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| UPDATE: March 2000 | MW: 249.30 | MF: C12H15N3O3 |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
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ROUTE/ | ORGANISM/ TISSUE
DOSE
|
REFERENCE
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N/R
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N/R
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N/R
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N/R
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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
N/R |
N/R
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N/R
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N/R
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ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
inhalation | rat
lethal concentration (50 percent kill): >333 mg/m3/1 hour
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Behavioral: Somnolence (general depressed activity)
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ATDAEI 1,42,1990
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intravenous | mouse
lethal dose (50 percent kill): 180 mg/kg
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N/R
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CSLNX* NX#00905
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oral | rat
lethal dose (50 percent kill): 590 mg/kg
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Eye: Lacrimation | Behavioral: Somnolence (general depressed activity) Gastrointestinal: Changes in structure or function of salivary glands
ATDAEI 1,42,1990
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skin | rabbit
lethal dose (50 percent kill): 8,600 mg/kg
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Behavioral: Somnolence (general depressed activity)
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ATDAEI 1,42,1990
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
|
oral | rat
lowest published toxic dose: 5,443 mg/kg/28 day- continuous
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Behavioral: Altered sleep time (including change in righting reflex) | Behavioral: Convulsions or effect on seizure threshold Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
NTIS** OTS0573745
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REVIEWS:
ORGANIZATION
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STANDARD
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REFERENCE
N/R
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N/R
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N/R
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STANDARDS AND REGULATIONS:
ORGANIZATION
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STANDARD
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REFERENCE
N/R
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N/R
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N/R
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NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
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STANDARD or SURVEY
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REFERENCE
National Occupational Hazard Survey 1974
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National Occupational Hazard Survey 1974: Hazard Code: 83485; | Number of Industries 1; Total Number of Facilities 21; Number of Occupations 6; Total Number of Employees Exposed 171
National Occupational Exposure Survey 1983
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National Occupational Exposure Survey 1983: Hazard Code: 83485 |
Number of Industries 2; Total Number of Facilities 81; Number of Occupations 2; Total Number of Employees Exposed 648; Total Number of Female Employees Exposed 345 | ||||
STATUS IN FEDERAL AGENCIES:
ORGANIZATION
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REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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REFERENCES:
CODEN
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REFERENCE
ATDAEI
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Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert,
Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990-
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CSLNX*
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U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange
Chemicals. (Aberdeen Proving Ground, MD 21010)
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NTIS**
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National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse
for Scientific & Technical Information.
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