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s - Triazine, hexahydro - 1,3,5 - trinitro -

RTECS #: XY9450000

CAS #: 121-82-4

UPDATE: May 2009 MW: 222.15 MF: C3H6N6O6


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1,3,5 - Triazine, hexahydro - 1,3,5 - trinitro - (9CI)
  2. 1,3,5 - Trinitro - 1,3,5 - triazacyclohexane
  3. 1,3,5 - Trinitrohexahydro - s - triazine
  4. CX 84A
  5. Cyclonite
  6. Cyclonite (ACGIH:OSHA)
  7. Cyclotrimethylenenitramine
  8. Cyclotrimethylenetrinitramine
  9. Cyklonit (Czech)
  10. Esaidro - 1,3,5 - trinitro - 1,3,5 - triazina (Italian)
  11. Heksogen (Polish)
  12. Hexahydro - 1,3,5 - trinitro - 1,3,5 - triazin (German)
  13. Hexahydro - 1,3,5 - trinitro - 1,3,5 - triazine
  14. Hexahydro - 1,3,5 - trinitro - s - triazine
  15. Hexogeen (Dutch)
  1. Hexogen
  2. Hexogen (Explosive)
  3. Hexogen 5W
  4. Hexolite
  5. KHP 281
  6. PBXW 108 (E)
  7. PE 4
  8. Pbx (AF) 108
  9. RDX
  10. RDX (OSHA)
  11. Trimethyleentrinitramine (Dutch)
  12. Trimethylenetrinitramine
  13. Trinitrocyclotrimethylene triamine
  14. sym - Trimethylenetrinitramine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 88.9 µg/plate/73 hour (+enzymatic activation step) MUREAV 629,64,2007


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 10 gm/kg (13 week male/13 week prior to copulation-22 day pregnant) Reproductive: Effects on newborn: Stillbirth

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) 		NTIS** AD-A092-531
oral
rat 		lowest published toxic dose: 3 gm/kg (13 week male/13 week prior to copulation-22 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS** AD-A092-531
oral
rat 		lowest published toxic dose: 20 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) NTIS** AD-A166-249


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published lethal dose: 10 mg/kg N/R EATR** EB-TR-73040
intravenous
guinea pig 		lethal dose (50 percent kill): 25 mg/kg N/R EATR** EB-TR-73040
intravenous
mouse 		lethal dose (50 percent kill): 19 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea 		EATR** EB-TR-73040
intravenous
rat 		lowest published lethal dose: 18 mg/kg N/R EATR** EB-TR-73040
oral
cat 		lowest published lethal dose: 100 mg/kg N/R FATOAO 7,43,1944
oral
child 		lowest published toxic dose: 85 mg/kg Behavioral: Convulsions or effect on seizure threshold JTCTDW 24,305,1986
oral
mouse 		lethal dose (50 percent kill): 59 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea 		NTIS** AD-A092-531
oral
pig 		lowest published toxic dose: 43 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Nausea or vomiting 		TOXID9 44,254,2005
oral
pig 		lowest published toxic dose: 43 mg/kg Gastrointestinal: Nausea or vomiting TOXID9 44,254,2005
oral
quail 		lowest published lethal dose: 187 mg/kg N/R TOXID9 60,230,2001
oral
rat 		lethal dose (50 percent kill): 100 mg/kg Behavioral: Convulsions or effect on seizure threshold TXAPA9 39,531,1977
oral
rabbit 		lowest published lethal dose: 500 mg/kg N/R FATOAO 7,43,1944


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
dog 		lowest published toxic dose: 1,800 mg/kg/6 week- intermittent Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		JIHTAB 31,21,1949
oral
mouse 		lowest published toxic dose: 28,800 mg/kg/90 day- continuous Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTIS** AD-A092-531
oral
rat 		lowest published toxic dose: 3,600 mg/kg/90 day- continuous Cardiac: Other changes

Blood: Pigmented or nucleated red blood cells

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		NTIS** AD-A092-531
oral
rat 		lowest published toxic dose: 720 mg/kg/90 day- intermittent Behavioral: Tremor

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TOXID9 90,332,2006


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 mg/m3 (skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1.5 mg/m3 (skin) DTLVS* 3,221,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 1.5 mg/m3 (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 1.5 mg/m3 (skin) CFRGBR 29,1915.1000,1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 1.5 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 1.5 mg/m3, Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 1.5 mg/m3, OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 1.5 mg/m3, short term exposure limit 4.5 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 1.5 mg/m3, Skin, FEB2006
Occupational Exposure Limit - KOREA time-weighted average 1.5 mg/m3, short term exposure limit 3 mg/m3, skin, 2006
Occupational Exposure Limit - MEXICO time-weighted average 1.5 mg/m3 (skin), 2004
Occupational Exposure Limit - NEW ZEALAND time-weighted average 1.5 mg/m3, skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 1.5 mg/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.4 mg/m3, Skin, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 1 mg/m3, MAC(short term exposure limit) 3 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 1.5 mg/m3, Skin, DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CYCLONITE-air 10 hour time-weighted average 1.5 mg/m3;
short term exposure limit 3 mg/m3 (Sk) 		NIOSH* DHHS #95-121,1995
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M0317;
Number of Industries 1;
Total Number of Facilities 20;
Number of Occupations 2;
Total Number of Employees Exposed 242
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0317;
Number of Industries 3;
Total Number of Facilities 36;
Number of Occupations 4;
Total Number of Employees Exposed 488


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/264255)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a high explosive
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EATR** U.S. Army, Edgewood Arsenal Technical Report. (Aberdeen Proving Ground, MD 21010)
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as a high explosive

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Human Data

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