CDC logo, Safer Healthier People CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us




s - Triazine, 2 - ethylamino - 4 - isopropylamino - 6 - methylthio -

RTECS #: XY9100000

CAS #: 834-12-8

UPDATE: February 2009 MW: 227.37 MF: C9H17N5S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 2 - Ethylamino - 4 - isopropylamino - 6 - methylmercapto - s - triazine
  2. 2 - Ethylamino - 4 - isopropylamino - 6 - methylthio - s - triazine
  3. 2 - Ethylamino - 4 - isopropylamino - 6 - methylthio - 1,3,5 - triazine
  4. 2 - Methylthio - 4 - ethylamino - 6 - isopropylamino - S - triazine
  5. 2 - Methylmercapto - 4 - ethylamino - 6 - isopropylamino - S - triazine
  6. 2 - Methylmercapto - 4 - isopropylamino - 6 - ethylamino - S - triazine
  7. A 1093
  8. Ametrex
  9. Ametryn
  1. Ametryne
  2. Cemerin
  3. Crisatrine
  4. Evik
  5. G - 34162
  6. Gesapax
  7. N - Ethyl - N' - isopropyl - 6 - methylthio - 1,3,5 - triazine - 2,4 - diyldiamine
  8. Primatol Z 80
  9. Trinatox D


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		76 mg mild CIGET* -,-,1977


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 4,040 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		BECTA6 58,184,1997
oral
rat 		lowest published toxic dose: 2,500 mg/kg (6-15 day pregnant) Reproductive: Other effects on female

Reproductive: Other effects to embryo or fetus 		NNGADV 18,S213,1993
oral
rat 		lowest published toxic dose: 336,600 µg/kg (5-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other effects to embryo or fetus 		PCBPBS 53,1,1995
oral
rabbit 		lowest published toxic dose: 780 mg/kg (7-19 day pregnant) Reproductive: Other effects on female NNGADV 18,S213,1993


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): >2,200 mg/m3/4 hour N/R FMCHA2 -,C19,1991
oral
mouse 		lethal dose (50 percent kill): 965 mg/kg N/R PCOC** -,29,1966
oral
rat 		lethal dose (50 percent kill): 508 mg/kg N/R FAATDF 7,299,1986
skin
rat 		lethal dose (50 percent kill): >3 gm/kg N/R FAATDF 7,299,1986
skin
rabbit 		lethal dose (50 percent kill): 8,160 mg/kg N/R 85DPAN -,-,1971/1976


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
dog 		lowest published toxic dose: 18,200 mg/kg/52 week- continuous Behavioral: Food intake (animal)

Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NNGADV 18,S213,1993
oral
dog 		lowest published toxic dose: 18.2 gm/kg/52 week- intermittent Liver: Multiple effects HBPTO* 2,1512,2001
oral
mouse 		lowest published toxic dose: 27.37 gm/kg/78 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain HBPTO* 2,1514,2001
oral
rat 		lowest published toxic dose: 21,840 mg/kg/2 year- continuous Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NNGADV 18,S213,1993
oral
rat 		lowest published toxic dose: 7,740 mg/kg/90 day- intermittent Liver: Multiple effects HBPTO* 2,1512,2001
oral
rat 		lowest published toxic dose: 18.25 gm/kg/2 year- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain HBPTO* 2,1514,2001
oral
rat 		lowest published toxic dose: 18.25 gm/kg/2 year- continuous Blood: Other changes HBPTO* 2,1514,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
MUTAEX 21,93,2006
TOXICOLOGY REVIEW
FEREAC 73,31788,2008
TOXICOLOGY REVIEW
FEREAC 73,31788,2008


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,159,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X2457;
Number of Industries 1;
Total Number of Facilities 13;
Number of Occupations 9;
Total Number of Employees Exposed 567;
Total Number of Female Employees Exposed 13


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion
Used as a herbicide for selective weed control in sugarcane and pineapple
On EPA IRIS database


REFERENCES:

CODEN
REFERENCE
85DPAN "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
CIGET* Ciba-Geigy Toxicology Data/Indexes. (Ciba-Geigy Corp., 556 Morris Ave., Summit, NJ 07901)
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976-
PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1971-
PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS)
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998

Used as a herbicide for selective weed control in sugarcane and pineapple

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Primary Irritant

 Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us