. (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland) V.4- 1957-
NETOD7 Neurobehavioral Toxicology. (Fayetteville, NY) V.1-2, 1979-80. For publisher information, see NTOTDY.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954-
PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915-
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VIRLAX Virology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1955-

Used as an antineoplastic agent

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

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