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s - Triazine, 2,4 - bis (isopropylamino) - 6 - (methylthio) -

RTECS #: XY4390000

CAS #: 7287-19-6

UPDATE: February 2006 MW: 241.40 MF: C10H19N5S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1,3,5 - Triazine - 2,4 - diamine, N,N' - bis (1 - methylethyl) - 6 - (methylthio) - (9CI)
  2. 2,4 - Bis (isopropylamino) - 6 - methyl mercapto - s - triazine
  3. 2,4 - Bis (isopropylamino) - 6 - methylthio - s - triazine
  4. 2,4 - Bis (isopropylamino) - 6 - methylthio - 1,3,5 - triazine
  5. 2,4 - Bis (propylamino) - 6 - methylthio - 1,3,5 - triazin (German)
  6. 2 - Methylthio - 4,6 - bis (isopropylamino) - s - triazine
  7. 2 - Methylmercapto - 4,6 - bis (isopropylamino) - s - triazine
  8. Caparol
  9. G 34161
  10. Gesagard
  11. Mercazin
  12. Merkazin
  13. N,N' - Bis (1 - methylethyl) - 6 - methyl - thio - 1,3,5 - triazine - 2,4 - diamine
  14. N,N' - Diisopropyl - 6 - methylthio - 1,3,5 - triazine - 2,4 - diyldiamine
  1. Polisin
  2. Primatol Q
  3. Promepin
  4. Promethryn
  5. Prometrene
  6. Prometrex
  7. Prometrin
  8. Prometryn
  9. Prometryne
  10. Selectin
  11. Selektin
  12. Sesagard
  13. Uvon
  14. s - Triazine, 4,6 - bis (isopropylamino) - 2 - methylmercapto -


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		80 mg mild CIGET* -,-,1977


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
gene conversion and mitotic recombination Saccharomyes cerevisiae 500 µg/L CYGEDX 21(2),59,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 2,400 mg/kg (18-20 day pregnant/2-4 day after birth) Reproductive: Effects on newborn: Behavioral

Reproductive: Effects on newborn: Physical

Reproductive: Effects on newborn: Delayed effects 		ZHYGAM 34,116,1988


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): >2,430 mg/m3/4 hour N/R 85JFAN A340,1983
oral
mouse 		lethal dose (50 percent kill): 2,138 mg/kg Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Respiratory depression

Kidney, Ureter, and Bladder: Urine volume increased 		GISAAA 33(2),12,1968
oral
rat 		lethal dose (50 percent kill): 2,100 mg/kg Autonomic Nervous System: Other (direct) parasympathomimetic

Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Other changes 		GISAAA 34(3),94,1969
oral
rat 		lethal dose (50 percent kill): 1,802 mg/kg N/R FEREAC 63,9494,1998
skin
rat 		lethal dose (50 percent kill): >3,100 mg/kg N/R PEMNDP 9,711,1991
skin
rabbit 		lethal dose (50 percent kill): >3,100 mg/kg N/R FMCHA2 -,C250,1991
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 1,800 mg/kg N/R GISAAA 44(6),81,1979


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
dog 		lowest published toxic dose: 27.3 gm/kg/104 week- intermittent Liver: Multiple effects

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in bone marrow not included in above 		HBPTO* 2,1512,2001
oral
mouse 		lowest published toxic dose: 78.29 gm/kg/78 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain HBPTO* 2,1514,2001
oral
rat 		lowest published toxic dose: 14,223 mg/kg/7 week- intermittent Liver: Changes in liver weight

Endocrine: Changes in adrenal weight

Blood: Other changes 		GISAAA 33(2),12,1968
oral
rat 		lowest published toxic dose: 45 gm/kg/90 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field HBPTO* 2,1512,2001
oral
rat 		lowest published toxic dose: 27.01 gm/kg/2 year- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain HBPTO* 2,1514,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,144,1998
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M3180;
Number of Industries 1;
Total Number of Facilities 167;
Number of Occupations 1;
Total Number of Employees Exposed 1,169
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M3180;
Number of Industries 1;
Total Number of Facilities 13;
Number of Occupations 9;
Total Number of Employees Exposed 567;
Total Number of Female Employees Exposed 13


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86
CIGET* Ciba-Geigy Toxicology Data/Indexes. (Ciba-Geigy Corp., 556 Morris Ave., Summit, NJ 07901)
CYGEDX Cytology and Genetics (English Translation). Translation of TGANAK. (Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.8- 1974-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1955-

Used as a herbicide for selective weed control in cotton and celery

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Primary Irritant

ALT CAS #: 83653-07-0
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