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s - Triazine, 2 - (tert - butylamino) - 4 - (ethylamino) - 6 - (methylthio) -

RTECS #: XY4725000

CAS #: 886-50-0

UPDATE: May 2009 MW: 241.40 MF: C10H19N5S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1,3,5 - Triazine - 2,4 - diamine, N - (1,1 - dimethylethyl) - N' - ethyl - 6 - (methylthio) - (9CI)
  2. 2 - Methylthio - 4 - ethylamino - 6 - tert - butylamino - s - triazine
  3. 2 - tert - Butylamino - 4 - ethylamino - 6 - methylmercapto - s - triazine
  4. 2 - tert - Butylamino - 4 - ethylamino - 6 - methylthio - s - triazine
  5. 2 - tert.Butylamino - 4 - aethylamino - 6 - methylthio - 1,3,5 - triazin (German)
  6. 4 - Aethylamino - 2 - tert - butylamino - 6 - methylthio - s - triazin (German)
  7. A 1866
  8. Clarosan
  9. GS 14260
  10. HS - 14260
  1. Igran
  2. Igran 50
  3. Igran 500
  4. Prebane
  5. Saterb
  6. Short - stop E
  7. Shortstop
  8. Terbutrex
  9. Terbutryn
  10. Terbutryne


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		76 mg moderate CIGET* -,-,1977
skin
rabbit 		380 mg open irritation test mild CIGET* -,-,1977


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 109.5 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Reproductive: Other reproductive system tumors

Liver: Tumors 		HBPTO* 2,1514,2001


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): >8 gm/m3/4 hour N/R 85JFAN A384,1983
intraperitoneal
mouse 		lethal dose (50 percent kill): 554 mg/kg N/R PESTD5 17,351,1976
intraperitoneal
rat 		lethal dose (50 percent kill): 699 mg/kg N/R PESTD5 17,351,1976
oral
chicken 		lethal dose (50 percent kill): 4 gm/kg N/R 85JFAN A384,1983
oral
mouse 		lethal dose (50 percent kill): 3,884 mg/kg N/R PESTD5 17,351,1976
oral
rat 		lethal dose (50 percent kill): 2,045 mg/kg N/R PESTD5 17,351,1976
skin
rat 		lethal dose (50 percent kill): >2 gm/kg N/R PEMNDP 9,799,1991
skin
rabbit 		lethal dose (50 percent kill): >10,200 mg/kg N/R CIGET* -,-,1977
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 2,900 mg/kg N/R 30ZDA9 -,438,1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
dog 		lowest published toxic dose: 4,550 mg/kg/26 week- intermittent Gastrointestinal: Other changes HBPTO* 2,1512,2001
oral
rat 		lowest published toxic dose: 12.6 gm/kg/90 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain HBPTO* 2,1512,2001
oral
rat 		lowest published toxic dose: 10.95 gm/kg/2 year- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain HBPTO* 2,1514,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
HTOPA* 1,501,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,153,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X2462;
Number of Industries 1;
Total Number of Facilities 13;
Number of Occupations 9;
Total Number of Employees Exposed 567;
Total Number of Female Employees Exposed 13


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9249
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86
CIGET* Ciba-Geigy Toxicology Data/Indexes. (Ciba-Geigy Corp., 556 Morris Ave., Summit, NJ 07901)
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
HTOPA*
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
PESTD5 Proceedings of the European Society of Toxicology. (Amsterdam, Netherlands) V.16-18, 1975-77. Discontinued.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998

Used as a herbicide for selective weed control in wheat

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Primary Irritant

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